质子泵抑制剂在慢加急性肝衰竭治疗中的应用
DOI: 10.3969/j.issn.1001-5256.2022.12.035
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摘要: 质子泵抑制剂(PPI)是临床常用药物,目前在慢加急性肝衰竭人群中广泛应用。然而这一用药现状未得到美国胃肠病学会最新慢加急性肝衰竭临床指南推荐支持。笔者结合国内外指南或共识,综合最新研究进展,以评述PPI在慢加急性肝衰竭人群中的使用指征、可能获益及潜在风险,以期为临床慢加急性肝衰竭人群规范使用PPI提供参考。Abstract: Proton pump inhibitors (PPIs) are commonly used in clinical practice and are currently widely used in people with acute-on-chronic liver failure (ACLF). However, such medication is still not supported by the recommendations in the latest version of Clinical guidelines for acute-on-chronic liver failure issued by American College of Gastroenterology. With reference to the guidelines or consensus statements in China and globally and the latest research advances, this article elaborates on the indications, possible benefits, and potential risks of PPIs used in people with ACLF, in order to provide a reference for the standardized use of PPIs in the population with ACLF in clinical practice.
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Key words:
- Liver Failure /
- Proton Pump Inhibitors /
- Therapeutic Uses
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表 1 国内外肝衰竭指南对PPI应用的推荐意见
Table 1. Recommendations for PPI indications in domestic and international liver failure guidelines
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