运动诱导细胞自噬在非酒精性脂肪性肝病防治中的作用

廖粤生; 白莉莉

doi:10.3969/j.issn.1001-5256.2022.05.038

运动诱导细胞自噬在非酒精性脂肪性肝病防治中的作用

DOI: 10.3969/j.issn.1001-5256.2022.05.038

廖粤生,
白莉莉^, ,

天津师范大学体育科学学院，天津 300387

基金项目:

国家社会科学基金重大项目 (19ZDA353);

国家社会科学基金青年项目 (20CTY004)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：廖粤生负责课题设计，收集与分析资料，撰写和修改论文; 白莉莉负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
白莉莉，blx0305@163.com

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出版历程
- 收稿日期: 2021-08-22
- 出版日期: 2022-05-20

Role of exercise-induced autophagy in prevention and treatment of nonalcoholic fatty liver disease

Yuesheng LIAO,
Lili BAI^{,
,}

School of Physical Sciences, Tianjin Normal University, Tianjin 300387, China

Research funding:

National Social Science Fund of China (19ZDA353);

Youth Program of National Social Science Foundation of China (20CTY004)

More Information

Corresponding author: BAI Lili, blx0305@163.com(ORCID: 0000-0002-2216-8723)

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)是一种以慢性肝损伤为主要特征的代谢性疾病。流行病学调查显示，NAFLD的发病率呈现不断上升的趋势，已严重威胁人类的生命健康。研究表明，自噬失调是NAFLD的重要病理生理机制，运动作为一种重要的非药物治疗手段，可通过诱导细胞自噬起到防治NAFLD的作用，但其确切机制尚不清楚。本文梳理与总结自噬与NAFLD的关系、运动诱导细胞自噬对NAFLD的影响以及其潜在分子机制的相关理论研究和应用成果，以期为NAFLD的预防与治疗提供理论参考。
- 非酒精性脂肪性肝病 /
- 自噬 /
- 运动
Abstract: Nonalcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by chronic liver damage. Epidemiological surveys have shown that the incidence rate of NAFLD is increasing constantly and NAFLD has become a serious threat to human life and health. Studies have shown that autophagy dysregulation is an important pathophysiological mechanism of NAFLD, and exercise, as an important non-pharmacological treatment, can prevent and treat NAFLD by inducing autophagy, but its exact mechanism is still unclear. This article summarizes the theoretical studies and application results related to the association between autophagy and NAFLD, the effect of exercise-induced autophagy on NAFLD, and its potential molecular mechanism, in order to provide a theoretical reference for the prevention and treatment of NAFLD.
- Non-alcoholic Fatty Liver Disease /
- Autophagy /
- Exercise

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图 1 运动诱导细胞自噬防治NAFLD的分子机制

Figure 1. Molecular mechanism of exercise-induced autophagy in the prevention and treatment of NAFLD

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表 1 不同运动类型/周期诱导细胞自噬对NAFLD的影响

Table 1. Effects of outophagy induced by different exercise types/cycles on NAFLD

研究对象	运动类型/周期	研究结果	文献
小鼠	有氧运动	Atg6↑, p62↓细胞自噬水平↑	[23]
小鼠	有氧运动	细胞自噬水平↑	[24]
小鼠	抗阻运动	AKT Thr308↑，mTOR Ser2448↑，ULK1 Ser757↑, 细胞自噬水平↓	[26]
大鼠	抗阻运动	细胞自噬水平↓	[27]
大鼠	抗阻运动	LC3Ⅱ↑，Beclin1↑，Atg7↑细胞自噬水平↑	[28]
小鼠	一次跑台训练(50 min，12.3 m/min)	LC3Ⅱ↓，Beclin1↓，Atg↓，AMP2↓细胞自噬水平↓	[29]
小鼠	一次跑台训练(90 min，55% VO_2max)	LC3Ⅱ↑，LC3Ⅱ/LC3Ⅰ↑细胞自噬水平↑	[30]
运动员	一次有氧运动(55%VO_2max; 70%VO_2max)	LC3Ⅱ/LC3Ⅰ↓，p62不变; LC3Ⅱ/ LC3Ⅰ↑，p62↓	[31]
小鼠	4周有氧运动	LC3Ⅱ↑，LC3Ⅱ/LC3Ⅰ↑，Beclin1↑，Bnip3↑，Atg7↑，p62↓细胞自噬水平↑	[32]
大鼠	8周有氧运动(5次/周，60 min/次，25 m/min)	Beclin1↑，LC3Ⅱ↑细胞自噬水平↑	[33]
注：↑表示上升; ↓表示下降。

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