转化生长因子β在胰腺癌发生发展中的作用

张浩; 刘林勋; 赵占学; 潘洪帅; 侯晓凡; 霍峥

doi:10.3969/j.issn.1001-5256.2022.12.041

转化生长因子β在胰腺癌发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2022.12.041

张浩¹,
刘林勋^2, , ,,
赵占学²,
潘洪帅²,
侯晓凡¹,
霍峥¹

1.
青海大学研究生院, 西宁 810000
2.
青海省人民医院胆胰脾外科, 西宁 810000

基金项目:

青海省卫健委指导项目 (2020-wjzdx-28)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：张浩负责课题设计，资料分析，撰写论文；侯晓凡、霍峥负责查阅文献；刘林勋、赵占学、潘洪帅负责校正，修改论文，最后定稿。

详细信息

通信作者:
刘林勋, 147599835@qq.com

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出版历程
- 收稿日期: 2022-07-15
- 录用日期: 2022-09-13
- 出版日期: 2022-12-20

Role of transforming growth factor-β in the development and progression of pancreatic cancer

1.
Qinghai University Graduate School, Xining 810000, China
2.
Department of Biliary, Pancreatic, and Splenic Surgery, Qinghai Provincial People's Hospital, Xining 810000, China

Research funding:

Qinghai Provincial Health Commission Guidance Project (2020-wjzdx-28)

More Information

Corresponding author: LIU Linxun, 147599835@qq.com (ORCID: 0000-0003-1998-5746)

摘要

摘要: 胰腺导管腺癌恶性程度高，起病隐匿，病情进展快，在早期无明显的腹部表现及体征。多数患者就诊时已发展为中晚期，并常伴远处脏器转移，因此手术治疗、放化疗及药物靶向治疗效果通常不佳。近年来研究表明，转化生长因子β(TGFβ)与肿瘤的发生、发展密不可分，在肿瘤细胞的增殖、侵袭、迁移和血管的生成等进程中发挥关键性的调节作用。尽管TGFβ信号能够利用SMAD介导的细胞周期阻滞起到强大的肿瘤抑制作用，但是TGFβ信号也可以通过增强上皮-间质转化、纤维化和免疫逃逸来加速胰腺癌的发生。本文所述胰腺癌均特指为胰腺导管腺癌，旨在对TGFβ在其信号传导中的作用及其相关因子和免疫反应等方面关系的研究予以综述，为今后胰腺癌的靶向治疗提供理论依据。
- 胰腺肿瘤 /
- 转化生长因子β /
- 上皮-间质转化
Abstract: Pancreatic ductal adenocarcinoma has a high degree of malignancy, an insidious onset, and rapid progression, with no obvious abdominal manifestations and signs in the early stage. Most patients are already in the advanced stage and have distant organ metastasis at the time of diagnosis, and thus surgical treatment, chemoradiotherapy, and targeted drug therapy often have an unsatisfactory clinical effect. Recent studies have shown that transforming growth factor-β (TGF-β) is closely associated with the development and of tumors and plays a key role in the processes of tumor cell proliferation, invasion, migration, and angiogenesis. Although TGF-β signal can exert a powerful inhibitory effect on tumors through SMAD-mediated cell cycle arrest, TGF-β signal can also accelerate the development of pancreatic cancer by enhancing epithelial-mesenchymal transition, fibrosis, and immune escape. In this article, pancreatic cancer specifically refers to pancreatic ductal adenocarcinoma, and this article reviews the role of TGF-β in its signal transduction and the association of TGF-β with related factors and immune response, so as to provide a theoretical basis for targeted therapy for pancreatic cancer in the future.
- Pancreatic Neoplasms /
- Transforming Growth Factor beta /
- Epithelial-Mesenchymal Transition

HTML全文

图 1 胰腺癌微环境中TGFβ信号通路

Figure 1. TGFβ signaling pathway in the pancreatic tumor microenvironment

下载: 全尺寸图片幻灯片

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