胰腺癌与糖尿病的关系

南昇辰; 石乔; 陈辰; 王卫星

doi:10.3969/j.issn.1001-5256.2022.12.039

胰腺癌与糖尿病的关系

DOI: 10.3969/j.issn.1001-5256.2022.12.039

南昇辰^a,
石乔^a,
陈辰^b,
王卫星^a, , ,

a.
武汉大学人民医院胰腺外科, 武汉 430060
b.
武汉大学人民医院普外科, 武汉 430060

基金项目:

国家自然科学基金 (82170651);

国家自然科学基金 (81870442)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：南昇辰负责收集资料，整合资料，撰写论文；石乔负责拟定写作思路，指导文章撰写；陈辰负责修改文章；王卫星设计文章思路，审核文章并最后定稿。

详细信息

通信作者:
王卫星, sate.llite@163.com

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出版历程
- 收稿日期: 2020-07-30
- 录用日期: 2020-08-31
- 出版日期: 2022-12-20

Association between pancreatic cancer and diabetes

a.
Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China
b.
Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China

Research funding:

National Natural Science Foundation of China (82170651);

National Natural Science Foundation of China (81870442)

More Information

Corresponding author: WANG Weixing, sate.llite@163.com (ORCID: 0000-0002-3854-0083)

摘要

摘要: 胰腺癌是一类高度恶性的消化系统肿瘤，总体5年生存率不足10%。近年来，大量研究表明胰腺癌与糖尿病呈双向关系，糖尿病既是胰腺癌的高危因素之一，也是胰腺癌引起的一种副肿瘤现象。2型糖尿病患者的高血糖和高胰岛素血症是发生胰腺癌的危险因素；相反胰腺癌细胞通过自分泌或旁分泌引起胰岛β细胞功能受损，导致胰源性糖尿病的发生。本文对流行病学、发病机制及胰腺癌与糖尿病的双向关系作一综述，为临床提供参考。
- 胰腺肿瘤 /
- 糖尿病 /
- 病理过程
Abstract: Pancreatic cancer is a type of highly malignant digestive system tumor, with a 5-year overall survival rate of < 10%. In recent years, a large number of studies have shown that there is a two-way relationship between pancreatic cancer and diabetes; diabetes is not only one of the high-risk factors for pancreatic cancer, but also a paraneoplastic phenomenon caused by pancreatic cancer. Hyperglycemia and hyperinsulinemia in patients with type 2 diabetes are risk factors for pancreatic cancer, and on the contrary, pancreatic cancer cells cause the dysfunction of pancreatic β cells through autocrine or paracrine pathways and thus lead to the onset of pancreatic diabetes. This article reviews the epidemiology and pathogenesis of pancreatic cancer and the two-way relationship between pancreatic cancer and diabetes, so as to provide a reference for clinical practice.
- Pancreatic Neoplasms /
- Diabetes Mellitus /
- Pathologic Processes

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参考文献(51)

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