急性胰腺炎发生急性肾损伤的早期预测指标

王岩; 李明政; 刘玉凤; 王世明

doi:10.3969/j.issn.1001-5256.2022.05.046

急性胰腺炎发生急性肾损伤的早期预测指标

DOI: 10.3969/j.issn.1001-5256.2022.05.046

王岩¹,
李明政¹,
刘玉凤¹,
王世明^2, , ,

1.
山西医科大学研究生院，太原 030001
2.
山西医科大学第一医院普通外科，太原 030001

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：王岩负责拟定写作思路，设计论文提纲及论文撰写; 王岩、李明政、刘玉凤负责论文查阅及相关数据对比分析; 王世明负责修改论文，指导撰写文章并最后定稿。

详细信息

通信作者:
王世明，wangshimingsx@sina.com

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- 被引次数: 0
出版历程
- 收稿日期: 2021-09-01
- 录用日期: 2021-10-17
- 出版日期: 2022-05-20

Early predictors for acute kidney injury in acute pancreatitis

1.
Graduate School, Shanxi Medical University, Taiyuan 030001, China
2.
Department of General Surgery, The First Hospital of Shanxi Medical University, Taiyuan 030001, China

More Information

Corresponding author: WANG Shiming, wangshimingsx@sina.com(ORCID: 0000-0002-9054-0646)

摘要

摘要: 急性胰腺炎(AP)是消化系统常见的急腹症之一，尽早治疗避免加重至重症急性胰腺炎(SAP)是保证预后的关键，AP合并急性肾损伤(AKI)，使胰腺炎死亡率显著增加。早诊断AP并发AKI，是降低病死率的重中之重。本文综述了现有关于AP发生AKI早期预测指标的相关研究，相互比较，简述了中性粒细胞与淋巴细胞比率、胱抑素C、肾血管阻力指数、中性粒细胞明胶酶相关性脂质运载蛋白等常用指标以及其他有价值的指标，认为依据不同标志物的敏感度和特异度，多标志物联合诊断AP早期AKI是一大前景。
- 胰腺炎, 急性坏死性 /
- 急性肾损伤 /
- 炎症 /
- 早期诊断
Abstract: Acute pancreatitis (AP) is one of the common acute abdominal diseases of the digestive system, and early treatment to avoid aggravation to severe pancreatitis (SAP) is the key to guaranteeing prognosis. AP with acute kidney injury (AKI) can significantly increase the mortality rate of pancreatitis. Early diagnosis of AP with AKI is a top priority to reduce mortality rate. This article reviews the current studies on the early predictors for AKI in AP and briefly describes commonly used indicators (neutrophil-to-lymphocyte ratio, cystatin C, renal vascular resistance index, and neutrophil gelatinase-associated lipocalin) and other valuable indicators. It is pointed out that a combination of various markers based on their sensitivity and specificity has a promising future in the diagnosis of AKI in AP.
- Pancreatitis, Acute Necrotizing /
- Acute Kidney Injury /
- Inflammation /
- Early Diagnosis

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参考文献(52)

