Wnt信号通路与肝纤维化的关系

范钦; 李红俊; 李晓霞; 杨尹; 陈海燕; 成家茂

doi:10.3969/j.issn.1001-5256.2022.02.038

Wnt信号通路与肝纤维化的关系

DOI: 10.3969/j.issn.1001-5256.2022.02.038

范钦¹,
李红俊²,
李晓霞²,
杨尹²,
陈海燕^2, ,,
成家茂^1, ,

1.
大理大学基础医学院解剖学教研室，云南大理 671000
2.
大理大学临床医学院超声教研室，云南省第四人民医院超声科，云南大理 671000

基金项目:

2021年云南省地方本科高校基础研究联合专项资金面上项目 (202101BA070001-101);

2022年云南省教育厅科学研究基金 (2022Y809);

2021年云南省教育厅科学研究基金 (2021J0382);

2017年度云南省自然科学基金高校联合基金 (2017FH001-076);

云南省李云庆专家工作站项目 (202005AF150014);

大理大学神经生物学创新团队项目 (ZKLX2019108)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：范钦、李红俊、李晓霞、杨尹负责查找文献，资料分析，撰写论文；成家茂、陈海燕负责拟定写作框架，指导思路并修改稿件和最后定稿。

详细信息

通信作者:
陈海燕, 316573230@qq.com

成家茂, chjmao@163.com

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- 被引次数: 0
出版历程
- 收稿日期: 2021-07-05
- 录用日期: 2021-08-11
- 出版日期: 2022-02-20

Association between the Wnt signaling pathway and hepatic fibrosis

Qin FAN¹,
Hongjun LI²,
Xiaoxia LI²,
Yin YANG²,
Haiyan CHEN^{2
, ,},
Jiamao CHENG^{1
, ,}

1.
Department of Human Anatomy, Basic Medical College of Dali University, Dali, Yunnan 671000, China
2.
Department of Ultrasound, School of Clinical Medicine, Dali University; Department of Ultrasound, The Fourth People's Hospital of Yunnan Province, Dali, Yunnan 671000, China

Research funding:

General Project of Special Joint Fund for the Basic Research of Local Undergraduate Colleges and Universities in Yunnan Province in 2021 (202101BA070001-101);

The 2022 Scientific Research Fund of the Education Department of Yunnan Province (2022Y809);

The 2021 Scientific Research Fund of the Education Department of Yunnan Province (2021J0382);

The 2017 Joint University Fund of Natural Science Foundation of Yunnan Province (2017FH001-076);

Project of Li Yunqing Expert Workstation of Yunnan Province (202005AF150014);

Innovation Team of Neurobiology of Dali University (ZKLX2019108)

More Information

Corresponding author: CHEN Haiyan, 316573230@qq.com; CHENG Jiamao, chjmao@163.com

摘要

摘要: 在各种慢性肝损伤后，肝纤维化是生物体的一种自我修复性病理过程，并能引起肝硬化、肝癌等疾病。Wnt信号通路广泛存在于无脊椎动物和脊椎动物中，是一类在物种进化过程中高度保守的信号通路。许多研究已经证实Wnt信号通路与肝纤维化的发生发展有密切联系。主要从经典和非经典Wnt信号通路调控肝星状细胞、肝巨噬细胞、肝祖细胞的机制方面进行概述，为后续深入开展Wnt信号调控肝纤维化机制研究及探索可逆转肝纤维化的治疗靶点提供新思路。
- 肝硬化 /
- Wnt信号通路 /
- 肝星状细胞 /
- 枯否细胞 /
- 干细胞
Abstract: Hepatic fibrosis (HF) is a self-healing pathological process after all kinds of chronic liver injuries and can cause diseases such as liver cirrhosis and liver cancer. The Wnt signaling pathway is highly conserved in species evolution and widely exists in invertebrates and vertebrates, and many studies have confirmed that the Wnt signaling pathway is closely associated with the development and progression of HF. This article reviews the mechanisms of the classical and non-classical Wnt signaling pathways in regulating hepatic stellate cells, hepatic macrophages, and hepatic progenitor cells, so as to provide new ideas for subsequent studies on the mechanism of the Wnt signaling pathway in regulating HF and further exploration of therapeutic targets that can reverse HF.
- Liver Cirrhosis /
- Wnt Signaling Pathway /
- Hepatic Stellate Cells /
- Kupffer Cells /
- Stem Cells

HTML全文

图 1 Wnt信号通路的经典途径和非经典途径^[3-4]

下载: 全尺寸图片幻灯片

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