circRNA在非酒精性脂肪性肝病诊治中的应用价值

杜晟楠; 高静静; 汪涛; 蒋元烨; 曹勤

doi:10.3969/j.issn.1001-5256.2021.11.043

circRNA在非酒精性脂肪性肝病诊治中的应用价值

DOI: 10.3969/j.issn.1001-5256.2021.11.043

上海中医药大学附属普陀医院消化内科，上海 200062

基金项目:

国家自然科学基金青年项目 (81703879);

上海市卫计委临床研究专项面上项目 (201840377);

上海市卫计委临床研究专项面上项目 (201940449);

普陀区科委自主创新项目 (ptkwws201813);

上海中医药大学后备卓越中医人才项目 (20D-RC-02)

详细信息

通信作者:
蒋元烨，yuanye1014@126.com

曹勤，caoqin434@sina.com

中图分类号: R575.5
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- 文章访问数: 649
- HTML全文浏览量: 131
- PDF下载量: 55
- 被引次数: 0
出版历程
- 收稿日期: 2021-03-30
- 录用日期: 2021-04-28
- 出版日期: 2021-11-20

Value of circular RNA in the diagnosis and treatment of nonalcoholic fatty liver disease

Department of Gastroenterology, Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China

Research funding:

National Natural Science Foundation of China (81703879);

Shanghai Municipal Commission of Health and Family Planning General Project for Clinical Research of Health Industry (201840377);

Shanghai Municipal Commission of Health and Family Planning General Project for Clinical Research of Health Industry (201940449);

Putuo District of Shanghai Science And Technology Commission Research Project (ptkwws201813);

Reserve excellent TCM talents project of Shanghai University of traditional Chinese Medicine (20D-RC-02)

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)的患病率逐年增加, 目前已成为世界范围内最为常见的慢性肝病之一。研究发现, 环状RNA(circRNA)与NAFLD关系密切，被认为是NAFLD潜在的诊断生物标志物和治疗靶点。归纳了circRNA在NAFLD发病机制中的调控作用及其在诊断和治疗中的价值，指出cirRNA在NAFLD的发生发展进程中扮演着重要角色，并可能在NAFLD的诊断及治疗中具有重要临床意义。
- 非酒精性脂肪性肝病 /
- 环状RNA /
- 诊断 /
- 治疗学
Abstract: The prevalence rate of nonalcoholic fatty liver disease (NAFLD) is increasing year by year and it has become one of the most common chronic liver diseases in the world. Studies have shown that circular RNA (circRNA) is closely associated with NAFLD and is considered a potential diagnostic biomarker and therapeutic target for NAFLD. This article summarizes the regulatory role of circRNA in the pathogenesis of NAFLD and its value in diagnosis and treatment and points out that circRNA plays an important role in the development and progression of NAFLD and may have important clinical significance in the diagnosis and treatment of NAFLD.
- Non-alcoholic Fatty Liver Disease /
- Circular RNA /
- Diagnosis /
- Therapeutics

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参考文献(50)

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