胆汁酸受体TGR5介导的糖脂代谢在非酒精性脂肪性肝病中的作用

荀小霞; 周铖; 赵文霞

doi:10.3969/j.issn.1001-5256.2023.01.025

胆汁酸受体TGR5介导的糖脂代谢在非酒精性脂肪性肝病中的作用

DOI: 10.3969/j.issn.1001-5256.2023.01.025

荀小霞^1,,
周铖¹,
赵文霞^2, ,

1.
河南中医药大学第一临床医学院，郑州 450000
2.
河南中医药大学第一附属医院脾胃肝胆科，郑州 450000

基金项目:

国家自然科学基金面上项目 (81473651);

河南省中医药科学研究专项课题 (2018JDZX005);

河南省中医药科学研究专项课题 (2019JDZX2051);

河南省科技攻关计划项目 (202102310495);

河南省特色骨干学科中医学学科建设项目 (STG-ZYXKY-2020024)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：荀小霞负责撰写论文；周铖负责修改论文；赵文霞负责指导撰写文章、修改论文并最后定稿。

详细信息

通信作者:
赵文霞, zhao-wenxia@163.com (ORCID: 0000-0001-9070-4703)

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出版历程
- 收稿日期: 2022-05-15
- 录用日期: 2022-06-30
- 出版日期: 2023-01-20

Role of glucose and lipid metabolism mediated by the bile acid receptor Takeda G protein-coupled receptor 5 in nonalcoholic fatty liver disease

1.
The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450000, China
2.
Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China

Research funding:

National Natural Science Foundation of China (81473651);

Traditional Chinese Medicine Science Research Project of Henan Province (2018JDZX005);

Traditional Chinese Medicine Science Research Project of Henan Province (2019JDZX2051);

Key Science and Technology Project of Henan Province (202102310495);

TCM Discipline Construction Project of Characteristic Backbone Disciplines of Henan Province (STG-ZYXKY-2020024)

More Information

Corresponding author: ZHAO Wenxia, zhao-wenxia@163.com (ORCID: 0000-0001-9070-4703)

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)逐渐成为影响人类肝脏健康的主要原因，其发生发展与代谢功能障碍相关，糖脂代谢紊乱是其中的关键环节。武田G蛋白偶联受体5(TGR5)是胆汁酸的主要受体之一，在体内广泛表达，其介导的糖脂代谢在人体发挥重要作用。本文总结了TGR5在糖脂代谢中的作用和机制，以及基于TGR5治疗NAFLD的研究成果，以期对基础和临床研究提供参考。
- 受体，G-蛋白偶联 /
- 碳水化合物代谢 /
- 脂类代谢 /
- 非酒精性脂肪性肝病
Abstract: Nonalcoholic fatty liver disease (NAFLD) has gradually become a prominent cause affecting human liver health, and the development and progression of NAFLD are associated with metabolic dysfunction, with glucose and lipid metabolism disorder as the key link in this process. Takeda G protein-coupled receptor 5 (TGR5) is one of the main receptors of bile acid and is extensively expressed in the body, and glucose and lipid metabolism mediated by TGR5 plays an important role in the human body. This article summarizes the role and mechanism of TGR5 in glucose and lipid metabolism and the research findings of the treatment of NAFLD based on TGR5, in order to provide a reference for basic and clinical research.
- Receptors, G-Protein-Coupled /
- Carbohydrate Metabolism /
- Lipid Metabolism /
- Non-alcoholic Fatty Liver Disease

HTML全文

图 1 TGR5调节肠道L细胞分泌GLP-1的机制

Figure 1. Mechanism of TGR5 regulating GLP-1 secretion by intestinal L cells

下载: 全尺寸图片幻灯片

图 2 TGR5调节胰腺β细胞分泌胰岛素的机制

Figure 2. Mechanism of TGR5 regulating insulin secretion by pancreatic β cells

下载: 全尺寸图片幻灯片

图 3 骨骼肌内TGR5参与调节血糖代谢的机制

Figure 3. Mechanism of TGR5 in skeletal muscle involved in regulating blood glucose metabolism

下载: 全尺寸图片幻灯片

图 4 脂肪组织内TGR5参与调节脂质调节的机制

Figure 4. Mechanism of TGR5 involved in lipid regulation in adipose tissue

下载: 全尺寸图片幻灯片

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