[1]	ZHENG X, HE WH, LYU NH. International reseach progress on acute pancreatitis in 2018[J]. Chin J Pancreatol, 2019, 19(4): 241-244. DOI: 10.3760/cma.j.issn.1674-1935.2019.04.001. 郑西, 何文华, 吕农华. 2018年国际急性胰腺炎研究进展[J]. 中华胰腺病杂志, 2019, 19(4): 241-244. DOI: 10.3760/cma.j.issn.1674-1935.2019.04.001.
[2]	Pancreas Study Group, Chinese Society of Gastroenterology, Chinese Medical Association, Editorial Board of Chinese Journal of Pancreatology, Editorial Board of Chinese Journal of Digestion. Chinese guidelines for the management of acute pancreatitis (Shenyang, 2019)[J]. J Clin Hepatol, 2019, 35(12): 2706-2711. DOI: 10.3969/j.issn.1001-5256.2019.12.013. 中华医学会消化病学分会胰腺疾病学组, 《中华胰腺病杂志》编委会, 《中华消化杂志》编委会. 中国急性胰腺炎诊治指南(2019年, 沈阳)[J]. 临床肝胆病杂志, 2019, 35(12): 2706-2711. DOI: 10.3969/j.issn.1001-5256.2019.12.013.
[3]	ESCOBAR-ARELLANO R, GURAIEB-BARRAGÁN E, MANSANARES-HERNÁNDEZ A, et al. Sensitivity, specificity and reliability of the POP score vs. APACHE Ⅱ score as predictors of severe acute biliary pancreatitis[J]. Cir Cir, 2019, 87(4): 402-409. DOI: 10.24875/CIRU.18000662.
[4]	NASSAR TI, QUNIBI WY. AKI associated with acute pancreatitis[J]. Clin J Am Soc Nephrol, 2019, 14(7): 1106-1115. DOI: 10.2215/CJN.13191118.
[5]	ZHENG CM, WANG ZJ, DOU HH. The influence of Shenfu injection on the expression of P38 MAPK protein and inflammatory factors in rats with severe acute pancreatitis complicated with acute renal injury[J]. J Qiqihar Med Coll, 2019, 40(14): 1721-1724. DOI: 10.3969/j.issn.1002-1256.2019.14.002. 郑传明, 王振杰, 窦贺贺. 参附注射液对重症急性胰腺炎大鼠合并急性肾损伤p38 MAPK蛋白表达及其炎性因子的影响[J]. 齐齐哈尔医学院学报, 2019, 40(14): 1721-1724. DOI: 10.3969/j.issn.1002-1256.2019.14.002.
[6]	SHAO GJ, WANG L, LIU Q, et al. The diagnostic value of neutrophil-to-lymphocyte rate (NLR) in acute pancreatitis related acute kidney injury patients[J]. Chin J Pancreatol, 2016, 16(3): 181-184. DOI: 10.3760/cma.j.issn.1674-1935.2016.03.009. 邵国建, 王雷, 刘琦, 等. 中性粒细胞与淋巴细胞比值在急性胰腺炎并发急性肾损伤患者病情诊断中的价值[J]. 中华胰腺病杂志, 2016, 16(3): 181-184. DOI: 10.3760/cma.j.issn.1674-1935.2016.03.009.
[7]	ZHANG ZQ, WEI MB, WANG BY, et al. The predictive value of NLR, RDW and C-reactive protein for acute pancreatitis with severe acute kidney injury[J]. J Clin Nephrol, 2020, 20(11): 891-896. DOI: 10.3969/j.issn.1671-2390.2020.11.008. 张治琴, 魏茂碧, 王白莹, 等. 中性粒细胞/淋巴细胞比值、红细胞分布宽度联合C反应蛋白对急性胰腺炎并发严重急性肾损伤的预测价值[J]. 临床肾脏病杂志, 2020, 20(11): 891-896. DOI: 10.3969/j.issn.1671-2390.2020.11.008.
[8]	WU LL, TANG EY, SHI L. The prognostic value of neutrophil/lymphocyte ratio in patients with acute pancreatitis[J]. Modern Practical Medicine, 2018, 30(9): 1149-1150, 1239. DOI: 10.3969/j.issn.1671-0800.2018.09.014. 伍利利, 唐恩燕, 石亮. 中性粒细胞与淋巴细胞比值预测急性胰腺炎患者发生急性肾损伤的价值分析[J]. 现代实用医学, 2018, 30(9): 1149-1150, 1239. DOI: 10.3969/j.issn.1671-0800.2018.09.014.
[9]	WEI MB, ZHANG ZQ, MA Z, et al. Ratios of neutrophil, lymphocyte and monocyte to high-density lipoprotein cholesterol in acute pan-creatitis complicated with acute kidney injury[J]. J Clin Nephrol, 2021, 21(1): 1-9. DOI: 10.3969/j.issn.1671-2390.m20-147. 魏茂碧, 张治琴, 马洲, 等. 全血细胞计数和高密度脂蛋白胆固醇之比与急性胰腺炎相关急性肾损伤的临床研究[J]. 临床肾脏病杂志, 2021, 21(1): 1-9. DOI: 10.3969/j.issn.1671-2390.m20-147.
