细胞自噬在自身免疫性肝炎发生发展中的作用机制

杨培伟; 刘光伟; 赵文霞

doi:10.3969/j.issn.1001-5256.2021.11.044

细胞自噬在自身免疫性肝炎发生发展中的作用机制

DOI: 10.3969/j.issn.1001-5256.2021.11.044

河南中医药大学第一附属医院脾胃肝胆科，郑州 450000

基金项目:

国家自然科学基金 (82003994);

河南省中医药科学研究专项课题 (2019JDZX2034)

详细信息

通信作者:
杨培伟，397241708@qq.com

中图分类号: R575.1
计量
- 文章访问数: 440
- HTML全文浏览量: 85
- PDF下载量: 31
- 被引次数: 0
出版历程
- 收稿日期: 2021-03-01
- 录用日期: 2021-03-26
- 出版日期: 2021-11-20

Mechanism of autophagy in the development and progression of autoimmune hepatitis

Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China

Research funding:

National Natural Science Foundation of China (82003994);

Henan Province Traditional Chinese Medicine Research Project (2019JDZX2034)

摘要

摘要: 细胞自噬是机体细胞组织的自我防御和自我修复的过程，在调节机体的免疫炎症反应和维持肝细胞内环境平衡中发挥重要作用。从自噬调节免疫炎症反应、自噬调节免疫信号传导和防止过度激活的先天免疫反应方面，总结自噬在自身免疫性肝炎(AIH)发生发展中的作用机制。认为从细胞自噬角度可能揭示AIH的作用机制，为AIH的研究提供新思路和新方法。
- 肝炎, 自身免疫性 /
- 自噬 /
- 免疫, 先天
Abstract: Autophagy is a process of self-defense and self-repair of cells and tissues and plays an important role in regulating the body's immune inflammatory response and maintaining the homeostasis of liver cells. This article summarizes the mechanism of autophagy in the development and progression of autoimmune hepatitis (AIH) from the aspects of the role of autophagy in regulating immune inflammatory response, regulating immune signal transduction, and preventing overactivated innate immune response. It is believed that autophagy may reveal the mechanism of AIH and provide new ideas and methods for the research on AIH.
- Hepatitis, Autoimmune /
- Autophagy /
- Immunity, Innate

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