胰腺癌患者纳米刀术后心肌损伤的危险因素分析

海珑珠; 胡强夫; 李晓勇; 郭佩垒; 杨玲伟

doi:10.3969/j.issn.1001-5256.2022.12.019

胰腺癌患者纳米刀术后心肌损伤的危险因素分析

DOI: 10.3969/j.issn.1001-5256.2022.12.019

a.
郑州大学第五附属医院麻醉科，郑州 450052
b.
郑州大学第五附属医院肝胆外科，郑州 450052

基金项目:

河南省医学科技攻关计划联合共建项目 (LHGJ20190425)

伦理学声明：本研究方案于2021年12月10日经由郑州大学第五附属医院伦理委员会审批，批号：Y2021050。

利益冲突声明：本研究不存在研究者、伦理委员会成员、受试者监护人以及与公开研究成果有关的利益冲突。

作者贡献声明：海珑珠负责课题设计，资料分析，撰写论文；郭佩垒、杨玲伟参与收集数据，修改论文；李晓勇提供统计学支持；胡强夫拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
胡强夫，huli2004803@sina.com

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出版历程
- 收稿日期: 2022-09-30
- 录用日期: 2022-11-02
- 出版日期: 2022-12-20

Risk factors for myocardial injury after Nano-Knife surgery in patients with pancreatic cancer

a.
Department of Anesthesiology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
b.
Department of Hepatobiliary Surgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

Research funding:

Medical science and Technology project of Henan Province (LHGJ20190425)

More Information

Corresponding author: HU Qiangfu, huli2004803@sina.com (ORCID: 0000-0002-2842-0678)

摘要

摘要: 目的探讨胰腺癌患者纳米刀术后发生心肌损伤的危险因素，并建立预测风险模型的列线图。方法回顾性分析2020年9月—2021年11月于郑州大学第五附属医院行纳米刀治疗的92例胰腺癌患者的临床资料，以术后3天内出现血清肌钙蛋白I＞0.03 ng/mL作为心肌损伤的诊断标准，将患者分为心肌损伤组(n=51)和非心肌损伤组(n=41), 收集所有患者的年龄、性别、BMI、美国麻醉师协会分级、吸烟史、酗酒史、术前合并症等基线资料。计量资料用组间比较采用Mann-Whitney U检验。计数资料组间比较采用χ²检验或Fisher检验。采用单因素和多因素Logistic回归分析筛选有统计学差异的变量，筛选出相关因素建立预测胰腺癌患者纳米刀术后发生心肌损伤风险的列线图。采用受试者工作特征曲线下面积(AUC)评估模型的区分能力和临床效用。结果相较于非心肌损伤组，心肌损伤组消融时间更长(χ²=7.410，P=0.006)，探针数量更多(χ²=6.130，P=0.047), 术前合并高血压(χ²=12.124，P＜0.001)、慢性肾脏病(χ²=12.829，P＜0.001)者更多。单因素Logistic回归分析显示，肿瘤直径、消融时间、手术方式、探针数量、高血压史及慢性肾脏病史均与心肌损伤的发生有关(P值均＜0.05);多因素Logistic回归分析显示，肿瘤直径[比值比(OR)=3.94, 95%CI: 1.09~14.18, P=0.036]、消融时间(OR=4.15, 95%CI: 1.30~13.27, P=0.016)、手术方式(OR=6.92, 95%CI: 1.92~25.07, P=0.003)及合并高血压史(OR=4.07，95%CI: 1.12~14.77, P=0.034)是胰腺癌患者纳米刀术后发生心肌损伤的独立危险因素。AUC=0.859表明，列线图具有较好的区分能力和临床效用。结论胰腺癌患者纳米刀术后心肌损伤发生率较高，术前合并高血压、肿瘤直径＞4 cm、消融时间＞1 h是心肌损伤发生的独立危险因素，手术方式(纳米刀+旁路吻合)能增加心肌损伤的风险，列线图对预测心肌损伤发生的风险有较好效果。
- 胰腺肿瘤 /
- 纳米刀 /
- 心肌疾病
Abstract: Objective To investigate the risk factors for myocardial injury after Nano-Knife surgery in patients with pancreatic cancer, and to establish a nomogram model for risk prediction. Methods A retrospective analysis was performed for the clinical data of 92 patients with pancreatic cancer who underwent Nano-Knife surgery in The Fifth Affiliated Hospital of Zhengzhou University from September 2020 to November 2021, with serum cardiac troponin I > 0.03 ng/mL within 3 days after surgery as the diagnostic criteria for myocardial injury, the patients were divided into myocardial injury group with 51 patients and non-myocardial injury group with 41 patients. Related baseline data were collected for all patients, including age, sex, body mass index, American Society of Anesthesiologists classification, smoking history, alcohol abuse history, and preoperative comorbidities. The Mann-Whitney U test was used for comparison of continuous data between groups, and the chi-square test or the Fisher's exact test was used for comparison of categorical data between groups. Univariate and multivariate logistic regression analyses were used to screen out the variables with statistical significance, and the factors screened out were used to establish a nomogram for predicting the risk of myocardial injury after Nano-Knife surgery in patients with pancreatic cancer. The receiver operating characteristic (ROC) curve and the area under the ROC curve (AUC) were used to evaluate the discriminatory ability and clinical utility of the model. Results Compared with the non-myocardial injury group, the myocardial injury group had a significantly longer ablation time (χ²=7.410, P=0.006), a significantly greater number of probes (χ²=6.130, P=0.047), and a significantly higher proportion of patients with preoperative hypertension (χ²=12.124, P < 0.001) or chronic kidney disease (χ²=12.829, P < 0.001). The univariate logistic regression analysis showed that tumor diameter, ablation time, surgical procedure, number of probes, history of hypertension, and history of chronic kidney disease were associated with the development of myocardial injury (all P < 0.05), and the multivariate logistic regression analysis showed that tumor diameter (odds ratio [OR]= 3.94, 95% confidence interval [CI]: 1.09-14.18, P=0.036), ablation time (OR=4.15, 95%CI: 1.30-13.27, P=0.016), surgical procedure (OR=6.92, 95%CI: 1.92-25.07, P=0.003), and history of hypertension (OR=4.07, 95%CI: 1.12-14.77, P=0.034) were independent risk factors for myocardial injury after Nano-Knife surgery in patients with pancreatic cancer. An AUC of 0.859 showed that the nomogram had good discriminatory ability and clinical utility. Conclusion There is a relatively high incidence rate of myocardial injury after Nano-Knife surgery in patients with pancreatic cancer. Preoperative hypertension, tumor diameter > 4 cm, and ablation time > 1 hour are independent risk factors for myocardial injury, and the surgical procedure of Nano-Knife surgery and bypass anastomosis can increase the risk of myocardial injury. The nomogram has a good effect in predicting the risk of myocardial injury.
- Pancreatic Neoplasms /
- Nano-Knife /
- Cardiomyopathies