[10]	LIEW FY, GIRARD JP, TURNQUIST HR. Interleukin-33 in health and disease[J]. Nat Rev Immunol, 2016, 16(11): 676-689. DOI: 10.1038/nri.2016.95.
[11]	WANG X, LIANG L, YAO BH. Variations of serum IL-33 and sST2 levels in patients with acute pancreatitis and its clinical significance[J]. J Dalian Med Univ, 2015, 37(6): 537-540. DOI: 10.11724/jdmu.2015.06.05. 王欣, 梁鲁, 姚碧辉. 急性胰腺炎患者血清IL-33及sST2水平变化及临床意义[J]. 大连医科大学学报, 2015, 37(6): 537-540. DOI: 10.11724/jdmu.2015.06.05.
[12]	CHEN WL, DUAN JF, BAI LL, et al. Role of NF-κB, IL-33 and sST2 in acute renal injury following acute pancreatitis[J]. Chin J Curr Adv Gen Surg, 2018, 21(10): 778-782. DOI: 10.3969/j.issn.1009-9905.2018.10.005. 陈文亮, 段俊芳, 白露露, 等. NF-κB、IL-33及sST2在急性胰腺炎合并急性肾损伤中的价值研究[J]. 中国现代普通外科进展, 2018, 21(10): 778-782. DOI: 10.3969/j.issn.1009-9905.2018.10.005.
[13]	HUANG X, ZHANG LJ, WANG P. Predictive value of serum miR-10a and IL-33 levels in patients with se-vere acute pancreatitis complicated with acute kidney injury[J]. China Med Herald, 2021, 18(4): 29-32. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY202104008.htm 黄鲜, 张丽涓, 王平. 血清miR-10a、IL-33水平对重症急性胰腺炎患者并发急性肾损伤的预测价值[J]. 中国医药导报, 2021, 18(4): 29-32. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY202104008.htm
[14]	ZHANG XH, LI ML, WANG B, et al. Caspase-1 inhibition alleviates acute renal injury in rats with severe acute pancreatitis[J]. World J Gastroenterol, 2014, 20(30): 10457-10463. DOI: 10.3748/wjg.v20.i30.10457.
[15]	WANG H, CAI ZF, AO DS, et al. Urinary IL-18 and NGAL as early biomarkers of acute kidney injury following adult severe acute pancreatitis[J]. J Immunol, 2012, 28(7): 642-644. https://www.cnki.com.cn/Article/CJFDTOTAL-MYXZ201207022.htm 王虹, 蔡治方, 敖弟书, 等. 尿IL-18及NGAL在重症急性胰腺炎患者并发急性肾损伤的早期诊断价值[J]. 免疫学杂志, 2012, 28(7): 642-644. https://www.cnki.com.cn/Article/CJFDTOTAL-MYXZ201207022.htm
[16]	MALMSTRØM ML, HANSEN MB, ANDERSEN AM, et al. Cytokines and organ failure in acute pancreatitis: Inflammatory response in acute pancreatitis[J]. Pancreas, 2012, 41(2): 271-277. DOI: 10.1097/MPA.0b013e3182240552.
[17]	PRASADA R, MUKTESH G, SAMANTA J, et al. Natural history and profile of selective cytokines in patients of acute pancreatitis with acute kidney injury[J]. Cytokine, 2020, 133: 155177. DOI: 10.1016/j.cyto.2020.155177.
[18]	FU CP, HUANG LY, YANG L. Expression of CX3CR1 in acute kidney injury associated with acute pancreatitis in rats[J]. World Chin J Digestol, 2015, 23(10): 1553-1559. DOI: 10.11569/wcjd.v23.i10.1553. 付春萍, 黄李雅, 杨力. CX3CR1在大鼠重症急性胰腺炎继发急性肾损伤中的表达及作用[J]. 世界华人消化杂志, 2015, 23(10): 1553-1559. DOI: 10.11569/wcjd.v23.i10.1553.
[19]	TONG Q, HOU YY, TIAN Y, et al. Clinical significance of urinary NGAL, Scr and Cys C in the diagnosis of sepsis complicated with acute kidney injury[J]. Chin J Lab Diag, 201, 25(3): 398-400. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSZD202103028.htm 佟庆, 侯燕燕, 田颖, 等. 尿NGAL、Scr、Cys C在脓毒血症并发急性肾损伤诊断中的价值研究[J]. 中国实验诊断学, 2021, 25(3): 398-400. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSZD202103028.htm
