细胞器之间相互作用在非酒精性脂肪性肝病发生发展中的作用

刘天会

doi:10.3969/j.issn.1001-5256.2023.01.028

细胞器之间相互作用在非酒精性脂肪性肝病发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2023.01.028

刘天会^, ,

首都医科大学附属北京友谊医院肝病中心，北京 100050

基金项目:

国家自然科学基金面上项目 (82070618)

利益冲突声明：作者声明不存在利益冲突。

详细信息

通信作者:
刘天会, liu_tianhui@163.com (ORCID: 0000-0001-6789-3016)

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出版历程
- 收稿日期: 2022-07-30
- 录用日期: 2022-08-31
- 出版日期: 2023-01-20

Role of organelle interaction in the development and progression of nonalcoholic fatty liver disease

Tianhui LIU^{,
,}

Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Research funding:

National Natural Science Foundation of China (82070618)

More Information

Corresponding author: LIU Tianhui, liu_tianhui@163.com (ORCID: 0000-0001-6789-3016)

摘要

摘要: 细胞器除了具有各自特定的功能外，还可与其他细胞器相互作用完成重要的生理功能。细胞器之间相互作用的异常与疾病的发生发展密切相关。近年来，细胞器之间相互作用在非酒精性脂肪性肝病(NAFLD)发生发展中的作用受到关注，特别是线粒体、脂滴与其他细胞器之间的相互作用。
- 非酒精性脂肪性肝病 /
- 细胞器 /
- 线粒体 /
- 脂肪滴
Abstract: In addition to its own specific functions, an organelle can also interact with other organelles to complete important physiological functions. The disorders of organelle interactions are closely associated the development and progression of various diseases. In recent years, the role of organelle interactions has attracted more attention in the progression of nonalcoholic fatty liver disease, especially the interactions between mitochondria, lipid droplets, and other organelles.
- Non-alcoholic Fatty Liver Disease /
- Organelles /
- Mitochondria /
- Lipid Droplets

HTML全文

图 1 线粒体与其他细胞器之间的相互作用

注：FFA，游离脂肪酸；IP3R，三磷酸肌醇受体；VDAC，电压依赖性阴离子选择性通道蛋白；GRP75，葡萄糖调节蛋白75；IFN2，肌动蛋白成核因子2；Spire1C，与甲酸结合的肌动蛋白成核蛋白1C；Mfn2，线粒体融合蛋白2；Plin1，脂滴包被蛋白1；Plin5，脂滴包被蛋白5；ECI2，烯酰辅酶A异构酶2；TOM20，线粒体外膜转位酶20；RAB7，Ras相关GTP结合蛋白7。图中使用的线粒体及高尔基体模式图来自BioRender网站。

Figure 1. Interactions between mitochondria and other organelles

下载: 全尺寸图片幻灯片

图 2 脂滴与其他细胞器之间的相互作用

注：UBXD8，泛素调节X结构域蛋白8；TGN，高尔基体反面囊膜；VPS13B，液泡蛋白分选相关蛋白13B；DGAT2，二酰甘油酰基转移酶2；CCTα，磷酸胆碱胞苷酰转移酶α；ATGL，脂肪甘油三酯脂肪酶。图中使用的细胞核及高尔基体模式图来自BioRender网站。

Figure 2. Interactions between lipid droplets and other organelles

下载: 全尺寸图片幻灯片

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