肿瘤相关成纤维细胞在胰腺癌治疗耐药中的作用

闫毅; 贾军梅; 郭亚荣

doi:10.3969/j.issn.1001-5256.2022.05.048

肿瘤相关成纤维细胞在胰腺癌治疗耐药中的作用

DOI: 10.3969/j.issn.1001-5256.2022.05.048

闫毅¹,
贾军梅^2, , ,,
郭亚荣²

1.
山西医科大学第一临床医学院，太原 030001
2.
山西医科大学第一医院肿瘤科，太原 030001

基金项目:

山西省2021年度留学人员科技活动择优资助项目 (20210004)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：闫毅负责拟定写作思路，检索文献，撰写论文; 郭亚荣负责课题设计; 贾军梅负责指导、修改论文并最终定稿。

详细信息

通信作者:
贾军梅，jiajunmei1972@163.com

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出版历程
- 收稿日期: 2021-09-03
- 录用日期: 2021-10-11
- 出版日期: 2022-05-20

Role of cancer-associated fibroblasts in drug resistance of pancreatic cancer

Yi YAN¹,
Junmei JIA^{2
, ,
,},
Yarong GUO²

1.
The First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China
2.
Department of Oncology, The First Hospital of Shanxi Medical University, Taiyuan 030001, China

Research funding:

Shanxi Province 2021 Scholarship Program for Science and Technology Activities (20210004)

More Information

Corresponding author: JIA Junmei, jiajunmei1972@163.com(ORCID: 0000-0002-9295-5351)

摘要

摘要: 胰腺癌是致命的恶性肿瘤之一，其致密的间质，占胰腺肿瘤体积的90%，是胰腺癌生存率低的主要原因。肿瘤相关成纤维细胞(CAF)是存在于胰腺癌肿瘤间质中的一类重要细胞群，激活后的CAF引起强烈的促结缔组织间质反应，并分泌多种可溶性分子重塑细胞外基质，形成一个更有利于胰腺癌增殖、侵袭转移的微环境。目前越来越多的证据表明CAF在胰腺癌治疗耐药中扮演着重要的角色，尤其是在化疗和免疫治疗方面，CAF通过干扰抗肿瘤药物的代谢、参与耐药相关信号通路、形成免疫抑制微环境等机制，造成胰腺癌治疗的有效率低。本文将从化疗和免疫治疗两个方面论述CAF参与胰腺癌治疗耐药的具体机制，以期为寻找胰腺癌新的治疗靶点，提高胰腺癌治疗有效率提供新的思路。
- 胰腺肿瘤 /
- 成纤维细胞 /
- 免疫耐受
Abstract: Pancreatic cancer is one of the fatal malignant tumors, and its dense stroma, which accounts for 90% of the volume of pancreatic tumor, is the main reason for the low survival rate of pancreatic cancer. Cancer-associated fibroblasts (CAFs) are an important group of cells in the tumor stroma of pancreatic cancer, and activated CAFs induce a strong connective tissue interstitial reaction and secretes a variety of soluble molecules to remodel the extracellular matrix, thereby forming a microenvironment that helps with the proliferation, invasion, and metastasis of pancreatic cancer. At present, an increasing number of evidence has shown that CAFs play an important role in the drug resistance of pancreatic cancer, especially in chemotherapy and immunotherapy, and CAFs result in a low response rate of pancreatic cancer treatment by interfering with the metabolism of antitumor drugs, participating in the signaling pathways associated with drug resistance, and forming an immunosuppressive microenvironment. This article elaborates on the specific mechanism of CAFs participating in the drug resistance of pancreatic cancer from the two aspects of chemotherapy and immunotherapy, in order to provide new ideas for identifying new therapeutic targets for pancreatic cancer and improving the response rate of pancreatic cancer treatment.
- Pancreatic Neoplasms /
- Fibroblasts /
- Immune Toleranc

HTML全文

图 1 CAF参与化疗耐药

Figure 1. The role of CAF in chemotherapy resistance

下载: 全尺寸图片幻灯片

图 2 CAF参与免疫治疗耐药

Figure 2. The role of CAF in immunotherapy resistance

下载: 全尺寸图片幻灯片

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