甲胎蛋白在肝衰竭患者预后判断中的作用

吴红; 李浩; 汤善宏

doi:10.3969/j.issn.1001-5256.2021.11.048

甲胎蛋白在肝衰竭患者预后判断中的作用

DOI: 10.3969/j.issn.1001-5256.2021.11.048

吴红^{1, 2},
李浩²,
汤善宏^2, ,

1.
成都中医药大学医学与生命科学学院，成都 610083
2.
西部战区总医院消化内科，成都 610083

基金项目:

四川省卫生健康委员会科研课题 (20PJ180)

详细信息

通信作者:
汤善宏，shanhongtang@163.com

中图分类号: R575.3
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- 文章访问数: 890
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- 被引次数: 0
出版历程
- 收稿日期: 2021-03-31
- 录用日期: 2021-04-20
- 出版日期: 2021-11-20

Role of alpha-fetoprotein in prognostic evaluation of patients with liver failure

Hong WU^{1, 2},
Hao LI²,
Shanhong TANG^{2
, ,}

1.
School of Medicine and Life Science, Chengdu University of Traditional Chinese Medicine, Chengdu 610083, China
2.
Department of Gastroenterology, The General Hospital of Western Theater Command, Chengdu 610083, China

Research funding:

Research Project of Sichuan Provincial Health Commission (20PJ180)

摘要

摘要: 我国是肝病大国，各种肝炎病毒、药物毒物及酒精等都会造成肝损伤，甚至肝衰竭。肝衰竭患者预后的关键在于肝自我修复及再生。甲胎蛋白(AFP)作为肿瘤标志物已在肝癌中得到深入研究，但其在肝衰竭患者肝再生中的研究尚有待深入。总结了AFP在肝再生中的基础研究以及在急性肝衰竭(ALF)和慢加急性肝衰竭(ACLF)中的临床研究，并归纳了本课题组前期研究结果——AFP是HBV相关ACLF后肝再生的重要预后指标及再生因子。经分析表明，继续深入研究AFP在各种肝衰竭中的预后作用以及肝再生中的发生机制，有助于进一步加深对AFP和肝再生的了解，为各种肝衰竭患者的临床诊治和预后评价提供新思路及方法。
- 肝功能衰竭 /
- 甲胎蛋白类 /
- 肝再生
Abstract: China is a big country with liver diseases, and various hepatitis viruses, drug poisons, and alcohol can cause liver injury and even liver failure. The key to the prognosis of patients with liver failure is liver self-repair and regeneration. Alpha-fetoprotein (AFP) has been extensively studied as a tumor marker in liver cancer, but its role in liver regeneration in patients with liver failure awaits further studies. This article summarizes the basic research on AFP in liver regeneration and the clinical research on AFP in acute liver failure and acute-on-chronic liver failure (ACLF), as well as the previous research findings of our group that AFP is an important prognostic index and regeneration factor for liver regeneration after hepatitis B virus-related ACLF. The analysis shows that further studies on the role of AFP in the prognosis of various types of liver failure and the mechanism of liver regeneration will help deepen our understanding of AFP and liver regeneration, thereby providing new ideas and methods for the clinical diagnosis, treatment, and prognostic evaluation of patients with various types of liver failure.
- Liver Failure /
- alpha-Fetoproteins /
- Liver Regeneration

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