胸腺基质淋巴细胞生成素在肝脏疾病中的作用

陈文赏; 朱继金; 李仕来

doi:10.3969/j.issn.1001-5256.2022.05.042

胸腺基质淋巴细胞生成素在肝脏疾病中的作用

DOI: 10.3969/j.issn.1001-5256.2022.05.042

广西医科大学第一附属医院急诊科，南宁 530021

基金项目:

国家自然科学基金 (81960358)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：陈文赏负责课题设计，文献查阅及收集，撰写论文，修改论文等；朱继金负责指导课题设计，论文写作及修改过程等；李仕来负责确认选题，协助论文修改等。

详细信息

通信作者:
朱继金，zhujijin63@vip.sina.com

计量
- 文章访问数: 848
- HTML全文浏览量: 124
- PDF下载量: 38
- 被引次数: 0
出版历程
- 收稿日期: 2021-09-12
- 录用日期: 2021-10-27
- 出版日期: 2022-05-20

Role of thymic stromal lymphopoietin in liver diseases

Department of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China

Research funding:

National Natural Science Foundation of China (81960358)

More Information

Corresponding author: ZHU Jijin, zhujijin63@vip.sina.com(ORCID: 0000-0001-6419-1350)

摘要

摘要: 胸腺基质淋巴细胞生成素(TSLP)是一种由四条短链的α螺旋束组成的Ⅰ型IL-2家族细胞因子，与IL-7具有同源性。TSLP在很多过敏性疾病或自身免疫性疾病如哮喘、特应性皮炎、嗜酸性食管炎、炎症性肠病等具有重要作用，且促进了这些疾病的发展。目前，也有一些关于TSLP与肝脏疾病的研究报道。关于它在肝脏疾病中作用，有报道其能促进肝脏疾病的发生发展，但也有研究表明其在肝脏疾病中起到保护性的作用。现从TSLP的分子组成及其生物学特性、TSLP与良性肝病、TSLP与肝脏肿瘤三个方面做一综述，阐述TSLP在肝脏疾病中作用的研究进展。
- 肝疾病 /
- 胸腺基质淋巴细胞生成素 /
- 信号传导
Abstract: Thymic stromal lymphopoietin (TSLP) is a type I interleukin 2 family cytokine composed of four short-chain α-helix bundles and has homology with interleukin-7. TSLP plays an important role in many allergic diseases or autoimmune diseases, such as asthma, atopic dermatitis, eosinophilic esophagitis, and inflammatory bowel disease, and promotes the development of these diseases. At present, there are some reports on TSLP in liver diseases, and some studies showed that it can promote the development and progression of liver diseases, while others showed that it plays a protective role in liver diseases. This article reviews the molecular composition and biological features of TSLP and the role of TSLP in benign liver diseases and liver tumors and elaborates on the research advances in TSLP in liver diseases.
- Liver Diseases /
- Thymus Stromal Lymphopoietin /
- Signal Transductron

HTML全文

参考文献(49)

