瞬时感受器电位离子通道蛋白V4在肝脏疾病中的作用机制

张腊英; 陈明锴

doi:10.3969/j.issn.1001-5256.2022.01.040

瞬时感受器电位离子通道蛋白V4在肝脏疾病中的作用机制

DOI: 10.3969/j.issn.1001-5256.2022.01.040

张腊英,
陈明锴^,

武汉大学人民医院消化内科，武汉 430060

基金项目:

湖北省重点研发项目 (2020BCB007)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：张腊英对研究的思路或设计有关键贡献；陈明锴负责修改论文中的关键性部分。

详细信息

通信作者:
陈明锴，kaimingchen@163.com

计量
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- 被引次数: 0
出版历程
- 收稿日期: 2021-05-30
- 录用日期: 2021-07-12
- 出版日期: 2022-01-20

Research advances in the mechanism of action of TRPV4 ion channel protein in liver diseases

Laying ZHANG,
Mingkai CHEN^,

Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China

Research funding:

The Key Project of Hubei Province (2020BCB007)

摘要

摘要: 瞬时感受器电位离子通道蛋白V4 (TRPV4)属于瞬时感受器电位离子通道家族中的一员，是一种非选择性阳离子通道，其广泛分布在多种组织及器官中。近年来越来越多的研究介绍了TRPV4通道蛋白与肝纤维化、肝癌、多囊性肝病等肝脏疾病的密切关系。本文主要对TRPV4与肝脏疾病的有关文献进行分析，归纳总结TRPV4与肝脏疾病之间确切的信号通路及可能的潜在机制，以期临床应用及进一步研究。
- 肝疾病 /
- 瞬变感受器电位离子通道蛋白V4 /
- 瞬时受体电位通道
Abstract: As a member of the transient receptor potential ion channel family, transient receptor potential vanilloid 4 (TRPV4) is a non-selective cation channel and is widely distributed in a variety of tissues and organs. In recent years, more and more studies have shown that TRPV4 channel proteins are closely associated with liver diseases such as liver fibrosis, liver cancer, and polycystic liver disease. This article analyzes the articles on TRPV4 and liver disease and summarizes the exact signaling pathways and possible potential mechanism between TRPV4 and liver disease, so as to provide new ideas for clinical application and further studies.
- Liver Diseases /
- Transient Receptor Potential Vanilloid 4 /
- Transient Receptor Potential Channels

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参考文献(48)

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