遗传性球形红细胞增多症合并Gilbert综合征1例报告

张玉姣; 郑英; 王秀红; 蔡颖; 马安林

doi:10.3969/j.issn.1001-5256.2022.04.029

遗传性球形红细胞增多症合并Gilbert综合征1例报告

DOI: 10.3969/j.issn.1001-5256.2022.04.029

张玉姣^1a,
郑英^{1a, 2},
王秀红^1b,
蔡颖^1c,
马安林^1a, , ,

1a.
中日友好医院感染疾病科，北京 100029
1b.
中日友好医院病理科，北京 100029
1c.
中日友好医院检验科，北京 100029
2.
解放军联勤保障部队第九四〇医院消化内科，兰州 730050

基金项目:

国家重点研发计划“主动健康和老龄化科技应对”重点专项 (2020YFC2004803)

伦理学声明：本例报告已获得患者知情同意。

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：张玉姣、郑英参与病例资料分析并起草文章; 王秀红、蔡颖、马安林参与修改文章关键内容。

详细信息

通信作者:
马安林，maanlinjc@163.com

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出版历程
- 收稿日期: 2021-08-08
- 出版日期: 2022-04-20

Hereditary spherocytosis coexisting with Gilbert's syndrome: A case report

Yujiao ZHANG^1a,
Ying ZHENG^{1a, 2},
Xiuhong WANG^1b,
Ying CAI^1c,
Anlin MA^{1a
, ,
,}

1a.
Department of Infectious Disease, China-Japan Friendship Hospital, Beijing 100029, China
1b.
Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, China
1c.
Department of Clinical Laboratory, China-Japan Friendship Hospital, Beijing 100029, China
2.
Department of Gastroenterology, 940 Hospital of Joint Logistic Support Force of PLA, Lanzhou 730050, China

Research funding:

National Key R & D Program of China (2020YFC2004803)

More Information

Corresponding author: MA Anlin, maanlinjc@163.com(ORCID: 0000-0002-9661-1441)

摘要

- 球形红细胞增多，遗传性 /
- 吉尔伯特病 /
- 黄疸
- Spherocytosis, Hereditary /
- Gilbert Disease /
- Jaundice

HTML全文

图 1 患者外周血涂片(瑞氏染色，×1000)

注：红色箭头示球形红细胞，表现为密集的球状红细胞，中央淡染区丢失；蓝色箭头示多染色性网织红细胞。

Figure 1. Peripheral blood smear (Wright's staining, ×1000)

下载: 全尺寸图片幻灯片

图 2 基因检测结果

Figure 2. Genetic testing results

下载: 全尺寸图片幻灯片

图 3 肝脏病理结果(HE染色，×400)

注：中央静脉周围部分肝细胞内见脂褐素沉积。

Figure 3. Liver pathological results (hematoxylin-eosin staining, ×400)

下载: 全尺寸图片幻灯片

参考文献(11)

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[4]	KANG LL, LIU ZL, ZHANG HD. Gilbert's syndrome coexisting with hereditary spherocytosis might not be rare: Six case reports[J]. World J Clin Cases, 2020, 8(10): 2001-2008. DOI: 10.12998/wjcc.v8.i10.2001.
[5]	STRASSBURG CP, MANNS MP. Jaundice, genes and promoters[J]. J Hepatol, 2000, 33(3): 476-479. DOI: 10.1016/s0168-8278(00)80285-8.
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[8]	BLACK M, BILLING BH. Hepatic bilirubin udp-glucuronyl transferase activity in liver disease and Gilbert's syndrome[J]. N Engl J Med, 1969, 280(23): 1266-1271. DOI: 10.1056/NEJM196906052802303.
[9]	BARCELLINI W, FATTIZZO B. Clinical applications of hemolytic markers in the differential diagnosis and management of hemolytic anemia[J]. Dis Markers, 2015, 2015: 635670. DOI: 10.1155/2015/635670.
[10]	ARIAS IM, GARTNER LM, COHEN M, et al. Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency. Clinical, biochemical, pharmacologic and genetic evidence for heterogeneity[J]. Am J Med, 1969, 47(3): 395-409. DOI: 10.1016/0002-9343(69)90224-1.
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