槐耳制剂辅助治疗肝细胞癌的作用机制及其临床应用进展

谢铠岭; 徐锋

doi:10.3969/j.issn.1001-5256.2022.03.038

槐耳制剂辅助治疗肝细胞癌的作用机制及其临床应用进展

DOI: 10.3969/j.issn.1001-5256.2022.03.038

谢铠岭,
徐锋^, ,

中国医科大学附属盛京医院普通外科，沈阳 110004

基金项目:

辽宁省自然科学基金 (20180551193);

辽宁省自然科学基金 (2020-MS-181);

盛京医院345人才工程计划 (40B)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：谢铠岭负责文献查找与整理，撰写文章；徐锋负责拟定写作思路，提供意见，修改文章并最终定稿。

详细信息

通信作者:
徐锋，xufengsjh@126.com

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出版历程
- 收稿日期: 2021-07-30
- 录用日期: 2021-10-08
- 出版日期: 2022-03-20

Mechanism of action of Huaier granules in treatment of hepatocellular carcinoma and advances in its clinical application

Kailing XIE,
Feng XU^{,
,}

Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China

Research funding:

Natural Science Foundation of Liaoning Province (20180551193);

Natural Science Foundation of Liaoning Province (2020-MS-181);

345 Talent Project of Shengjing Hospital (40B)

More Information

Corresponding author: XU Feng, xufengsjh@126.com(ORCID: 0000-0001-9985-6527)

摘要

摘要: 肝细胞癌(HCC)是我国第二大疾病相关死亡原因，严重威胁着居民健康。近年研究证明中医药在HCC综合治疗中发挥了重要作用。槐耳制剂现已被推荐用于HCC的治疗，其作用机制包括抑制血管生成、抑制HCC细胞增殖、抑制侵袭与转移、诱导细胞凋亡、调节免疫功能等。本文总结了槐耳抗HCC机理研究和槐耳颗粒在临床中的应用进展，以期为后续研究和临床治疗提供参考。
- 癌, 肝细胞 /
- 槐耳颗粒 /
- 治疗学
Abstract: Hepatocellular carcinoma (HCC) is the second leading cause of disease-related death in China and greatly threatens the health of residents. Recent studies have shown that traditional Chinese medicine plays an important role in the comprehensive treatment of HCC. Huaier granules have been recommended for the treatment of HCC, and its mechanism of action includes inhibiting angiogenesis, inhibiting the proliferation of HCC cells, inhibiting invasion and metastasis, inducing cell apoptosis, and regulating immune function. This article summarizes the research advances in the anti-HCC mechanism of Huaier granules and its application in clinical practice, in order to provide a reference for subsequent research and clinical treatment.
- Carcinoma, Hepatocellular /
- Huaier Granules /
- Therapeutics

HTML全文

图 1 槐耳抗HCC作用机制

注：TLR4，Toll样受体4；N-cadherin，钙黏蛋白N；E-cadherin，钙黏蛋白E；LaminB1，核纤层蛋白；NOV，肾母细胞过表达基因；MAPK，丝裂原活化蛋白激酶；JNK，c-Jun氨基末端激酶；ERK，细胞外调节蛋白激酶；PI3K，磷脂酰肌醇激酶；AKT，丝/苏氨酸蛋白激酶；AEG-1 shRNA，星形胶质细胞提高基因短发夹RNA；CDK，细胞周期蛋白依赖性激酶；Cyclin，细胞周期调节蛋白；NO，一氧化氮；IL-6，白细胞介素6；COX-2，环氧化酶-2；TNFα，肿瘤坏死因子α；Bcl-2，B淋巴细胞瘤-2基因；BAX，Bcl-2基因家族中的一员；G1、S、G2、M，细胞周期4个阶段；Cry61，半胱氨酸蛋白61；CTGF，结缔组织生长因子；Runx2，Runx2家族转录因子2；TEAD2，转录增强缔合域蛋白2；OXA，奥沙利铂。

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