铁死亡在胆管癌中的作用机制

杨铭钰; 杨震; 任万华

doi:10.3969/j.issn.1001-5256.2022.04.043

铁死亡在胆管癌中的作用机制

DOI: 10.3969/j.issn.1001-5256.2022.04.043

山东第一医科大学附属省立医院感染性疾病科，济南 250000

基金项目:

国家自然科学基金 (81972606);

山东省自然科学基金 (ZR2019MH005)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：杨铭钰负责收集数据，撰写论文；杨震、任万华负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
杨震，uclnn@hotmail.com

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出版历程
- 收稿日期: 2021-08-11
- 录用日期: 2021-09-22
- 出版日期: 2022-04-20

Mechanism of action of ferroptosis in cholangiocarcinoma

Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250000, China

Research funding:

National Natural Science Foundation of China (81972606);

Shandong Provincial Natural Science Foundation of China (ZR2019MH005)

More Information

Corresponding author: YANG Zhen, uclnn@hotmail.com(ORCID: 0000-0003-2199-7789)

摘要

摘要: 胆管癌发病率和死亡率不断上升，研究探索新的治疗靶点具有重要意义。铁死亡是一种新型的铁依赖性细胞氧化损伤的细胞死亡方式，与癌症中的铁代谢及氧化应激失衡密切相关，已成为肿瘤领域的研究热点。介绍了铁死亡相关机制，并在此基础上分析铁死亡参与胆管癌发生发展的研究进展，阐明探讨铁死亡相关调控机制在胆管癌恶性进展过程中的作用具有重要临床价值。
- 胆管肿瘤 /
- 铁死亡 /
- 病理过程
Abstract: The incidence and mortality rates of cholangiocarcinoma (CCA) are increasing constantly, and it is of great importance to explore new therapeutic targets. Ferroptosis, a unique pattern of cell death caused by iron-dependent cellular oxidative injury, is closely associated with iron metabolism and oxidative stress imbalance in cancer and has become a research hotspot in the field of tumor. This article introduces the mechanism of ferroptosis and the research advances in ferroptosis involved in the development and progression of CCA, and it is pointed out that the regulatory mechanism of ferroptosis has an important clinical value in the malignant progression of CCA.
- Bile Duct Neoplasms /
- Ferroptosis /
- Pathologic Processes

HTML全文

图 1 细胞铁死亡调控机制示意图

注：ACSL4，长链酰基辅酶a合成酶家族成员4; ALOX-15，花生四烯酸-15脂氧合酶; CoQ10，辅酶Q10; Cysteine，半胱氨酸; Cystine，胱氨酸; Ferritin，铁蛋白; Ferritinophage，铁自噬; FSP1，铁死亡调控蛋白1; Glutamate，谷氨酸; GSSG，氧化型谷胱甘肽; LIP，不稳定铁池; LOX，脂氧合酶; LPCAT3，溶血磷脂酰胆碱酰基转移酶3; NADPH，还原型烟酰胺腺嘌呤二核苷酸磷酸; NFE2L2，红细胞衍生核因子2样蛋白2; NRF2，核因子E2相关因子2; PUFA，多不饱和脂肪酸; SAT1，精胺N1-乙酰转移酶1; SLC3A2，溶质载体家族3成员2; SLC7A11，溶质载体家族7成员11; Transferrin，转铁蛋白; TfR1，转铁蛋白受体1。

Figure 1. The schematic diagram of ferroptosis regulation mechanism

下载: 全尺寸图片幻灯片

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