新型冠状病毒相关自发性脾破裂的诊治

师鸿运; 权盼盼; 褚成龙; 徐露瑶; 刘晓燕; 王英超

doi:10.3969/j.issn.1001-5256.2022.07.046

新型冠状病毒相关自发性脾破裂的诊治

DOI: 10.3969/j.issn.1001-5256.2022.07.046

a.
吉林大学第一医院肝胆胰外二科，长春 130021
b.
吉林大学第一医院心血管病中心内科组，长春 130021

基金项目:

吉林省自然科学基金 (20200201331JC)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：师鸿运负责资料分析，撰写论文; 权盼盼负责收集数据; 徐露瑶、褚成龙、刘晓燕负责文献查找分析，修改论文; 王英超负责设计课题，拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
王英超，wangyingc@jlu.edu.cn

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出版历程
- 收稿日期: 2022-03-26
- 录用日期: 2022-04-28
- 出版日期: 2022-07-20

Diagnosis and treatment of spontaneous splenic rupture associated with severe acute respiratory syndrome coronavirus 2

a.
Second Department of Hepatopancreatobiliary Surgery, The First Hospital of Jilin University, Changchun 130021, China
b.
Internal Medicine Group of Cardiovascular Disease Center, The First Hospital of Jilin University, Changchun 130021, China

Research funding:

Natural Science Foundation of Jilin Province (20200201331JC)

More Information

Corresponding author: WANG Yingchao, wangyingc@jlu.edu.cn(ORCID: 0000-0002-3847-7977)

摘要

摘要: 新型冠状病毒肺炎(COVID-19)是由新型冠状病毒(SARS-CoV-2)感染引起的主要经呼吸道传播的急性病毒性疾病，其不仅侵袭人体呼吸系统，还损伤人体多个器官系统。现已有证据显示SARS-CoV-2与自发性脾破裂之间可能存在因果联系，本文认识到SARS-CoV-2相关性自发性脾破裂发生的可能性，并探讨其发生机制和诊治方案，避免临床上对其漏诊误诊。
- 新型冠状病毒肺炎 /
- 新型冠状病毒 /
- 脾破裂
Abstract: Coronavirus disease 2019 (COVID-19) is an acute viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and is mainly transmitted through the respiratory tract. It not only invades the respiratory system of human body, but also damages various organs and systems. Evidence has shown that there may be a causal association between SARS-CoV-2 and spontaneous splenic rupture. This article recognizes the possibility of SARS-CoV-2-associated spontaneous splenic rupture and discusses its pathogenesis and related diagnosis and treatment regimens, so as to avoid missed diagnosis and misdiagnosis in clinical practice.
- Coronavirus Disease 2019 /
- Severe Acute Respiratory Syndrome Coronavirus 2 /
- Splenic Rupture

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参考文献(37)

