巨噬细胞极化在非肿瘤性肝脏疾病中的作用机制及其靶向治疗

陈玮钰; 覃小宾; 乐滢玉; 王涵; 隆晓荣; 毛德文

doi:10.3969/j.issn.1001-5256.2022.11.042

巨噬细胞极化在非肿瘤性肝脏疾病中的作用机制及其靶向治疗

DOI: 10.3969/j.issn.1001-5256.2022.11.042

1.
广西中医药大学研究生院, 南宁 530001
2.
广西中医药大学第一附属医院肝病科, 南宁 530023

基金项目:

国家自然科学基金 (81960841);

国家自然科学基金 (82060848);

广西自然科学基金创新研究团队项目 (2018GXNSFGA281002)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：毛德文、陈玮钰负责研究选题并拟定写作思路；覃小宾、乐滢玉负责设计论文框架；王涵、隆晓荣负责收集、整理文献材料；毛德文、陈玮钰负责文章撰写和指导修改。

详细信息

通信作者:
毛德文, mdwboshi2005@163.com

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出版历程
- 收稿日期: 2022-03-31
- 录用日期: 2022-05-14
- 出版日期: 2022-11-20

Mechanism of action of macrophage polarization in non-neoplastic liver diseases and related targeted therapies

1.
Graduate School of Guangxi University of Chinese Medicine, Nanning 530001, China
2.
Department of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

Research funding:

National Natural Science Foundation of China (81960841);

National Natural Science Foundation of China (82060848);

Guangxi Natural Science Foundation Innovation Research Team Project (2018GXNSFGA281002)

More Information

Corresponding author: MAO Dewen, mdwboshi2005@163.com(ORCID: 0000-0001-9438-9325)

摘要

摘要: 巨噬细胞作为重要的免疫细胞，参与维持肝内微环境稳态的关键过程。近年研究发现不同肝脏疾病均可诱发巨噬细胞极化(MPP)，形成功能互为拮抗的M1和M2表型，前者可促进清除病原体和抑制肿瘤进展，后者发挥抗炎和促进组织修复的作用。然而，MPP在不同肝脏疾病或疾病不同病理阶段中的作用机制及表型转换存在明显差异。本文着重介绍了肝内巨噬细胞的起源及其极化特性，归纳探讨MPP在病毒性肝炎、酒精性肝病、非酒精性脂肪性肝病、肝纤维化等非肿瘤性肝病中发病机制和治疗药物的研究进展，旨在挖掘MPP在调控肝脏疾病免疫应答和炎症反应方面的潜力。
- 肝疾病 /
- 巨噬细胞活化 /
- 病理过程 /
- 免疫疗法
Abstract: Macrophages, as important immune cells, are involved in the key processes that maintain the homeostasis of intrahepatic microenvironment. Recent studies have shown that different liver diseases can induce macrophage polarization (MPP) and form M1 and M2 phenotypes with mutual antagonism. The former promotes the clearance of pathogens and inhibits tumor progression, while the latter exerts an anti-inflammatory effect and promotes tissue repair. However, there are significant differences in the mechanism of action and phenotypic switching of MPP in different liver diseases or at different pathological stages of the disease. This article focuses on the origin and polarization characteristics of intrahepatic macrophages and summarizes the research advances in the role of MPP in the pathogenesis and therapeutic drugs of non-neoplastic liver diseases such as viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, and liver fibrosis, in order to explore the potential of MPP in regulating the immune response and inflammatory response of liver diseases.
- Liver Diseases /
- Macrophage Activation /
- Pathologic Processes /
- Immunotherapy

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