[20]	CHEN YQ, JIANG X, XU H, et al. Value of serum cystatin C in predicting acute kidney injury in patients with acute pancreatitis[J]. Chin J Clin Hepatol, 2020, 36(11): 2505-2508. DOI: 10.3969/j.issn.1001-5256.2020.11.021. 陈雨晴, 蒋鑫, 徐欢, 等. 血清胱抑素C对急性胰腺炎并发急性肾损伤的预测价值[J]. 临床肝胆病杂志, 2020, 36(11): 2505-2508. DOI: 10.3969/j.issn.1001-5256.2020.11.021.
[21]	CHAI X, HUANG HB, FENG G, et al. Baseline serum cystatin C is a potential predictor for acute kidney injury in patients with acute pancreatitis[J]. Dis Markers, 2018, 2018: 8431219. DOI: 10.1155/2018/8431219.
[22]	HUANG Y, DON-WAUCHOPE AC. The clinical utility of kidney injury molecule 1 in the prediction, diagnosis and prognosis of acute kidney injury: A systematic review[J]. Inflamm Allergy Drug Targets, 2011, 10(4): 260-271. DOI: 10.2174/187152811796117735.
[23]	KARAGÖZ F, SIT D, KIRANKAYA A, et al. The predictive role of new markers in early diagnosis of acute kidney injury in patients with acute pancreatitis[J]. Open J Nephrol, 2020, 10, 254-263. DOI: 10.4236/ojneph.2020.103025.
[24]	SHAO X, TIAN L, XU W, et al. Diagnostic value of urinary kidney injury molecule 1 for acute kidney injury: A meta-analysis[J]. PLoS One, 2014, 9(1): e84131. DOI: 10.1371/journal.pone.0084131.
[25]	CHENG XY, WANG L. Predictive value of APACHEⅡ score combined with urinary neutrophil gelatinase-associated apolipoprotein in sepsis combined with acute kidney injury[J]. Clin Misdiagn Misther, 2020, 33(6): 57-62. DOI: 10.3969/j.issn.1002-3429.2020.06.014. 程晓迎, 王磊. APACHEⅡ评分联合尿中性粒细胞明胶酶相关载脂蛋白检测对脓毒症合并急性肾损伤的预测价值[J]. 临床误诊误治, 2020, 33(6): 57-62. DOI: 10.3969/j.issn.1002-3429.2020.06.014.
[26]	ZHOU HL, FU Y, HUANG YQ. Correlation of plasma lipocalin-2 with inflammation and predictive value of lipocalin-2 for detecting acute kidney injury in acute pancreatitis[J]. West China Med J, 2020, 35(11): 1350-1356. DOI: 10.7507/1002-0179.201910043. 周皓岚, 付英, 黄元庆. 血清脂质运载蛋白-2与炎症反应的关系及其对急性胰腺炎合并急性肾损伤的预测价值[J]. 华西医学, 2020, 35(11): 1350-1356. DOI: 10.7507/1002-0179.201910043.
[27]	CHEN YH, WU YH, YU HM, et al. Neutrophil gelatinase associated lipocalin in prediction of acute kidney injury following severe acute pancreatitis[J]. J Clin Nephrol, 2018, 18(5): 281-284. DOI: 10.3969/j.issn.1671-2390.2018.05.006. 陈艳红, 吴艳红, 于海明, 等. 中性粒细胞明胶酶相关载脂蛋白在重症急性胰腺炎合并急性肾损伤中的意义[J]. 临床肾脏病杂志, 2018, 18(5): 281-284. DOI: 10.3969/j.issn.1671-2390.2018.05.006.
[28]	WU S, ZHOU YL, LI ZJ. Predictive value of serum LCN2 and Cys C levels in acute pancreatitis complicated with acute kidney injury[J]. Shandong Med J, 2021, 61(25): 6-9, 22. DOI: 10.3969/j.issn.1002-266X.2021.25.002. 吴松, 周依林, 李治君. 血清LCN2、Cys C水平对急性胰腺炎并发急性肾损伤的预测价值[J]. 山东医药, 2021, 61(25): 6-9, 22. DOI: 10.3969/j.issn.1002-266X.2021.25.002.
[29]	ORENES-PIÑERO E, MANZANO-FERNÁNDEZ S, LÑPEZ-CUENCA Á, et al. β-Trace protein: from GFR marker to cardiovascular risk predictor[J]. Clin J Am Soc Nephrol, 2013, 8(5): 873-881. DOI: 10.2215/CJN.08870812.
[30]	WAJDA J, DUMNICKA P, SPOREK M, et al. Does Beta-Trace Protein (BTP) outperform cystatin C as a diagnostic marker of acute kidney injury complicating the early phase of acute pancreatitis?[J]. J Clin Med, 2020, 9(1): 205. DOI: 10.3390/jcm9010205.
