外泌体在肝细胞癌发生发展中的作用及潜在临床价值

罗业浩; 许栋涵; 吕挺; 赵铁建; 汪磊

doi:10.3969/j.issn.1001-5256.2022.03.041

外泌体在肝细胞癌发生发展中的作用及潜在临床价值

DOI: 10.3969/j.issn.1001-5256.2022.03.041

罗业浩¹,
许栋涵²,
吕挺³,
赵铁建¹,
汪磊^4, , ,

1.
广西中医药大学壮医方药基础与应用研究重点实验室，南宁 530200
2.
澳门科技大学中医学院，澳门 999078
3.
湖北民族大学医学部，湖北恩施 445000
4.
广西中医药大学赛恩斯新医药学院，南宁 530200

基金项目:

国家自然科学基金 (81660705);

国家自然科学基金 (81960751)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：罗业浩负责课题设计，资料分析及撰写论文；许栋涵、吕挺参与收集数据及修改论文；赵铁建、汪磊负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
汪磊，292910793@qq.com

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- 被引次数: 0
出版历程
- 收稿日期: 2021-07-17
- 录用日期: 2021-08-02
- 出版日期: 2022-03-20

Role and potential clinical value of exosomes in the development and progression of hepatocellular carcinoma

1.
Key Laboratory of Zhuang Medicine Prescriptions Basis and Application Research, Guangxi University of Chinese Medicine, Nanning 530200, China
2.
School of Traditional Chinese Medicine, Macau University of Science and Technology, Macau, 999078, China
3.
School of Medicine, Hubei University for Nationalities, Enshi, Hubei 445000, China
4.
Faculty of Chinese Medicine Science, Guangxi University of Chinese Medicine, Nanning 530200, China

Research funding:

National Natural Science Foundation of China (81660705);

National Natural Science Foundation of China (81960751)

More Information

Corresponding author: WANG Lei, 292910793@qq.com(ORCID: 0000-0002-2746-4425)

摘要

摘要: 外泌体具有促癌和抑癌的双重特性，其可通过改变肿瘤微环境，促进新生血管生成，调节上皮间质转化使肝癌细胞发生增殖、侵袭和转移。外泌体同样可调节各种生理和病理过程，从而对肝细胞癌具有调控作用，抑制肝癌细胞生长及转移，进而在临床诊断与治疗中发挥重要作用。指出通过免疫调节、重塑肿瘤微循环等可使外泌体成为有效的抗肿瘤治疗方式。
- 外泌体 /
- 癌, 肝细胞 /
- 肿瘤微环境
Abstract: Exosomes have the dual characteristics of promoting and inhibiting cancer and can induce the proliferation, invasion, and metastasis of hepatoma cells by altering tumor microenvironment, promoting neovascularization, and regulating epithelial-mesenchymal transition. Exosomes can regulate hepatocellular carcinoma and inhibit the growth and metastasis of hepatoma cells by regulating a variety of physiological and pathological processes, thus playing an important role in clinical diagnosis and treatment. It is pointed out that exosomes may become an effective antitumor treatment method through immune regulation and remodeling of tumor microcirculation.
- Exosomes /
- Carcinoma, Hepatocellular /
- Tumor Microenvironment

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图 1 外泌体的组成及参与HCC的形成和发展

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