莱菔硫烷对肝损伤的保护作用及相关机制研究进展

马欣雨; 段婷婷; 徐敬娅; 赵佳鹤; 张春蕾; 李宝龙

doi:10.3969/j.issn.1001-5256.2022.01.036

莱菔硫烷对肝损伤的保护作用及相关机制研究进展

DOI: 10.3969/j.issn.1001-5256.2022.01.036

1.
黑龙江中医药大学药物安全性评价中心，哈尔滨 150040
2.
黑龙江中医药大学佳木斯学院，黑龙江佳木斯 154000

基金项目:

国家自然科学基金面上项目 (81573135);

黑龙江省教育厅科学技术研究项目 (12541763)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：李宝龙、马欣雨负责课题设计，资料分析，撰写论文，修改论文；赵佳鹤、徐敬娅、段婷婷参与收集资料；李宝龙、张春蕾负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
李宝龙，lbl73@163.com

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- 被引次数: 0
出版历程
- 收稿日期: 2021-06-19
- 录用日期: 2021-07-21
- 出版日期: 2022-01-20

Research advances in the protective effect of sulforaphane against liver injury and related mechanisms

1.
Center for Safety Evaluation of Drugs, Heilongjiang University of Chinese Medicine, Harbin 150040, China
2.
Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi, Heilongjiang 154000, China

Research funding:

General Project of National Natural Science Foundation of China (81573135);

Science and Technology Research Project of Heilongjiang Provincial Department of Education (12541763)

摘要

摘要: 莱菔硫烷广泛存在于十字花科植物，是一种具有多种生物活性的植物化学物。本文对近年来国内外莱菔硫烷治疗各种不同类型肝损伤的实验研究进行总结，对莱菔硫烷保护肝损伤的作用及相关机制进行综述。以实验动物肝损伤模型为基础，归纳了莱菔硫烷对化学性、药物性、酒精性、免疫性及缺血再灌注等肝损伤模型的治疗作用，分析了莱菔硫烷改善实验性肝损伤的作用机制，为莱菔硫烷在肝损伤保护方面的深入研究提供参考。
- 莱菔硫烷 /
- 肝损伤 /
- 病理过程
Abstract: Sulforaphane is a phytochemical with a variety of biological activities that exists widely in Cruciferae plants. This article summarizes the recent experimental studies of sulforaphane in the treatment of various types of liver injury in China and globally and reviews the role and mechanism of sulforaphane in protecting against liver injury. Based on the experimental animal models of liver injury, this article summarizes the therapeutic effect of sulforaphane on the models of chemical liver injury, drug-induced liver injury, alcoholic liver injury, immunological liver injury, and ischemia/reperfusion liver injury and analyzes the mechanism of action of sulforaphane in improving experimental liver injury, so as to provide a reference for in-depth research on sulforaphane in protecting against liver injury.
- Sulforaphane /
- Liver Injury /
- Pathologic Processes

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参考文献(33)

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