[31]	BLEYER AJ, KMOCH S. Tamm horsfall glycoprotein and uromodulin: It is all about the Tubules![J]. Clin J Am Soc Nephrol, 2016, 11(1): 6-8. DOI: 10.2215/CJN.12201115.
[32]	RISCH L, LHOTTA K, MEIER D, et al. The serum uromodulin level is associated with kidney function[J]. Clin Chem Lab Med, 2014, 52(12): 1755-1761. DOI: 10.1515/cclm-2014-0505.
[33]	WANG YH, WU GK, ZHENG RJ, et al. Clinical significance of serum UMOD on prediction of acute kidney injury in patients with acute pancreatitis[J]. Chin J Crit Care Med, 2019, 39(10): 958-962. DOI: 10.3969/j.issn.1002-1949.2019.10.008. 王宇涵, 吴贵恺, 郑荣娟, 等. 血清尿调节素在急性胰腺炎早期急性肾损伤患者外周血中的表达及临床意义[J]. 中国急救医学, 2019, 39(10): 958-962. DOI: 10.3969/j.issn.1002-1949.2019.10.008.
[34]	Pancreatic Surgery Group, Surgical Society of Chinese Medical Association. Guidelines for diagnosis and treatment of acute pancreatitis in China (2021)[J]. Chin J Dig Surg, 2021, 20(7): 730-739. DOI: 10.3760/cma.j.cn115610-20210622-00297. 中华医学会外科学分会胰腺外科学组. 中国急性胰腺炎诊治指南(2021)[J]. 中华消化外科杂志, 2021, 20(7): 730-739. DOI: 10.3760/cma.j.cn115610-20210622-00297.
[35]	HAITSMA MULIER J, ROZEMEIJER S, RÖTTGERING JG, et al. Renal resistive index as an early predictor and discriminator of acute kidney injury in critically ill patients; A prospective observational cohort study[J]. PLoS One, 2018, 13(6): e0197967. DOI: 10.1371/journal.pone.0197967.
[36]	WU J, XU ZW, ZHANG H, et al. Clinical study on the early predictive value of renal resistive index in acute kidney injury associated with severe acute pancreatitis[J]. Chin Critical Care Med, 2019, 31(8): 998-1003. DOI: 10.3760/cma.j.issn.2095-4352.2019.08.017. 武钧, 许志伟, 张泓, 等. 肾血管阻力指数对重症急性胰腺炎相关性急性肾损伤早期预测价值的临床研究[J]. 中华危重病急救医学, 2019, 31(8): 998-1003. DOI: 10.3760/cma.j.issn.2095-4352.2019.08.017.
[37]	LV Y, YAO Y, LIU Q, et al. Accuracy of angiopoietin-2 for predicting organ failure in patients with acute pancreatitis: a systematic review and meta-analysis[J]. J Int Med Res, 2021, 49(2): 300060520986708. DOI: 10.1177/0300060520986708.
[38]	SPOREK M, DUMNICKA P, GALA-BLADZINSKA A, et al. Angiopoietin-2 is an early indicator of acute pancreatic-renal syndrome in patients with acute pancreatitis[J]. Mediators Inflamm, 2016, 2016: 5780903. DOI: 10.1155/2016/5780903.
[39]	ZHOU HY, NING GH, NIE SL. Early predicting value of procalcitonin levels in severe acute pancreatitis combined with acute kidney injury[J]. J Clin Emerg Call, 2015, 16(2): 106-108. DOI: 10.13201/j.issn.1009-5918.2015.02.008. 周海洋, 宁果豪, 聂绍良. 降钙素原对重症急性胰腺炎合并急性肾损伤早期预测作用的研究[J]. 临床急诊杂志, 2015, 16(2): 106-108. DOI: 10.13201/j.issn.1009-5918.2015.02.008.
[40]	HUANG HL, NIE X, CAI B, et al. Procalcitonin levels predict acute kidney injury and prognosis in acute pancreatitis: A prospective study[J]. PLoS One, 2013, 8(12): e82250. DOI: 10.1371/journal.pone.0082250.
[41]	GUO QH, LI ZZ, ZHOU W, et al. Renal vascular resistance index combined with procalcitonin in predicting acute renal injury in patients with acute pancreatitis[J]. J Hepatobil Surg, 2020, 28(1): 56-60. DOI: 10.3969/j.issn.1006-4761.2020.01.016. 郭庆宏, 李志州, 周威, 等. 肾血管阻力指数联合降钙素原对急性胰腺炎患者发生急性肾损伤预测价值[J]. 肝胆外科杂志, 2020, 28(1): 56-60. DOI: 10.3969/j.issn.1006-4761.2020.01.016.
