Y-box结合蛋白1在慢性肝病发生发展中的作用

刘婷; 谢肖立; 姜慧卿

doi:10.3969/j.issn.1001-5256.2021.11.050

Y-box结合蛋白1在慢性肝病发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2021.11.050

河北医科大学第二医院消化内科，河北省消化病实验室，河北省消化病研究所，石家庄 050000

基金项目:

国家自然科学基金面上项目 (81770601);

河北省研究生创新资助项目 (CXZZBS2019121)

详细信息

通信作者:
姜慧卿，jianghq@aliyun.com

中图分类号: R575.2;R735.7
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- 文章访问数: 467
- HTML全文浏览量: 147
- PDF下载量: 23
- 被引次数: 0
出版历程
- 收稿日期: 2021-04-02
- 录用日期: 2021-04-22
- 出版日期: 2021-11-20

Role of Y-box binding protein-1 in the development and progression of chronic liver diseases

Department of Gastroenterology, The Second Hospital of Hebei Medical University; Hebei Key Laboratory of Gastroenterology; Hebei Institute of Gastroenterology, Shijiazhuang 050000, China

Research funding:

National Natural Science Foundation of China (81770601);

Post-graduate's Innovation Fund Project of Hebei Province (CXZZBS2019121)

摘要

摘要: 慢性肝病的病因多种多样，临床长期预后较差。Y-box结合蛋白1系一种多功能蛋白，近年来随着对其研究的深入，发现其在肝纤维化、肝细胞癌等慢性肝脏疾病的发生、发展等过程中均发挥着关键作用。总结了Y-box结合蛋白1在肝纤维化、肝细胞癌(增殖、凋亡、转移、疾病预后和耐药)及肝功能衰竭等慢性肝病中发挥的作用，为慢性肝病的诊治提供一定的理论依据。
- Y盒结合蛋白质1 /
- 肝硬化 /
- 肝细胞癌 /
- 肝功能衰竭
Abstract: Chronic liver diseases have various etiologies and often have poor long-term prognosis in clinical practice. Y-box binding protein-1 (YB-1) is a multifunctional protein, and in-depth studies in recent studies have found that it plays a key role in the development and progression of chronic liver diseases such as liver fibrosis and hepatocellular carcinoma (HCC). This article summarizes the role of YB-1 in chronic liver diseases such as liver fibrosis, HCC (proliferation, apoptosis, metastasis, prognosis, and drug resistance), and liver failure, so as to provide a theoretical basis for the diagnosis and treatment of chronic liver diseases.
- Y-Box-Binding Protein 1 /
- Liver Cirrhosis /
- Carcinoma, Hepatocellular /
- Liver Failure

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图 1 YB-1结构域示意图

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