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图 1 术中超声引导下布针

Figure 1. Intraoperative ultrasound-guided needle placement

下载: 全尺寸图片幻灯片

图 2 Lasso回归中回归系数随Log(λ)变化曲线

Figure 2. Variation cure of regression coefficient with Log(λ)in Lasso regression

下载: 全尺寸图片幻灯片

图 3 Lasso回归的交叉验证

Figure 3. Cross-validation of Lasso regression

下载: 全尺寸图片幻灯片

图 4 胰腺癌患者纳米刀术后发生心肌损伤列线图

Figure 4. Nomogram of myocardial injury after nanoscale surgery in a patient with pancreatic cancer

下载: 全尺寸图片幻灯片

图 5 评估胰腺癌患者纳米刀术后发生心肌损伤的ROC曲线

Figure 5. To evaluate the ROC curve of myocardial injury after nanoscale surgery in patients with pancreatic cancer

下载: 全尺寸图片幻灯片

表 1 两组患者临床资料进行比较

Table 1. the clinical data of the two groups were compared

指标	心肌损伤组(n=51)	非心肌损伤组(n=41)	统计值	P值
性别[例(%)]			χ²=0.601	0.438
女	27(52.9)	27(65.9)
男	24(47.1)	14(34.1)
年龄[例(%)]			χ²=0.344	0.558
＜65岁	22(43.1)	19(46.3)
≥65岁	29(56.9)	22(53.7)
BMI	22.7(21.2~24.5)	22.0(19.6~23.8)	Z=-1.603	0.109
肿瘤直径[例(%)]			χ²=3.426	0.064
＞4 cm	32(62.7)	15(36.6)
≤4 cm	19(37.3)	26(63.4)
糖尿病[例(%)]			χ²=0.091	0.763
无	23(45.1)	19(46.3)
有	28(54.9)	22(53.7)
高血压[例(%)]			χ²=12.124	＜0.001
无	26(51.0)	35(85.4)
有	25(49.0)	6(14.6)
慢性肾脏病[例(%)]			χ²=12.829	＜0.001
无	20(39.2)	27(65.9)
有	31(60.8)	14(34.1)
吸烟[例(%)]			χ²=0.015	0.903
否	42(82.4)	33(80.5)
是	9(17.6)	8(19.5)
酗酒[例(%)]			χ²=0.030	0.862
否	32(62.7)	25(61.0)
是	19(37.3)	16(39.0)
消融时间[例(%)]			χ²=7.410	0.006
≤1 h	18(35.3)	33(80.5)
＞1 h	33(64.7)	8(19.5)
手术方式[例(%)]			χ²=0.780	0.677
IRE	11(21.6)	29(70.7)
IRE+吻合	31(60.8)	7(17.1)
经皮	9(17.6)	5(12.2)
探针数量[例(%)]			χ²=6.130	0.047
2个	11(21.6)	30(73.2)
3个	10(19.6)	5(12.2)
4个	30(58.8)	6(14.6)

下载: 导出CSV

表 2 纳米刀术后发生心肌损伤的单因素分析结果

Table 2. Univariate analysis of myocardial injury after NanoKnife surgery

变量	OR(95%CI)	P值
性别		0.213
女性
男性	1.71(0.73~4.00)
年龄		0.759
＜65岁
≥65岁	0.88(0.38~2.01)
糖尿病史		0.905
无
有	1.05(0.46~2.40)
吸烟		0.819
否
是	0.88(0.31~2.54)
酗酒		0.862
否
是	1.08(0.46~2.51)
肿瘤直径		0.014
≤4 cm
＞4 cm	2.92(1.25~6.84)
消融时间		＜0.001
≤1 h
＞1 h	7.56(2.89~19.80)
手术方式
IRE
IRE+吻合	11.68(3.99~34.19)	＜0.001
经皮	4.75(1.30~17.32)	0.018
探针数量
2个
3个	5.45(1.52~19.55)	0.001
4个	13.64(4.47~41.63)	＜0.001
高血压病史		0.001
无
有	5.61(2.01~15.64)
慢性肾脏病史		0.012
无
有	2.99(1.27~7.04)

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