MAPK信号通路——肝棘球蚴病治疗新靶点

董琳琳; 芦永良; 鄂维建; 张翔; 赵玲莉

doi:10.3969/j.issn.1001-5256.2022.03.045

MAPK信号通路——肝棘球蚴病治疗新靶点

DOI: 10.3969/j.issn.1001-5256.2022.03.045

1.
青海大学临床医学院，西宁 810000
2.
青海大学附属医院检验科，西宁 810000

基金项目:

青海省科技基础研究计划项目 (2018-ZJ-757)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：董琳琳负责课题设计，资料分析，撰写论文；芦永良、鄂维建、张翔参与收集资料，修改论文；赵玲莉负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
赵玲莉，zhaolingli640521@163.com

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出版历程
- 收稿日期: 2021-08-04
- 录用日期: 2021-09-30
- 出版日期: 2022-03-20

The MAPK signaling pathway: A new target for the treatment of hepatic echinococcosis

1.
Qinghai University, Xining 810000, China
2.
Department of Clinical Laboratory, The Affiliated Hospital of Qinghai University, Xining 810000, China

Research funding:

Qinghai Science And Technology Basic Research Program (2018-ZJ-757)

More Information

Corresponding author: ZHAO Lingli, zhaolingli640521@163.com(ORCID: 0000-0001-7412-6595)

摘要

摘要: MAPK信号通路可介导多种细胞因子参与炎症、癌症、免疫紊乱和神经退行性疾病等过程，其在肝棘球蚴病发生发展过程中也发挥重要作用。本文回顾了MAPK信号通路的结构及调节过程，重点阐述了肝棘球蚴病中MAPK信号通路的作用，即MAPK信号通路在肝棘球蚴病中存在虫体与宿主的双重激活，参与了疾病的发生、发展过程，并对其治疗产生影响，以MAPK信号通路为靶点的药物治疗有望成为肝棘球蚴病治疗新的策略。
- 棘球蚴病，肝 /
- 丝裂原激活蛋白激酶类 /
- MAP激酶信号系统
Abstract: The MAPK signaling pathway can mediate a variety of cytokines to participate in the processes of inflammation, cancer, immune disorder, and neurodegenerative diseases, and it also plays an important role in the development and progression of hepatic echinococcosis. This article reviews the structure and regulation of the MAPK signaling pathway and elaborates on the role of the MAPK signaling pathway in hepatic echinococcosis. It is pointed out that the MAPK signaling pathway can activate both the cyst and the host in hepatic echinococcosis, participate in the development and progression of the disease, and exert an impact on its treatment. Drug therapy targeting the MAPK signaling pathway is expected to become a new strategy for the treatment of hepatic echinococcosis.
- Echinococcosis, Hepatic /
- Mitogen-Activated Protein Kinases /
- MAP Kinase Signaling System

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图 1 MAPK信号通路示意图

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表 1 目前已在棘球蚴中鉴定的相关MAPK基因、蛋白质及其功能

棘球蚴类别	基因	蛋白质	功能	参考文献
多房棘球蚴	EmRas	EmRas	小GTP家族；Ras家族	[25]
	EmRal	EmRal	小GTP家族；Ras家族	[34]
	EmRaf	EmRaf	MAPKKK，Raf家族	[25]
	EmMKK2	EmMKK2	MAPKK，MEK1/2家族	[27]
	EmMPK1	EmMPK1	MAPK，ERK家族	[26]
	EmMKK1	EmMKK1	MAPKK，MEK3/6家族	[27]
	EmMPK2	EmMPK2	MAPK，P38家族	[28]
	EmMPK3	EmMPK3	MAPK，JUK家族	[35]
细粒棘球蚴	EgRas	EgRas	小GTP家族；Ras家族	[29]
	EgRal	EgRal	小GTP家族；Ras家族	[30]
	EgRaf	EgRaf	MAPKKK，Raf家族	[32]
	EgMKK2	EgMKK2	MAPKK，MEK1/2家族	[32]
	EgERK1	EgERK1	MAPK，ERK家族	[31]
	EgMKK 1	EgMKK1	MAPKK，MEK3/6家族	[32]
	EgP38	EgP38	MAPK，P38家族	[33]

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