[1]	World Health Organization. Coronavirus disease 2019 (COVID-19) situation report[EB/OL]. [2022-3-19]. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports.
[2]	WIERSINGA WJ, RHODES A, CHENG AC, et al. Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review[J]. JAMA, 2020, 324(8): 782-793. DOI: 10.1001/jama.2020.12839.
[3]	HUANG C, WANG Y, LI X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J]. Lancet, 2020, 395(10223): 497-506. DOI: 10.1016/S0140-6736(20)30183-5.
[4]	LAI CC, SHIH TP, KO WC, et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges[J]. Int J Antimicrob Agents, 2020, 55(3): 105924. DOI: 10.1016/j.ijantimicag.2020.105924.
[5]	DING Y, HE L, ZHANG Q, et al. Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways[J]. J Pathol, 2004, 203(2): 622-630. DOI: 10.1002/path.1560.
[6]	WANG T, DU Z, ZHU F, et al. Comorbidities and multi-organ injuries in the treatment of COVID-19[J]. Lancet, 2020, 395(10228): e52. DOI: 10.1016/S0140-6736(20)30558-4.
[7]	ODILOV A, VOLKOV A, ABDULLAEV A, et al. COVID-19: multiorgan dissemination of SARS-CoV-2 is driven by pulmonary factors[J]. Viruses, 2021, 14(1): 39. DOI: 10.3390/v14010039.
[8]	KNEFATI M, GANIM I, SCHMIDT J, et al. COVID-19 with an initial presentation of intraperitoneal hemorrhage secondary to spontaneous splenic rupture[J]. Cureus, 2021, 13(5): e15310. DOI: 10.7759/cureus.15310.
[9]	AGUS M, FERRARA ME, BIANCO P, et al. Atraumatic splenic rupture in a SARS-CoV-2 patient: case report and review of literature[J]. Case Rep Surg, 2021, 2021: 5553619. DOI: 10.1155/2021/5553619.
[10]	SHAUKAT I, KHAN R, DIWAKAR L, et al. Atraumatic splenic rupture due to covid-19 infection[J]. Clin Infect Pract, 2021, 10: 100042. DOI: 10.1016/j.clinpr.2020.100042.
[11]	MOBAYEN M, YOUSEFI S, MOUSAVI M, et al. The presentation of spontaneous splenic rupture in a COVID-19 patient: a case report[J]. BMC Surg, 2020, 20(1): 220. DOI: 10.1186/s12893-020-00887-5.
[12]	KOCAEL PC, SIMSEK O, BILGIN IA, et al. Characteristics of patients with spontaneous splenic rupture[J]. Int Surg, 2014, 99(6): 714-718. DOI: 10.9738/INTSURG-D-14-00143.1.
[13]	GUY S, de CLERCQ S. Splenic rupture in community acquired pneumonia: A case report[J]. Int J Surg Case Rep, 2016, 29: 85-87. DOI: 10.1016/j.ijscr.2016.10.054.
[14]	AL-MASHAT FM, SIBIANY AM, AL AMRI AM. Spontaneous splenic rupture in infectious mononucleosis[J]. Saudi J Gastroenterol, 2003, 9(2): 84-86.
[15]	LEUNG AK, RAFAAT M. Eruption associated with amoxicillin in a patient with infectious mononucleosis[J]. Int J Dermatol, 2003, 42(7): 553-555. DOI: 10.1046/j.1365-4362.2003.01699_1.x.
[16]	WEAVER H, KUMAR V, SPENCER K, et al. Spontaneous splenic rupture: A rare life-threatening condition; Diagnosed early and managed successfully[J]. Am J Case Rep, 2013, 14: 13-15. DOI: 10.12659/AJCR.883739.
[17]	XIANG Q, FENG Z, DIAO B, et al. SARS-CoV-2 induces lymphocytopenia by promoting inflammation and decimates secondary lymphoid organs[J]. Front Immunol, 2021, 12: 661052. DOI: 10.3389/fimmu.2021.661052.
[18]	ABDULLAEV A, ODILOV A, ERSHLER M, et al. Viral load and patterns of SARS-CoV-2 dissemination to the lungs, mediastinal lymph nodes, and spleen of patients with COVID-19 associated lymphopenia[J]. Viruses, 2021, 13(7): 1410. DOI: 10.3390/v13071410.
[19]	HOFFMANN M, KLEINE-WEBER H, SCHROEDER S, et al. SARS-CoV-2 cell entry Depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor[J]. Cell, 2020, 181(2): 271-280. e8. DOI: 10.1016/j.cell.2020.02.052.
[20]	LI MY, LI L, ZHANG Y, et al. Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues[J]. Infect Dis Poverty, 2020, 9(1): 45. DOI: 10.1186/s40249-020-00662-x.
[21]	SUN FF, HE BF, HE Y. Advances on the effects of angiotensin converting enzyme 2 in coronavirus induced lung injury and other lung diseases[J/CD]. Chin J Exp Clin Infect Dis(Electronic Edition), 2021, 15(1): 7-10. DOI: 10.3877/cma.j.issn.1674-1358.2021.01.002. 孙芬芬, 贺斌峰, 何勇. 血管紧张素转化酶2在冠状病毒感染所致肺损伤及其他肺部疾病中研究进展[J/CD]. 中华实验和临床感染病杂志(电子版), 2021, 15(1): 7-10. DOI: 10.3877/cma.j.issn.1674-1358.2021.01.002.
