肠道菌群与慢性乙型肝炎发生发展及预后的关系

郭紫薇; 张嘉鑫; 李硕; 李晓斌; 朱顺; 靳茜; 李小科; 叶永安

doi:10.3969/j.issn.1001-5256.2022.05.034

肠道菌群与慢性乙型肝炎发生发展及预后的关系

DOI: 10.3969/j.issn.1001-5256.2022.05.034

郭紫薇^{1, 2},
张嘉鑫¹,
李硕^{1, 2},
李晓斌^{1, 2},
朱顺^{1, 2},
靳茜^{1, 2},
李小科^1, , ,,
叶永安^1, , ,

1.
北京中医药大学东直门医院脾胃病科，北京 100700
2.
北京中医药大学第一临床医学院，北京 100029

基金项目:

国家科技重大专项“十三五”课题 (2018ZX10725505);

国家自然科学基金青年科学基金项目 (81804033)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：郭紫薇、张嘉鑫、李硕负责设计研究，资料分析，撰写论文; 郭紫薇、朱顺、李晓斌、靳茜参与检索文献，数据提取，修改论文; 李小科、叶永安负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
李小科，lixiaoke@vip.163.com

叶永安，yeyongan@vip.163.com

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出版历程
- 收稿日期: 2021-09-19
- 出版日期: 2022-05-20

Research advances in intestinal flora and the development and prognosis of chronic hepatitis B

Ziwei GUO^{1, 2},
Jiaxin ZHANG¹,
Shuo LI^{1, 2},
Xiaobin LI^{1, 2},
Shun ZHU^{1, 2},
Qian JIN^{1, 2},
Xiaoke LI^{1
, ,
,},
Yongan YE^{1
, ,
,}

1.
Department of Gastroenterology and Hepatology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
2.
The First Clinical Medical College of Beijing University of Chinese Medicine, Beijing 100029, China

Research funding:

National Science and Technology Major Project "13th Five-Year" (2018ZX10725505);

National Natural Science Foundation of China Youth Science Fund Project (81804033)

More Information

Corresponding author: LI Xiaoke, lixiaoke@vip.163.com(ORCID: 0000-0002-1775-3063); YE Yongan, yeyongan@vip.163.com (ORCID: 0000-0001-9765-4665)

摘要

摘要: 肠道菌群与慢性乙型肝炎(CHB)存在密切关系。近年研究表明，肠道菌群的失调与CHB病情的发生、发展及预后有关，且随着疾病的进展，肠道菌群环境也可能发生变化，二者相互影响，相互作用。本文综述了肠道菌群影响CHB及其相关肝病的病情发展和菌群的调节在CHB及其相关肝病诊治中的作用，以期为CHB的临床治疗提供新思路。
- 乙型肝炎, 慢性 /
- 肝硬化 /
- 胃肠道微生物组 /
- 粪菌移植
Abstract: Intestinal flora is closely associated with chronic hepatitis B (CHB). Recent studies have shown that the imbalance of intestinal flora is associated with the development, progression, and prognosis of CHB, and the environment of intestinal flora may also change with disease progression, suggesting that intestinal flora and CHB interact with each other. This article reviews the influence of intestinal flora on the progression of CHB and related liver diseases and the role of intestinal flora regulation in the diagnosis and treatment of CHB and related liver diseases, in order to provide new ideas for the clinical treatment of CHB.
- Hepatitis B, Chronic /
- Liver Cirrhosis /
- Gastrointestinal Microbiome /
- Fecal Microbiota Transplantation

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参考文献(59)

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