自发性细菌性腹膜炎的分子诊断研究进展

吴浩馨; 胡中杰

doi:10.3969/j.issn.1001-5256.2022.01.042

自发性细菌性腹膜炎的分子诊断研究进展

DOI: 10.3969/j.issn.1001-5256.2022.01.042

吴浩馨,
胡中杰^,

首都医科大学附属北京佑安医院肝病中心一科，北京 100069

基金项目:

北京市肝病研究所基金 (Y-2021YS-1)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：吴浩馨负责文献检索和论文撰写；胡中杰负责论文审校。

详细信息

通信作者:
胡中杰，huzhongjie@ccmu.edu.cn

计量
- 文章访问数: 522
- HTML全文浏览量: 120
- PDF下载量: 70
- 被引次数: 0
出版历程
- 收稿日期: 2021-06-05
- 录用日期: 2021-06-28
- 出版日期: 2022-01-20

Research advances in the molecular diagnosis of spontaneous bacterial peritonitis

Haoxin WU,
Zhongjie HU^,

First Department of Liver Disease Center, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China

Research funding:

Beijing Institute of Hepatology Foundation (Y-2021YS-1)

摘要

摘要: 自发性细菌性腹膜炎(SBP)是终末期肝病最常见的感染类型，SBP的诊断和治疗面临着很大的困难和挑战。近些年来，分子诊断技术尽管获得了极大的进步，但未广泛应用于临床实践。本文根据SBP的诊断现状，综述分子微生物诊断方法在SBP诊断上的进展，单纯细菌定性并不能明确细菌DNA与临床表现的关系，细菌定量结合其类型更能准确描述SBP的生物学特征，可为SBP及其特殊类型的诊断和指导抗菌药物的应用提供可能。
- 腹膜炎 /
- DNA, 细菌 /
- 诊断
Abstract: Spontaneous bacterial peritonitis (SBP) is the most common type of infection in end-stage liver disease, and the diagnosis and treatment of SBP are facing great difficulties and challenges. In recent years, great achievements have been made in molecular diagnostic techniques, but they have not been widely used in clinical practice. Based on the current status of the diagnosis of SBP, this article reviews the advances in molecular microbiological methods in the diagnosis of SBP. Bacterial qualitative analysis alone cannot clarify the association between bacterial DNA and clinical manifestations, and the combination of bacterial quantitative analysis and bacterial type can more accurately describe the biological characteristics of SBP, which may help with the diagnosis of SBP and its special types and the application of antimicrobial agents.
- Peritonitis /
- DNA, Bacterial /
- Diagnosis

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参考文献(28)

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