肝脏驻留自然杀伤细胞在肝细胞癌发生发展中的作用

王俊旗; 徐锋

doi:10.3969/j.issn.1001-5256.2022.02.041

肝脏驻留自然杀伤细胞在肝细胞癌发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2022.02.041

王俊旗,
徐锋^,

中国医科大学附属盛京医院普通外科，沈阳 110004

基金项目:

辽宁省自然科学基金项目 (20180551193);

辽宁省自然科学基金项目 (2020-MS-181);

盛京医院345人才工程计划 (40B)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：王俊旗、徐锋负责课题设计，收集数据，资料分析，撰写论文并最后定稿。

详细信息

通信作者:
徐锋, xufengsjh@126.com

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- 被引次数: 0
出版历程
- 收稿日期: 2021-06-20
- 录用日期: 2021-07-21
- 出版日期: 2022-02-20

Role of liver-resident natural killer cells in the development and progression of hepatocellular carcinoma

Junqi WANG,
Feng XU^,

Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China

Research funding:

The Natural Science Fund of Liaoning Province (20180551193);

The Natural Science Fund of Liaoning Province (2020-MS-181);

The 345 Talent Project of Shengjing Hospital (40B)

More Information

Corresponding author: XU Feng, xufengsjh@126.com

摘要

摘要: 肝脏驻留自然杀伤(LrNK)细胞作为新近发现的组织驻留性自然杀伤细胞，具有较强的免疫杀伤功能。在肝细胞癌(HCC)的发生发展过程中，LrNK细胞功能受损，且可能通过上调相关免疫检查点的表达促进HCC进展。基于最新的相关研究，综述了LrNK细胞的免疫功能及其在HCC发生发展过程中的作用，以期探究该细胞在HCC免疫治疗中的应用前景。
- 癌, 肝细胞 /
- 杀伤细胞, 天然 /
- 免疫疗法
Abstract: Liver-resident natural killer (LrNK) cells, as a type of newly discovered tissue-resident natural killer cells, have a strong immune killing function. During the development and progression of hepatocellular carcinoma (HCC), the function of LrNK cells is impaired and such cells may promote the progression of HCC by upregulating the expression of related immune checkpoints. Based on the latest research, this article reviews the immune function of LrNK cells and their role in the development and progression of HCC, in order to explore the application prospect of these cells in HCC immunotherapy.
- Carcinoma, Hepatocellular /
- Killer Cells, Natural /
- Immunotherapy

HTML全文

图 1 LrNK细胞在不同肝脏状态下的功能改变

注：a，在正常肝脏中，LrNK细胞高表达NKp44、NKp46和NKG2D，低表达IFNγ^[13]；b，在病毒性肝炎中，LrNK细胞NKp46和NKG2D表达水平升高，但其TRAIL的表达以及脱颗粒能力减弱^[26-27]；c，在肝纤维化和肝硬化中，LrNK细胞NKp46、CD161的表达及穿孔素的分泌减少，且对HSC的杀伤活性受到抑制^[29-31]；d，在HCC中，LrNK细胞免疫检查点(TIM-3、LAG-3、TIGIT)表达上调，且抗肿瘤活性(NKG2D、TRAIL、FASL)受到抑制^[32-34]。

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