儿童急性肝衰竭的肝移植治疗
DOI: 10.3969/j.issn.1001-5256.2022.02.006
利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:王能里撰写文章;谢新宝拟定写作思路, 修改文章并最后定稿。
-
摘要: 儿童急性肝衰竭(PALF)是一种罕见的综合征, 致死率高。肝移植仍然是目前PALF唯一疗效肯定的治疗方法。近年来, 我国儿童肝移植技术日趋成熟, 已显著改善PALF预后。但PALF进行肝移植仍存在许多问题, 充分讨论PALF患儿行肝移植术术前、术中和术后存在的客观问题, 将进一步改善PALF患儿的整体预后。Abstract: Pediatric acute liver failure (PALF) is a rare syndrome with high mortality, and at present, liver transplantation is still the only effective treatment method for PALF. In recent years, the technology of liver transplantation in children has become more and more mature and has significantly improved the prognosis of PALF patients in China. However, there are still many problems in liver transplantation for PALF patients. Comprehensive discussion of objective problems before, during, and after liver transplantation may further improve the overall prognosis of PALF patients.
-
Key words:
- Liver Failure, Acute /
- Child /
- Liver Transplantation /
- Postoperative Complications
-
[1] JAIN V, DHAWAN A. Prognostic modeling in pediatric acute liver failure[J]. Liver Transpl, 2016, 22(10): 1418-1430. DOI: 10.1002/lt.24501. [2] SQUIRES RH Jr, SHNEIDER BL, BUCUVALAS J, et al. Acute liver failure in children: The first 348 patients in the pediatric acute liver failure study group[J]. J Pediatr, 2006, 148(5): 652-658. DOI: 10.1016/j.jpeds.2005.12.051. [3] Organ Transplantation Branch, Chinese Medical Doctor Association, Chinese Society of Organ Transplantation, Chinese Medical Association. Clinical guidelines for pediatric liver transplantation in China(2015)[J]. J Clin Hepatol, 2016, 32(7): 1235-1244. DOI: 10.3969/j.issn.1001-5256.2016.07.001.中华医学会器官移植学分会, 中国医师协会器官移植医师分会. 中国儿童肝移植临床诊疗指南(2015版)[J]. 临床肝胆病杂志, 2016, 32(7): 1235-1244. DOI: 10.3969/j.issn.1001-5256.2016.07.001. [4] LU BR, ZHANG S, NARKEWICZ MR, et al. Evaluation of the liver injury unit scoring system to predict survival in a multinational study of pediatric acute liver failure[J]. J Pediatr, 2013, 162(5): 1010-1016. e1-e4. DOI: 10.1016/j.jpeds.2012.11.021. [5] SUNDARAM V, SHNEIDER BL, DHAWAN A, et al. King's College Hospital Criteria for non-acetaminophen induced acute liver failure in an international cohort of children[J]. J Pediatr, 2013, 162(2): 319-323. e1. DOI: 10.1016/j.jpeds.2012.07.002. [6] DHAWAN A, TAYLOR RM, CHEESEMAN P, et al. Wilson's disease in children: 37-year experience and revised King's score for liver transplantation[J]. Liver Transpl, 2005, 11(4): 441-448. DOI: 10.1002/lt.20352. [7] KUMAR R, SHALIMAR, SHARMA H, et al. Prospective derivation and validation of early dynamic model for predicting outcome in patients with acute liver failure[J]. Gut, 2012, 61(7): 1068-1075. DOI: 10.1136/gutjnl-2011-301762. [8] YAMASHIKI N, SUGAWARA Y, TAMURA S, et al. Outcomes after living donor liver transplantation for acute liver failure in Japan: Results of a nationwide survey[J]. Liver Transpl, 2012, 18(9): 1069-1077. DOI: 10.1002/lt.23469. [9] UEMOTO S, INOMATA Y, SAKURAI T, et al. Living donor liver