运动疗法对肝硬化伴肌少症的作用及其机制

廖粤生; 白莉莉

doi:10.3969/j.issn.1001-5256.2022.03.036

运动疗法对肝硬化伴肌少症的作用及其机制

DOI: 10.3969/j.issn.1001-5256.2022.03.036

廖粤生,
白莉莉^, ,

天津师范大学体育科学学院，天津 300387

基金项目:

国家社会科学基金重大项目 (19ZDA353);

国家社会科学基金青年项目 (20CTY004)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：廖粤生负责拟定写作思路，分析资料，撰写及修改论文；白莉莉负责指导撰写文章并最后定稿。

详细信息

通信作者:
白莉莉，blx0305@163.com

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出版历程
- 收稿日期: 2021-07-27
- 录用日期: 2021-09-16
- 出版日期: 2022-03-20

Role and mechanism of exercise in improving liver cirrhosis with sarcopenia

Yuesheng LIAO,
Lili BAI^{,
,}

School of Physical Sciences, Tianjin Normal University, Tianjin 300387, China

Research funding:

The National Social Science Fund of China (19ZDA353);

The National Social Science Fund of China (20CTY004)

More Information

Corresponding author: BAI Lili, blx0305@163.com(ORCID: 0000-0002-2216-8723)

摘要

摘要: 肌少症是肝硬化患者营养不良的重要表现，是肝硬化常见的并发症之一，30%~70%的肝硬化患者并发肌少症，严重影响生存和预后。运动疗法对于治疗此类疾病具有副作用少、效益高、操作性强等诸多优势。本文通过梳理国内外关于运动与肝硬化伴肌少症的相关理论研究和应用成果，循证运动对肝硬化伴肌少症的影响及相关机制，以期为治疗肝硬化伴肌少症提供科学的理论参考。
- 肝硬化 /
- 肌减少症 /
- 运动疗法
Abstract: Sarcopenia is an important manifestation of malnutrition in patients with liver cirrhosis and is one of the common complications of liver cirrhosis, and about 30%-70% of the patients with liver cirrhosis suffer from sarcopenia, which seriously affects the survival and prognosis of patients. Studies have shown that exercise therapy has many advantages in the treatment of such diseases, such as few side effects, high benefits, and simple operability. To summarize the theoretical studies and application results of exercise in liver cirrhosis with sarcopenia and find evidence for the effect of exercise on liver cirrhosis with sarcopenia and related mechanisms, in order to provide a scientific reference for the treatment of liver cirrhosis with sarcopenia.
- Liver Cirrhosis /
- Sarcopenia /
- Exercise Therapy

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图 1 运动改善肝硬化伴肌少症的可能机制

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表 1 有氧运动与抗阻运动对肝硬化伴肌少症患者的影响

研究对象	例数	运动类型	运动时间	研究结果	文献
肝硬化患者	92	有氧运动	2~3个月，2次/周	VO_{2 max}↑ 体能↑ 肌肉质量↑	[23]
肝硬化患者	9	有氧运动	8周，3次/周	VO_{2 max}↑ 肌肉质量↑ 疲劳↓	[24]
肝硬化患者	30	有氧运动	6周，3次/周，45 min/次	VO_{2 max}↑ 肌肉质量↑	[25]
肝硬化患者	19	有氧运动	3个月，3次/周，30 min/次	上臂围↑ 肌肉质量↑	[26]
肝硬化患者	39	抗阻运动	12周，3次/周	肌肉力量↑ 生活质量评分↑	[27]
肝硬化患者	13	抗阻运动	12周，2次/周，20 min/次	VO_{2 max}↑ 肌肉力量↑ 肌肉质量↑	[28]
肝硬化患者	-	抗阻运动	2~3次/周，45~60 min/次	肌肉力量↑ 肌肉质量↑	[29]
注：“-”表示文献中无相关数据；VO_{2 max}表示最大摄氧量；“↑”表示上升；“↓”表示下降。

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参考文献(47)

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