肝内胆管改变与肝纤维化的关系
DOI: 10.3969/j.issn.1001-5256.2022.01.032
利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:尤文铮负责撰写修改论文; 任万雷负责参与文献的收集、整理; 宣世英、胡豆豆负责拟定写作思路,指导撰写文章并最后定稿。
Association between intrahepatic bile duct alterations and liver fibrosis
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摘要: 肝硬化是由多种原因引起的以弥漫性纤维组织增生、肝小叶结构破坏、假小叶形成为特征的肝病。在多种肝硬化动物模型及不同病因肝硬化患者中均可见胆管增生。多种神经肽、神经递质及激素等调节因子参与的信号通路调控胆管增生。增生的胆管通过介导星状细胞增殖、活化,促进肝纤维化的形成。总结了肝硬化时肝内胆管系统的改变及其对纤维化进程的影响,胆管细胞增生与肝纤维化相关的信号通路,以及胆管结构的动态演变对肝纤维化程度的预测价值。提出胆管增生可能成为干预肝纤维化的潜在靶点,为早期治疗及逆转肝纤维化提供新的思路和方法。Abstract: Liver cirrhosis is a liver disease caused by various factors and is characterized by diffuse fibrous hyperplasia, lobular structural damage, and pseudolobule formation. Bile duct proliferation has been observed in a variety of animal models of liver cirrhosis and patients with liver cirrhosis caused by different etiologies, and it is regulated by signaling pathways with the involvement of multiple regulatory factors such as neuropeptides, neurotransmitters, and hormones. Moreover, the proliferated bile ducts promote the formation of liver fibrosis by mediating the proliferation and activation of hepatic stellate cells. This article summarizes the changes of the intrahepatic bile duct system in liver cirrhosis and its influence on the process of liver fibrosis, various signaling pathways associated with cholangiocyte proliferation and liver fibrosis, and the value of the dynamic evolution of bile duct structure in predicting the degree of liver fibrosis. It is pointed out that bile duct proliferation may become a potential target for the intervention of liver fibrosis, which provides new ideas and methods for early treatment and reversal of liver fibrosis.
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Key words:
- Liver Cirrhosis /
- Bile Ducts, Intrahepatic /
- Pathologic Processes
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