transplantation for fulminant hepatic failure[J]. Transplantation, 2000, 70(1): 152-157. https://www.ncbi.nlm.nih.gov/pubmed/10919593 [10] WEINER J, GRIESEMER A, ISLAND E, et al. Longterm outcomes of auxiliary partial orthotopic liver transplantation in preadolescent children with fulminant hepatic failure[J]. Liver Transpl, 2016, 22(4): 485-494. DOI: 10.1002/lt.24361. [11] RELA M, KALIAMOORTHY I, REDDY MS. Current status of auxiliary partial orthotopic liver transplantation for acute liver failure[J]. Liver Transpl, 2016, 22(9): 1265-1274. DOI: 10.1002/lt.24509. [12] DONG HM, DAI Y, ZHANG XX, et al. Meta analysis of therapeutic effects on patients with ABO-incompatibility liver transplantation[J]. Ogran Transplantation, 2016, 7(5): 370-377. DOI: 10.3969/j.issn.1674-7445.2016.05.008.董红锰, 代扬, 张欣雪, 等. ABO血型不合肝移植疗效的Meta分析[J]. 器官移植, 2016, 7(5): 370-377. DOI: 10.3969/j.issn.1674-7445.2016.05.008. [13] HONDA M, SUGAWARA Y, KADOHISA M, et al. Long-term outcomes of ABO-incompatible pediatric living donor liver transplantation[J]. Transplantation, 2018, 102(10): 1702-1709. DOI: 10.1097/TP.0000000000002197. [14] EGAWA H, OIKE F, BUHLER L, et al. Impact of recipient age on outcome of ABO-incompatible living-donor liver transplantation[J]. Transplantation, 2004, 77(3): 403-411. DOI: 10.1097/01.TP.0000110295.88926.5C. [15] QU W, ZHU ZJ. Research progress of ABO incompatible liver transplantation in children[J]. Chin J Organ Transplant, 2013, 34(8): 510-512. DOI: 10.3760/cma.j.issn.0254-1785.2013.08.018.曲伟, 朱志军. 儿童ABO血型不相容肝移植的研究进展[J]. 中华器官移植杂志, 2013, 34(8): 510-512. DOI: 10.3760/cma.j.issn.0254-1785.2013.08.018. [16] Branch of Organ Transplantation of Chinese Medical Association. Diagnosis and treatment specification for postoperative complications after liver transplantation in China (2019 edition)[J]. Ogran Transplantation, 2021, 12(2): 129-133. DOI: 10.3969/j.issn.1674-7445.2021.02.002.中华医学会器官移植学分会. 中国肝移植术后并发症诊疗规范(2019版)[J]. 器官移植, 2021, 12(2): 129-133. DOI: 10.3969/j.issn.1674-7445.2021.02.002. [17] Branch of Organ Transplantation of Chinese Medical Association. Diagnosis and treatment specification for immunosuppressive therapy and rejection of liver transplantation in China (2019 edition)[J]. Ogran Transplantation, 2021, 12(1): 8-14, 28. DOI: 10.3969/j.issn.1674-7445.2021.01.002.中华医学会器官移植学分会. 中国肝移植免疫抑制治疗与排斥反应诊疗规范(2019版)[J]. 器官移植, 2021, 12(1): 8-14, 28. DOI: 10.3969/j.issn.1674-7445.2021.01.002. [18] OISHI K, ARNON R, WASSERSTEIN MP, et al. Liver transplantation for pediatric inherited metabolic disorders: Considerations for indications, complications, and perioperative management[J]. Pediatr Transplant, 2016, 20(6): 756-769. DOI: 10.1111/petr.12741. [19] MAGGIORE G, GONZALES E, SCIVERES M, et al. Relapsing features of bile salt export pump deficiency after liver transplantation in two patients with progressive familial intrahepatic cholestasis type 2[J]. J Hepatol, 2010, 53(5): 981-986. DOI: 10.1016/j.jhep.2010.05.025.
本文二维码
计量
- 文章访问数: 656
- HTML全文浏览量: 165
- PDF下载量: 66
- 被引次数: 0