铁死亡的发生机制及其在非酒精性脂肪性肝病/非酒精性脂肪性肝炎发生发展中的作用

刘鸣昊; 刘素彤; 张丽慧; 顾亚娇; 尚东方; 肖准; 赵文霞

doi:10.3969/j.issn.1001-5256.2022.05.037

铁死亡的发生机制及其在非酒精性脂肪性肝病/非酒精性脂肪性肝炎发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2022.05.037

河南中医药大学第一附属医院脾胃肝胆科，郑州 450000

基金项目:

国家自然科学基金 (81904154);

河南省科技攻关计划 (202102310168);

河南省重点研发与推广专项课题 (192102310425);

河南省中医药科学研究专项课题 (2019JDZX2051);

河南省科技攻关计划项目 (202102310495);

河南省特色骨干学科中医学学科建设项目 (STG-ZYXKY-2020024)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：赵文霞负责拟定题目和文章框架：刘素彤负责撰写论文; 张丽慧、顾亚娇、尚东方、肖准负责修改论文; 刘鸣昊负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
赵文霞，zhao-wenxia@163.com

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出版历程
- 收稿日期: 2022-01-20
- 出版日期: 2022-05-20

Mechanism of ferroptosis in the formation of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China

Research funding:

National Natural Science Foundation of China (81904154);

The Science and Technology Research Program of Henan Province (202102310168);

Key Research and Promotion Project of Henan Province (192102310425);

Traditional Chinese Medicine Science Research Project of Henan Province (2019JDZX2051);

Key Science and Technology Project of Henan Province (202102310495);

TCM Discipline Construction Project of Characteristic Backbone Disciplines of Henan Province (STG-ZYXKY-2020024)

More Information

Corresponding author: ZHAO Wenxia, zhao-wenxia@163.com(ORCID: 0000-0001-6666-9469)

摘要

摘要: 铁死亡是脂质过氧化驱动、铁依赖的细胞死亡。发生机制与铁稳态失衡、脂质过氧化及SLC7A11-GSH-GPX4抗氧化系统有关。在非酒精性脂肪性肝病(NAFLD)/非酒精性脂肪性肝炎(NASH)的发生发展中发挥关键作用。抑制铁死亡，几乎可以完全抑制NASH发生。通过对铁死亡发生机制及其在NAFLD/NASH疾病中的作用和进展进行综述，并提出铁死亡研究的策略和技术手段，以期为NAFLD/NASH机制研究提供参考。
- 非酒精性脂肪性肝病 /
- 铁死亡 /
- 脂质过氧化
Abstract: Ferroptosis is a type of iron-dependent cell death driven by lipid peroxidation, and its mechanism is associated with iron homeostasis imbalance, lipid peroxidation, and slC7A11-GSH-GPX4 antioxidant system. Ferroptosis plays a key role in the development and progression of nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH), and inhibition of ferroptosis can almost completely inhibit the development of NASH. This article reviews the research advances in the mechanism of ferroptosis and its role in NAFLD/NASH and proposes the research strategies and technical means for ferroptosis, so as to provide a reference for research on the mechanism of NAFLD/NASH.
- Non-alcoholic Fatty Liver Disease /
- Iron Death /
- Lipid Peroxidation

HTML全文

图 1 铁死亡的发生机制

注：a, System Xc—GSH-GPX4轴与铁死亡发生机制; b，脂质过氧化与铁死亡发生机制; c，铁稳态失衡与铁死亡发生机制。NCOA4，自噬特异性识别蛋白核受体辅激活因子4;TCA循环，三羧酸循环; Fe²⁺，二价亚铁离子; Fe³⁺，三价铁离子; GSH，谷胱甘肽; GPX4，谷胱甘肽过氧化酶4。

Figure 1. The mechanism of ferroptosis

下载: 全尺寸图片幻灯片

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