[1]	HE R, GEHA RS. Thymic stromal lymphopoietin[J]. Ann N Y Acad Sci, 2010, 1183: 13-24. DOI: 10.1111/j.1749-6632.2009.05128.x.
[2]	MITCHELL PD, O'Byrne PM. Biologics and the lung: TSLP and other epithelial cell-derived cytokines in asthma[J]. Pharmacol Ther, 2017, 169: 104-112. DOI: 10.1016/j.pharmthera.2016.06.009.
[3]	VERSTRAETE K, PEELMAN F, BRAUN H, et al. Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma[J]. Nat Commun, 2017, 8: 14937. DOI: 10.1038/ncomms14937.
[4]	MATERA MG, ROGLIANI P, CALZETTA L, et al. TSLP inhibitors for asthma: Current status and future prospects[J]. Drugs, 2020, 80(5): 449-458. DOI: 10.1007/s40265-020-01273-4.
[5]	TSILINGIRI K, FORNASA G, RESCIGNO M. Thymic stromal lymphopoietin: To cut a long story short[J]. Cell Mol Gastroenterol Hepatol, 2017, 3(2): 174-182. DOI: 10.1016/j.jcmgh.2017.01.005.
[6]	PROCTOR WR, CHAKRABORTY M, FULLERTON AM, et al. Thymic stromal lymphopoietin and interleukin-4 mediate the pathogenesis of halothane-induced liver injury in mice[J]. Hepatology, 2014, 60(5): 1741-1752. DOI: 10.1002/hep.27169.
[7]	LO KUAN E, ZIEGLER SF. Thymic stromal lymphopoietin and cancer[J]. J Immunol, 2014, 193(9): 4283-4288. DOI: 10.4049/jimmunol.1400864.
[8]	ROAN F, BELL BD, STOKLASEK TA, et al. The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond[J]. J Leukoc Biol, 2012, 91(6): 877-886. DOI: 10.1189/jlb.1211622.
[9]	MARKOVIĆ I, SAVVIDES SN. Modulation of signaling mediated by TSLP and IL-7 in inflammation, autoimmune diseases, and cancer[J]. Front Immunol, 2020, 11: 1557. DOI: 10.3389/fimmu.2020.01557.
[10]	PROCTOR WR, CHAKRABORTY M, CHEA LS, et al. Eosinophils mediate the pathogenesis of halothane-induced liver injury in mice[J]. Hepatology, 2013, 57(5): 2026-2036. DOI: 10.1002/hep.26196.
[11]	ZHOU B, COMEAU MR, de SMEDT T, et al. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice[J]. Nat Immunol, 2005, 6(10): 1047-1053. DOI: 10.1038/ni1247.
[12]	HE R, OYOSHI MK, GARIBYAN L, et al. TSLP acts on infiltrating effector T cells to drive allergic skin inflammation[J]. Proc Natl Acad Sci U S A, 2008, 105(33): 11875-11880. DOI: 10.1073/pnas.0801532105.
[13]	JARUGA B, HONG F, SUN R, et al. Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: Up-regulating eotaxins and IL-5 and recruiting leukocytes[J]. J Immunol, 2003, 171(6): 3233-3244. DOI: 10.4049/jimmunol.171.6.3233.
[14]	RYAN PM, BOURDI M, KORRAPATI MC, et al. Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice[J]. Chem Res Toxicol, 2012, 25(1): 83-93. DOI: 10.1021/tx2003992.
[15]	LI S, YI Z, DENG M, et al. TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway[J]. JCI Insight, 2019, 4(22). DOI: 10.1172/jci.insight.129013.
[16]	GORDON S. Alternative activation of macrophages[J]. Nat Rev Immunol, 2003, 3(1): 23-35. DOI: 10.1038/nri978.
[17]	ONYILAGHA C, SINGH R, GOUNNI AS, et al. Thymic stromal lymphopoietin is critical for regulation of proinflammatory cytokine response and resistance to experimental trypanosoma congolense infection[J]. Front Immunol, 2017, 8: 803. DOI: 10.3389/fimmu.2017.00803.
[18]	BAETSELIER PD, NAMANGALA B, NOЁL W, et al. Alternative versus classical macrophage activation during experimental African trypanosomosis[J]. Int J Parasitol, 2001, 31(5-6): 575-587. DOI: 10.1016/s0020-7519(01)00170-9.
