去乙酰化酶Sirtuins家族与非酒精性脂肪性肝病的关系
DOI: 10.3969/j.issn.1001-5256.2022.10.030
利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:宗也凯负责论文设计,收集数据,资料分析,撰写论文并最后定稿; 刘江凯参与论文指导。
Association between the sirtuin family of deacetylases and nonalcoholic fatty liver disease
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摘要: 去乙酰化酶Sirtuins家族广泛存在于人体细胞当中,通过作用于线粒体、内质网和细胞核调节多种蛋白的翻译后化学修饰,对生物代谢过程产生影响,其参与非酒精性脂肪性肝病中的多种病理生理反应。本文对去乙酰化酶Sirtuins家族与非酒精性脂肪性肝病关系的研究进展进行了综述,旨在为今后治疗非酒精性脂肪性肝病提供可能的潜在途径。Abstract: The sirtuin family of deacetylases widely exists in human cells and can regulate the post-translational chemical modification of various proteins by acting on mitochondria, endoplasmic reticulum and nucleus, thereby influencing the process of biological metabolism. The sirtuin family is also involved in a variety of pathophysiological reactions in nonalcoholic fatty liver disease (NAFLD). This article reviews the research advances in the association between the sirtuin family of deacetylases and nonalcoholic fatty liver disease, so as to provide a potential approach for NAFLD treatment in the future.
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Key words:
- Non-alcoholic Fatty Liver Disease /
- Sirtuins /
- Deacetylation
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分型 位置 长度 催化活性 与NAFLD相关功能 SIRT1 细胞核 747 aa 脱乙酰基酶 染色质的形成,线粒体生物发生,脂肪酸氧化,胆固醇和胆汁酸稳态的调节 SIRT2 细胞质 352 aa 脱乙酰基酶
脱嘧啶酶细胞周期调节,促进脂肪细胞的脂肪分解,肿瘤抑制/促进 SIRT3 线粒体 399 aa 脱乙酰基酶 线粒体活性的调节,抗氧化应激活动,肿瘤抑制 SIRT4 线粒体 314 aa 脱乙酰基酶
腺苷二磷酸核糖基转移酶
脂肪酰胺酶葡萄糖代谢,氨基酸分解代谢,肿瘤抑制 SIRT5 线粒体 310 aa 脱乙酰基酶
去琥珀酸酶
去谷氨酰胺酶脂肪酸代谢,氨基酸代谢,尿素循环 SIRT6 细胞核 355 aa 脱乙酰基酶
脱醛酶
腺苷二磷酸核糖基转移酶
脱嘧啶酶基因组稳定性/DNA修复,糖脂代谢,发炎 SIRT7 细胞核 400 aa 脱乙酰基酶
腺苷二磷酸核糖基转移酶核糖体生物发生,肿瘤促进 注:aa,氨基酸。数据库来源:Uniprot,Genecards。 -
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