新生儿急性肝衰竭的病因、诊断及治疗

覃小梅; 李双杰

doi:10.3969/j.issn.1001-5256.2022.02.002

新生儿急性肝衰竭的病因、诊断及治疗

DOI: 10.3969/j.issn.1001-5256.2022.02.002

覃小梅,
李双杰^,

湖南省儿童医院肝病中心, 湖南省儿童肝病临床医学研究中心, 长沙 410007

基金项目:

国家自然科学基金 (81671969)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：覃小梅负责课题设计、资料分析、撰写论文、修改论文；李双杰负责拟定写作思路, 指导撰写文章并最后定稿。

详细信息

通信作者:
李双杰, 2273858951@qq.com

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出版历程
- 收稿日期: 2021-12-14
- 录用日期: 2022-01-14
- 出版日期: 2022-02-20

Etiology, diagnosis, and treatment of acute liver failure in neonates

Xiaomei QIN,
Shuangjie LI^,

Hunan Provincial Clinical Research Center for Childhood Liver Diseases, Department of Hepatopathy, Hunan Children's Hospital, Changsha 410007, China

Research funding:

National Natural Science Foundation of China (81671969)

More Information

Corresponding author: LI Shuangjie, 2273858951@qq.com

摘要

摘要: 新生儿急性肝衰竭是发生在新生儿期的急性肝功能完全或大部分丧失、危及生命的一种少见疾病, 出生后即可有肝硬化表现, 病死率高。主要病因包括妊娠期自身免疫性肝病、病毒感染、血液病、代谢性疾病和缺血性损伤及其他罕见原因等。治疗手段主要为对因治疗, 病因不明或既定治疗无反应患者, 肝移植仍然是其一项重要的治疗选择。目前新生儿急性肝衰竭相关研究较少, 因此需要对影响治疗和预后的因素进行前瞻性研究。
- 肝功能衰竭, 急性 /
- 诊断 /
- 治疗学
Abstract: Neonatal acute liver failure is a rare and life-threatening disease in the neonatal period with complete or substantial loss of liver function, and liver cirrhosis can be identified after birth, with a high mortality rate. The main etiologies of this disease include autoimmune liver diseases during pregnancy, viral infection, blood diseases, metabolic diseases, ischemic injury, and other rare causes. At present, etiological treatment is the main treatment method, and liver transplantation is still an important option for patients with unknown etiology or no response to established treatments. Currently there are few studies on neonatal acute liver failure, so prospective studies are needed to investigate the influencing factors for treatment and prognosis.
- Liver Failure, Acute /
- Diagnosis /
- Therapeutics

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参考文献(17)

[1]	CIOCCA M, ÁLVAREZ F. Neonatal acute liver failure: A diagnosis challenge[J]. Arch Argent Pediatr, 2017, 115(2): 175-180. DOI: 10.5546/aap.2017.eng.175.
[2]	KARADAǦ N, OKBAY GÜNEŞ A, KARATEKIN G. Acute liver failure in newborns[J]. Turk Arch Pediatr, 2021, 56(2): 108-114. DOI: 10.5152/TurkArchPediatr.2021.190205.
[3]	TAYLOR SA, WHITINGTON PF. Neonatal acute liver failure[J]. Liver Transpl, 2016, 22(5): 677-685. DOI: 10.1002/lt.24433.
[4]	SHANMUGAM NP, BANSAL S, GREENOUGH A, et al. Neonatal liver failure: Aetiologies and management-state of the art[J]. Eur J Pediatr, 2011, 170(5): 573-581. DOI: 10.1007/s00431-010-1309-1.
[5]	ZOZAYA NIETO C, FERNÁNDEZ CAAMAÑO B, MUÑOZ BARTOLO G, et al. Presenting features and prognosis of ischemic and nonischemic neonatal liver failure[J]. J Pediatr Gastroenterol Nutr, 2017, 64(5): 754-759. DOI: 10.1097/MPG.0000000000001501.
[6]	CASAS-ALBA D, CLOTET J, INAREJOS EJ, et al. Broadening the spectrum of neonatal hemochromatosis[J]. J Matern Fetal Neonatal Med, 2020, 33(6): 1024-1026. DOI: 10.1080/14767058.2018.1506442.
[7]	BERSANI I, AURITI C, PIERSIGILLI F, et al. Neonatal acute liver failure due to enteroviruses: A 14 years single NICU experience[J]. J Matern Fetal Neonatal Med, 2020, 33(15): 2576-2580. DOI: 10.1080/14767058.2018.1555806.
[8]	DEMIRBAS D, COELHO AI, RUBIO-GOZALBO ME, et al. Hereditary galactosemia[J]. Metabolism, 2018, 83: 188-196. DOI: 10.1016/j.metabol.2018.01.025.
[9]	LI H, BYERS HM, DIAZ-KUAN A, et al. Acute liver failure in neonates with undiagnosed hereditary fructose intolerance due to exposure from widely available infant formulas[J]. Mol Genet Metab, 2018, 123(4): 428-432. DOI: 10.1016/j.ymgme.2018.02.016.
[10]	AKTUGLU-ZEYBEK AC, KIYKIM E, CANSEVER MS. Hereditary tyrosinemia type 1 in Turkey[J]. Adv Exp Med Biol, 2017, 959: 157-172. DOI: 10.1007/978-3-319-55780-9_15.
[11]	KANUNGO S, MORTON J, NEELAKANTAN M, et al. Mitochondrial disorders[J]. Ann Transl Med, 2018, 6(24): 475. DOI: 10.21037/atm.2018.12.13.
[12]	MOREIRA-SILVA H, MAIO I, BANDEIRA A, et al. Metabolic liver diseases presenting with neonatal cholestasis: At the crossroad between old and new paradigms[J]. Eur J Pediatr, 2019, 178(4): 515-523. DOI: 10.1007/s00431-019-03328-5.
[13]	CAPPELL MS, HADER I, AMIN M. Acute liver failure secondary to severe systemic disease from fatal hemophagocytic lymphohistiocytosis: Case report and systematic literature review[J]. World J Hepatol, 2018, 10(9): 629-636. DOI: 10.4254/wjh.v10.i9.629.
[14]	HEISSAT S, COLLARDEAU-FRACHON S, BARUTEAU J, et al. Neonatal hemochromatosis: Diagnostic work-up based on a series of 56 cases of fetal death and neonatal liver failure[J]. J Pediatr, 2015, 166(1): 66-73. DOI: 10.1016/j.jpeds.2014.09.030.
[15]	FACCIORUSSO A, CHANDAR AK, MURAD MH, et al. Comparative efficacy of pharmacological strategies for management of type 1 hepatorenal syndrome: A systematic review and network meta-analysis[J]. Lancet Gastroenterol Hepatol, 2017, 2(2): 94-102. DOI: 10.1016/S2468-1253(16)30157-1.
[16]	ALOBAIDI R, ANTON N, CAVE D, et al. Predicting early outcomes of liver transplantation in young children: The EARLY study[J]. World J Hepatol, 2018, 10(1): 62-72. DOI: 10.4254/wjh.v10.i1.62.
[17]	SUNDARAM SS, ALONSO EM, ANAND R, et al. Outcomes after liver transplantation in young infants[J]. J Pediatr Gastroenterol Nutr, 2008, 47(4): 486-492. DOI: 10.1097/MPG.0b013e318175d7d2.