[19]	LEE HC, SUNG SS, KRUEGER PD, et al. Hepatitis C virus promotes T-helper (Th)17 responses through thymic stromal lymphopoietin production by infected hepatocytes[J]. Hepatology, 2013, 57(4): 1314-1324. DOI: 10.1002/hep.26128.
[20]	RONG G, ZHOU Y, XIONG Y, et al. Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: The serum cytokine profile and peripheral cell population[J]. Clin Exp Immunol, 2009, 156(2): 217-25. DOI: 10.1111/j.1365-2249.2009.03898.x.
[21]	TANAKA J, WATANABE N, KIDO M, et al. Human TSLP and TLR3 ligands promote differentiation of Th17 cells with a central memory phenotype under Th2-polarizing conditions[J]. Clin Exp Allergy, 2009, 39(1): 89-100. DOI: 10.1111/j.1365-2222.2008.03151.x.
[22]	SANSONNO D, RUSSI S, SANSONNO S, et al. Thymic stromal lymphopoietin in hepatitis C virus-related cryoglobulinemic vasculitis: Gene expression level and protein distribution[J]. Arthritis Res Ther, 2015, 17(1): 62. DOI: 10.1186/s13075-015-0581-x.
[23]	PILIPONSKY AM, LAHIRI A, TRUONG P, et al. Thymic stromal lymphopoietin improves survival and reduces inflammation in sepsis[J]. Am J Respir Cell Mol Biol, 2016, 55(2): 264-274. DOI: 10.1165/rcmb.2015-0380OC.
[24]	WANG H, NI HM, CHAO X, et al. Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice[J]. Redox Biol, 2019, 22: 101148. DOI: 10.1016/j.redox.2019.101148.
[25]	COLLISON AM, SOKULSKY LA, SHERRILL JD, et al. TNF-related apoptosis-inducing ligand (TRAIL) regulates midline-1, thymic stromal lymphopoietin, inflammation, and remodeling in experimental eosinophilic esophagitis[J]. J Allergy Clin Immunol, 2015, 136(4): 971-982. DOI: 10.1016/j.jaci.2015.03.031.
[26]	NOMURA K, KOJIMA T, FUCHIMOTO J, et al. Regulation of interleukin-33 and thymic stromal lymphopoietin in human nasal fibroblasts by proinflammatory cytokines[J]. Laryngoscope, 2012, 122(6): 1185-1192. DOI: 10.1002/lary.23261.
[27]	LI L, TANG S, TANG X. Thymic stromal lymphopoietin promotes fibrosis and activates mitogen-activated protein kinases in MRC-5 cells[J]. Med Sci Monit, 2016, 22: 2357-2362. DOI: 10.12659/msm.896390.
[28]	INOUE T, FUJISHIMA S, IKEDA E, et al. CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis[J]. Eur Respir J, 2004, 24(1): 49-56. DOI: 10.1183/09031936.04.00110203.
[29]	YING G, ZHANG Y, TANG G, et al. Functions of thymic stromal lymphopoietin in non-allergic diseases[J]. Cell Immunol, 2015, 295(2): 144-149. DOI: 10.1016/j.cellimm.2015.03.006.
[30]	FORBES SJ, PAROLA M. Liver fibrogenic cells[J]. Best Pract Res Clin Gastroenterol, 2011, 25(2): 207-217. DOI: 10.1016/j.bpg.2011.02.006.
[31]	DATTA A, ALEXANDER R, SULIKOWSKI MG, et al. Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease[J]. J Immunol, 2013, 191(9): 4867-4879. DOI: 10.4049/jimmunol.1300588.
[32]	FORKEL M, BERGLIN L, KEKÄLÄINEN E, et al. Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers[J]. Eur J Immunol, 2017, 47(8): 1280-1294. DOI: 10.1002/eji.201646890.
[33]	KOWALEWSKA J, MVHLFELD AS, HUDKINS KL, et al. Thymic stromal lymphopoietin transgenic mice develop cryoglobulinemia and hepatitis with similarities to human hepatitis C liver disease[J]. Am J Pathol, 2007, 170(3): 981-989. DOI: 10.2353/ajpath.2007.060474.