[22]	BROWN SL, DALE DC. Spontaneous splenic rupture following administration of granulocyte colony-stimulating factor (G-CSF): occurrence in an allogeneic donor of peripheral blood stem cells[J]. Biol Blood Marrow Transplant, 1997, 3(6): 341-343.
[23]	MEHTA P, PORTER JC, MANSON JJ, et al. Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities[J]. Lancet Respir Med, 2020, 8(8): 822-830. DOI: 10.1016/S2213-2600(20)30267-8.
[24]	YANG L, LIU S, LIU J, et al. COVID-19: immunopathogenesis and immunotherapeutics[J]. Signal Transduct Target Ther, 2020, 5(1): 128. DOI: 10.1038/s41392-020-00243-2.
[25]	MEHTA P, MCAULEY DF, BROWN M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression[J]. Lancet, 2020, 395(10229): 1033-1034. DOI: 10.1016/S0140-6736(20)30628-0.
[26]	OUDKERK M, BVLLER HR, KUIJPERS D, et al. Diagnosis, prevention, and treatment of thromboembolic complications in COVID-19: report of the national institute for public health of the netherlands[J]. Radiology, 2020, 297(1): E216-E222. DOI: 10.1148/radiol.2020201629.
[27]	DU HB, ZHANG YS, WANG T, et al. Thinking on liver-spleen syndrome differentiation and treatment against Novel coronavious pneumonica[J]. World Chin Med, 2020, 15(3): 348-350. DOI: 10.3969/j.issn.1673-7202.2020.03.009. 杜宏波, 张耀圣, 王彤, 等. 肝脾辨治在新型冠状病毒肺炎诊治中的思考[J]. 世界中医药, 2020, 15(3): 348-350. DOI: 10.3969/j.issn.1673-7202.2020.03.009.
[28]	LYU ZG, GUO JJ, LAN TY, et al. Treatment of a severe COVID-19 case with the method of warmly tonifying the spleen and kidneys, removing toxicity substances and resolving hard masses[J]. J Changchun Univ Chin Med, 2021, 37(6): 1245-1247. DOI: 10.13463/j.cnki.cczyy.2021.06.019. 吕志国, 郭家娟, 兰天野, 等. "温补脾肾, 解毒散结"治疗重型新型冠状病毒肺炎1例[J]. 长春中医药大学学报, 2021, 37(6): 1245-1247. DOI: 10.13463/j.cnki.cczyy.2021.06.019.
[29]	LU S, GU ZS, TAO GS, et al. Stage experience of TCM diagnosis and treatment of Corona Virus Disease 2019[J]. China J Tradit Chin Med Pharm, 2020, 35(3): 1100-1103. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202003016.htm 陆曙, 顾植山, 陶国水, 等. 2019冠状病毒病的中医诊治阶段体会[J]. 中华中医药杂志, 2020, 35(3): 1100-1103. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202003016.htm
[30]	CHEUNG KS, HUNG I, CHAN P, et al. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from a Hong Kong cohort: Systematic review and meta-analysis[J]. Gastroenterology, 2020, 159(1): 81-95. DOI: 10.1053/j.gastro.2020.03.065.
[31]	LI J, HUANG DQ, ZOU B, et al. Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes[J]. J Med Virol, 2021, 93(3): 1449-1458. DOI: 10.1002/jmv.26424.
[32]	ALSAMMAN M, CAGGIULA A, GANGULI S, et al. Non-respiratory presentations of COVID-19, a clinical review[J]. Am J Emerg Med, 2020, 38(11): 2444-2454. DOI: 10.1016/j.ajem.2020.09.054.
[33]	WANG B, ZHU XG, JIANG LH, et al. Diagnosis and treatment of spontaneous splenic rupture in 13 cases[J]. Tianjin Med J, 2019, 47(9): 962-965. DOI: 10.11958/20191083. 王斌, 朱新国, 蒋林华, 等. 自发性脾破裂13例诊治分析[J]. 天津医药, 2019, 47(9): 962-965. DOI: 10.11958/20191083.
[34]	HU MR, XU DZ. Non-traumatic rupture of spleen[J]. J Clin Surg, 2006, 14 (7): 411-412. DOI: 10.3969/j.issn.1005-6483.2006.07.008. 胡铭荣, 徐德征. 自发性脾破裂[J]. 临床外科杂志, 2006, 14 (7): 411-412. DOI: 10.3969/j.issn.1005-6483.2006.07.008.
[35]	RENZULLI P, HOSTETTLER A, SCHOEPFER AM, et al. Systematic review of atraumatic splenic rupture[J]. Br J Surg, 2009, 96(10): 1114-1121. DOI: 10.1002/bjs.6737.
[36]	THAPAR PM, PHILIP R, MASURKAR VG, et al. Laparoscopic splenectomy for spontaneous rupture of the spleen[J]. J Minim Access Surg, 2016, 12(1): 75-78. DOI: 10.4103/0972-9941.158950.
[37]	XU LY, LI CX, TANG CH, et al. Management of patients with gallstones and acute cholecystitis during the epi-demic of coronavirus disease 2019[J]. J Clin Hepatol, 2020, 36(6): 1420-1422. DOI: 10.3969/j.issn.1001-5256.2020.06.051. 徐露瑶, 李昌旭, 唐朝辉, 等. 胆囊结石伴急性胆囊炎患者在新型冠状病毒肺炎疫情期间的防控和诊治[J]. 临床肝胆病杂志, 2020, 36(6): 1420-1422. DOI: 10.3969/j.issn.1001-5256.2020.06.051.