Numb基因及其可变剪接在胰腺癌中的研究进展

李鹏昊; 郑楷炼; 许熊飞; 金钢

doi:10.3969/j.issn.1001-5256.2022.12.042

Numb基因及其可变剪接在胰腺癌中的研究进展

DOI: 10.3969/j.issn.1001-5256.2022.12.042

海军军医大学长海医院肝胆胰脾外科, 上海 200433

基金项目:

上海市2020年度“科技创新行动计划”自然科学基金项目 (20ZR1457300)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：李鹏昊负责拟定写作思路，检索文献和论文撰写；许熊飞、金钢、郑楷炼负责课题设计；郑楷炼负责指导、修改论文并最终定稿。

详细信息

通信作者:
郑楷炼, zhengkl828@126.com

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出版历程
- 收稿日期: 2022-06-01
- 录用日期: 2022-07-22
- 出版日期: 2022-12-20

Numb and its alternative splicing in pancreatic cancer

Department of Hepatobiliary Pancreatic and Splenic Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, China

Research funding:

Natural Science Fund project of Shanghai 2020 "Science and Technology Innovation Action Plan" (20ZR1457300)

More Information

Corresponding author: ZHENG Kailian, zhengkl828@126.com (ORCID: 0000-0002-7341-0639)

摘要

摘要: 胰腺癌是一种常见的消化道肿瘤，恶性程度高，预后极差。目前针对胰腺癌有多种治疗方案，但效果均不太理想。阐明胰腺癌发病机制仍是临床亟需解决的重要难题。可变剪接是真核生物基因表达调控的重要手段，同一基因的剪接异构体介导产生不同生物学表型，其异常可导致诸多疾病的产生。Numb，一种重要的细胞命运决定蛋白，其可变剪接近年来被发现与癌症的发生密切相关。在胰腺癌中Numb的选择性剪接可产生多种不同亚型的Numb蛋白，对癌症相关通路的活化以及肿瘤细胞生物学行为具有不同的调节作用，探索Numb的剪接异构体在胰腺癌中不同功能有利于解释胰腺癌发病机理和新疗法的开发。本文就Numb蛋白在胰腺癌中研究进展进行综述，着重探讨其剪接异构体功能特点以及不同亚型对胰腺癌各方面的调节作用。
- 胰腺肿瘤 /
- Numb /
- 剪接体
Abstract: Pancreatic cancer, a common digestive system tumor with high malignancy and a poor prognosis, has several treatment options. However, none of them are particularly effective because understanding the pathogenesis of pancreatic cancer remains a significant clinical challenge. Splicing isoforms mediate various biological phenotypes as an important means of regulating gene expression in eukaryotes, and their abnormalities can lead to a variety of diseases. Numb is an important cell fate determining protein whose alternative splicing has been linked to the development of various cancers. In pancreatic cancer, selective splicing of Numb can result in a variety of Numb protein subtypes, each with a different regulatory effect on the activation of various cancer-related signal pathways and tumor cell biology. This paper reviews the recent progress of Numb protein research in pancreatic cancer, with a focus on the regulatory role of its different isoforms in pathogenesis.
- Pancreatic Neoplasms /
- Numb /
- Spliceosomes

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参考文献(43)

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