[34]	TANEDA S, SEGERER S, HUDKINS KL, et al. Cryoglobulinemic glomerulonephritis in thymic stromal lymphopoietin transgenic mice[J]. Am J Pathol, 2001, 159(6): 2355-2369. DOI: 10.1016/S0002-9440(10)63085-4.
[35]	YOO J, OMORI M, GYARMATI D, et al. Hepatitis C, cryoglobulinemia, and cirrhosis: a meta-analysis[J]. Hepatology, 2002, 36: 978-985. DOI: 10.1053/jhep.2002.35620.
[36]	SAADOUN D, ASSELAH T, RESCHE-RIGON M, et al. Cryoglobulinemia is associated with steatosis and fibrosis in chronic hepatitis C[J]. Hepatology, 2006, 43(6): 1337-1345. DOI: 10.1002/hep.21190.
[37]	YOO J, OMORI M, GYARMATI D, et al. Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin[J]. J Exp Med, 2005, 202(4): 541-549. DOI: 10.1084/jem.20041503.
[38]	LISZEWSKI MK, FARRIES TC, LUBLIN DM, et al. Control of the complement system[J]. Adv Immunol, 1996, 61: 201-283. DOI: 10.1016/s0065-2776(08)60868-8.
[39]	MVHLFELD AS, SEGERER S, HUDKINS K, et al. Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis[J]. Kidney Int, 2004, 65(4): 1214-1223. DOI: 10.1111/j.1523-1755.2004.00495.x.
[40]	ZHOU C, WANG P, LEI L, et al. Overexpression of miR-142-5p inhibits the progression of nonalcoholic steatohepatitis by targeting TSLP and inhibiting JAK-STAT signaling pathway[J]. Aging (Albany NY), 2020, 12(10): 9066-9084. DOI: 10.18632/aging.103172.
[41]	VARRICCHI G, PECORARO A, MARONE G, et al. Thymic stromal lymphopoietin isoforms, inflammatory disorders, and cancer[J]. Front Immunol, 2018, 9: 1595. DOI: 10.3389/fimmu.2018.01595.
[42]	VARRICCHI G, GALDIERO MR, LOFFREDO S, et al. Are mast cells masters in cancer?[J]. Front Immunol, 2017, 8: 424. DOI: 10.3389/fimmu.2017.00424.
[43]	VARRICCHI G, GALDIERO MR, MARONE G, et al. Controversial role of mast cells in skin cancers[J]. Exp Dermatol, 2017, 26(1): 11-17. DOI: 10.1111/exd.13107.
[44]	YUAN Q, YAO F, ZHOU L, et al. Yu Ping Feng San Exert anti-angiogenesis effects through the inhibition of TSLP-STAT3 signaling pathways in hepatocellular carcinoma[J]. Evid Based Complement Alternat Med, 2019, 2019: 1947156. DOI: 10.1155/2019/1947156.
[45]	XIE F, MENG YH, LIU LB, et al. Cervical carcinoma cells stimulate the angiogenesis through TSLP promoting growth and activation of vascular endothelial cells[J]. Am J Reprod Immunol, 2013, 70(1): 69-79. DOI: 10.1111/aji.12104.
[46]	KUAN EL, ZIEGLER SF. A tumor-myeloid cell axis, mediated via the cytokines IL-1α and TSLP, promotes the progression of breast cancer[J]. Nat Immunol, 2018, 19(4): 366-374. DOI: 10.1038/s41590-018-0066-6.
[47]	YAO F, YUAN Q, SONG X, et al. Yupingfeng granule improves Th2-biased immune state in microenvironment of hepatocellular carcinoma through TSLP-DC-OX40L pathway[J]. Evid Based Complement Alternat Med, 2020, 2020: 1263053. DOI: 10.1155/2020/1263053.
[48]	DEMEHRI S, CUNNINGHAM TJ, MANIVASAGAM S, et al. Thymic stromal lymphopoietin blocks early stages of breast carcinogenesis[J]. J Clin Invest, 2016, 126(4): 1458-1470. DOI: 10.1172/JCI83724.
[49]	YUE W, LIN Y, YANG X, et al. Thymic stromal lymphopoietin (TSLP) inhibits human colon tumor growth by promoting apoptosis of tumor cells[J]. Oncotarget, 2016, 7(13): 16840-16854. DOI: 10.18632/oncotarget.7614.