肝纤维化发生机制及其中药逆转治疗的研究进展
DOI: 10.3969/j.issn.1001-5256.2022.10.033
利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:刘世恒负责课题设计,资料分析,撰写论文; 赵素贤参与修改论文; 张玉果负责拟定写作思路,指导撰写文章并最后定稿。
Recent research progress and mechanisms on Traditional Chinese Medicine reversal therapy of liver fibrosis
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摘要: 肝纤维化是指在各种病因作用下,肝星状细胞被激活,分泌大量的细胞外基质,最终导致肝脏纤维化。早期逆转肝纤维化可以阻止疾病进一步发展,减少终末期肝病和肝癌的发生,本文分别介绍了肝血窦内皮细胞(LSEC)、Notch信号通路、YAP/TAZ信号通路、细胞自噬在逆转肝纤维化方面的作用机制,并列举其各自机制下抗肝纤维化的中药治疗研究进展,以期为逆转肝纤维化提供新的研究思路及中药治疗方法。Abstract: Liver fibrosis occurs due to damages caused by liver diseases of various etiologies and activation of hepatic stellate cells, leading to the repairing and damaging cycle by secreting a large amount of extracellular matrix and formation of fibrosis tissues in the liver. Early reversal of this process could prevent further development and progression of the disease, which may reduce incidence of the end-stage liver disease and even liver cancer. This review summarized and discussed recent advancements and mechanisms of liver sinusoidal endothelial cells, Notch signaling pathway, YAP/TAZ signaling pathway, and autophagy in regulation of liver fibrosis and then enumerated the Traditional Chinese Medicine in reversal of liver fibrosis process and the underlying molecular mechanisms. It expects to provide novel approaches and research ideas for future control of liver fibrosis using Traditional Chinese Medicine.
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Key words:
- Liver Cirrhosis /
- Hepatic Stellate Cells /
- Drugs, Chinese Herbal
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