[42]	MUNSHI R, JOHNSON A, SIEW ED, et al. MCP-1 gene activation marks acute kidney injury[J]. J Am Soc Nephrol, 2011, 22(1): 165-175. DOI: 10.1681/ASN.2010060641.
[43]	YANG YZ, XIANG Y, CHEN M, et al. Clinical significance of dynamic detection for serum levels of MCP-1, TNF-α and IL-8 in patients with acute pancreatitis[J]. Asian Pac J Trop Med, 2016, 9(11): 1111-1114. DOI: 10.1016/j.apjtm.2016.09.001.
[44]	KE GB, LIU Z, XU YY, et al. The diagnostic value of L-FABP and NAG in adult severe acute pancreatitis with acute kidney injury[J]. J Modern Clin Med, 2015, 41(4): 263-264, 267. DOI: 10.11851/j.issn.1673-1557.2015.04.008. 柯贵宝, 刘哲, 徐云滢, 等. L-FABP和NAG在重症急性胰腺炎合并急性肾损伤中的早期诊断价值[J]. 现代临床医学, 2015, 41(4): 263-264, 267. DOI: 10.11851/j.issn.1673-1557.2015.04.008.
[45]	YUE YL, CHEN SS, HAN B. The value of ALR and β2-MG combined with Scr in early prediction of severe acute pancreatitis and acute kidney injury[J]. J Guangxi Med Univ, 2019, 36(8): 1309-1313. DOI: 10.16190/j.cnki.45-1211/r.2019.08.021. 岳英丽, 陈珊珊, 韩斌. ALR、β2-MG联合Scr对重症急性胰腺炎合并急性肾损伤的早期预测价值[J]. 广西医科大学学报, 2019, 36(8): 1309-1313. DOI: 10.16190/j.cnki.45-1211/r.2019.08.021.
[46]	ZHANG W, ZHANG L, CHEN YX, et al. Identification of nestin as a urinary biomarker for acute kidney injury[J]. Am J Nephrol, 2014, 39(2): 110-121. DOI: 10.1159/000358260.
[47]	MORALES-BUENROSTRO LE, SALAS-NOLASCO OI, BARRERA-CHIMAL J, et al. Hsp72 is a novel biomarker to predict acute kidney injury in critically ill patients[J]. PLoS One, 2014, 9(10): e109407. DOI: 10.1371/journal.pone.0109407.
[48]	WANG B, JIANG Q, WU X. Association of D-dimers with acute kidney injury in pregnant women: A retrospective study[J]. J Int Med Res, 2020, 48(11): 300060520966899. DOI: 10.1177/0300060520966899.
[49]	ZHOU X, ZHAO KL, YANG B, et al. The study in the level of 1α-hydroxylase in kidney tissue and the variation of serum calcium in rats with severe acute pancreatitis[J]. Chin J Emerg Med, 2014, 23(10): 1088-1092. DOI: 10.3760/cma.j.issn.1671-0282.2014.10.005. 周星, 赵凯亮, 杨波, 等. 重症急性胰腺炎大鼠肾脏1α-羟化酶表达与血钙变化的研究[J]. 中华急诊医学杂志, 2014, 23(10): 1088-1092. DOI: 10.3760/cma.j.issn.1671-0282.2014.10.005.
[50]	MOHAMED W, ASIMAKOPOULOS G. Preoperative C-reactive protein as a predictor of postoperative acute kidney injury in patients undergoing coronary artery bypass grafting[J]. Perfusion, 2021, 36(4): 330-337. DOI: 10.1177/0267659120947684.
[51]	LYU YC, YAO YH, LEI JJ, et al. Value of soluble fms-like tyrosine 1 in early prediction of severity of acute pancreatitis: A systematic review and meta-analysis[J]. World Chin J Dig, 2020, 28(14): 594-604. DOI: 10.11569/WCJDv28.I14.594. 吕永才, 姚燕华, 雷静静, 等. 可溶性fms样酪氨酸激酶-1与急性胰腺炎早期严重程度预测价值的系统评价和meta分析[J]. 世界华人消化杂志, 2020, 28(14): 594-604. DOI: 10.11569/WCJDv28.I14.594.
[52]	LI H, LIU J, WANG W, et al. Matrix metalloproteinase 9 and vasodilator-stimulated phosphoprotein related to acute kidney injury in severe acute pancreatitis rats[J]. Dig Dis Sci, 2015, 60(12): 3647-3655. DOI: 10.1007/s10620-015-3820-8.