邻苯二甲酸酯对胆汁淤积性肝病影响的研究进展

张佳怡; 王建青

doi:10.3969/j.issn.1001-5256.2023.01.035

邻苯二甲酸酯对胆汁淤积性肝病影响的研究进展

DOI: 10.3969/j.issn.1001-5256.2023.01.035

张佳怡^{1, 2},
王建青^{1, 2, , ,}

1.
安徽医科大学第四附属医院药学部，合肥 230012
2.
安徽医科大学药学院，合肥 230022

基金项目:

国家自然科学基金 (82073566);

安徽省高校优秀青年人才支持计划资助项目 (gxyq2019014);

临床药学与药理学共建项目 (2020)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：张佳怡负责查阅文章，撰写论文; 王建青负责修改文章并最后定稿。

详细信息

通信作者:
王建青，jianqingwang81@126.com (ORCID: 0000-0002-7935-9520)

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出版历程
- 收稿日期: 2022-05-02
- 录用日期: 2022-07-25
- 出版日期: 2023-01-20

Research advances in the impact of phthalates on cholestatic liver disease

Jiayi ZHANG^{1, 2},
Jianqing WANG^{1, 2
, ,
,}

1.
Department of Pharmacy, The Fourth Affiliated Hospital of Anhui Medical University, Hefei 230012, China
2.
School of Pharmacy, Anhui Medical University, Hefei 230022, China

Research funding:

National Natural Science Foundation of China (82073566);

the Program of Excellent Young Talents in Universities of Anhui Province (gxyq2019014);

Co-sponsored by Clinical Pharmacy and Pharmacology (2020)

More Information

Corresponding author: WANG Jianqing, jianqingwang81@126.com (ORCID: 0000-0002-7935-9520)

摘要

摘要: 胆汁淤积性肝病是由于胆汁生成、排泄及代谢障碍，造成胆汁在肝脏沉积所致的一类常见肝胆疾病。目前胆汁淤积性肝病的致病因素尚未充分阐明，但有研究者认为环境因素可能在其中发挥重要作用。环境污染物邻苯二甲酸酯已被证实可干扰人类内分泌系统，对人体具有潜在毒性，危及肝肾功能，且可能增加肝内胆汁淤积的发生风险。基于此，本研究对邻苯二甲酸酯与胆汁淤积性肝病的关系进行综述，分别从临床研究、动物实验研究和体外实验研究及潜在机制进行总结，为胆汁淤积性肝病的预防以及临床治疗提供思路和参考。
- 胆汁淤积 /
- 胆酸 /
- 邻苯二甲酸酯
Abstract: Cholestatic liver disease is a common hepatobiliary disease caused by bile deposition in the liver due to the disorders of bile production, excretion, and metabolism. At present, the pathogenic factors for cholestatic liver disease have not been fully elucidated, but some researchers believe that environmental factors may play an important role in it. As environmental pollutants, phthalic acid esters (PAE) have been confirmed to interfere with human endocrine system, exert a potential toxic effect on the human body, endanger liver and kidney function, and increase the risk of intrahepatic cholestasis. On this basis, this article reviews the association between PAE and cholestatic liver disease and summarizes related clinical studies, animal experimental studies, in vitro experimental studies, and potential mechanisms, so as to provide ideas and references for the prevention and clinical treatment of cholestatic liver disease.
- Cholestasis /
- Cholic Acid /
- Phthalic Acid Esters

HTML全文

图 1 胆汁酸转运示意图

注：BA，胆汁酸；FXR，法尼醇受体；SHP，小异二聚体伴侣；CYP7A1，胆固醇7α－羟化酶；BSEP，胆盐输出泵；MRP2，胆盐输出泵；IBAT，回肠胆汁酸转运体；FGF19，成纤维细胞生长因子19；OATP，有机阴离子转运肽；NTCP，Na⁺-牛磺酸共转运多肽。

Figure 1. Bile acid transport

下载: 全尺寸图片幻灯片

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