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N6-甲基腺苷修饰在HBV感染中的作用
DOI: 10.3969/j.issn.1001-5256.2022.06.034
利益冲突声明：所有作者均声明不存在利益冲突。
作者贡献声明：薛萍负责收集数据，资料分析，撰写论文；范超负责拟定写作思路，指导撰写文章并最后定稿。
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摘要: N6-甲基腺苷(m6A)甲基化修饰现象普遍存在于人体各个组织和细胞中，是真核生物mRNA普遍的内部修饰。m6A修饰是动态可逆的，多种甲基转移酶、去甲基化酶及m6A结合蛋白参与此过程的调控。最近的研究结果表明，m6A修饰可影响病毒基因的表达，尤其在HBV感染过程中发挥着重要的作用。本文简要概括了m6A修饰的研究现状及机制，并重点关注其与HBV感染的关系。阐述了HBV转录物的m6A修饰作用，回顾了m6A参与HBV感染免疫应答的相关研究结果，归纳了HBV感染对宿主细胞m6A修饰及HBV相关肝细胞癌的影响，以期探讨其在HBV感染研究中的发展方向和潜在价值。Abstract: The phenomenon of N6-methyladenosine (m6A)-methylation is commonly observed in various tissues and cells of the human body and is the most common type of internal modification in eukaryotic mRNA. m6A-methylation is dynamic and reversible, which is regulated by various methyltransferases, demethylases, and m6A binding protein. Recent studies have shown that m6A modification can affect viral gene expression and plays an important role in the process of HBV infection. This article summarizes the current research status and mechanism of m6A-methylation, especially its association with HBV infection. This article also elaborates on the effect of m6A modification on HBV transcripts, reviews the research findings of m6A in immune response of HBV infection, and summarizes the effect of HBV infection on m6A modification in normal host hepatocytes and hepatitis B liver cancer, so as to discuss the development direction and potential value of m6A in HBV infection.
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Key words:
- Hepatitis B virus /
- N6-methyladenosine /
- Immune Response
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图 1 m6A修饰的基本过程和参与蛋白
Figure 1. The main process and associated proteins in m6A methylation
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