选择性免疫球蛋白IgA缺乏症合并肺炎克雷伯菌肝脓肿1例报告

丁蕊; 刘丽改; 范颖; 王艳斌; 谢雯

doi:10.3969/j.issn.1001-5256.2023.02.022

选择性免疫球蛋白IgA缺乏症合并肺炎克雷伯菌肝脓肿1例报告

DOI: 10.3969/j.issn.1001-5256.2023.02.022

首都医科大学附属北京地坛医院肝病一科，北京 100015

基金项目:

北京市科委科技计划重大项目 (D171100003117005);

北京市医院管理中心消化内科学科协同发展中心消化专项重点项 (XXZ0402);

北京市医院管理中心重点医学专业发展计划 (ZYLX201808);

首都卫生发展科研专项 (CFH2022-2-2174)

伦理学声明：本例报告已获得患者知情同意。

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：丁蕊、谢雯负责病例资料分析，撰写论文；刘丽改、范颖、王艳斌参与收集数据，修改论文。

详细信息

通信作者:
谢雯，xiewen6218@163.com (ORCID: 0000-0002-7314-8175)

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出版历程
- 收稿日期: 2022-06-25
- 录用日期: 2022-07-15
- 出版日期: 2023-02-20

Klebsiella pneumoniae liver abscess in a patient with selective IgA deficiency

Center of Liver Disease, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China

Research funding:

Beijing Municipal Science and Technology Commission (D171100003117005);

Digestive Medical Coordinated Development Center of Beijing Municipal Administration (XXZ0402);

Beijing Hospitals Authority of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201808);

Capital's Funds for Health Improvement and Research (CFH2022-2-2174)

More Information

Corresponding author: XIE Wen, xiewen6218@163.com (ORCID: 0000-0002-7314-8175)

摘要

- IgA缺乏 /
- 肝脓肿 /
- 肺炎克雷伯菌
- IgA Deficiency /
- Liver Abscess /
- Klebsiella Pneumoniae

HTML全文

图 1 肝脏MRI

注：a，2020年8月14日检查；b，2021年10月18日检查。

Figure 1. MRI of the liver

下载: 全尺寸图片幻灯片

参考文献(30)

[1]	VO NGOC DT, KRIST L, van OVERVELD FJ, et al. The long and winding road to IgA deficiency: causes and consequences[J]. Expert Rev Clin Immunol, 2017, 13(4): 371-382. DOI: 10.1080/1744666X.2017.1248410.
[2]	BONILLA FA, KHAN DA, BALLAS ZK, et al. Practice parameter for the diagnosis and management of primary immunodeficiency[J]. J Allergy Clin Immunol, 2015, 136(5): 1186-1205. e1-78. DOI: 10.1016/j.jaci.2015.04.049.
[3]	LUDVIGSSON JF, NEOVIUS M, HAMMARSTRÖ ML. Risk of infections among 2100 individuals with IgA deficiency: a nationwide cohort study[J]. J Clin Immunol, 2016, 36(2): 134-140. DOI: 10.1007/s10875-015-0230-9.
[4]	MOHSEN AH, GREEN ST, READ RC, et al. Liver abscess in adults: ten years experience in a UK centre[J]. QJM, 2002, 95(12): 797-802. DOI: 10.1093/qjmed/95.12.797.
[5]	CHEN YC, LIN CH, CHANG SN, et al. Epidemiology and clinical outcome of pyogenic liver abscess: an analysis from the National Health Insurance Research Database of Taiwan, 2000-2011[J]. J Microbiol Immunol Infect, 2016, 49(5): 646-653. DOI: 10.1016/j.jmii.2014.08.028.
[6]	YIN D, JI C, ZHANG S, et al. Clinical characteristics and management of 1572 patients with pyogenic liver abscess: A 12-year retrospective study[J]. Liver Int, 2021, 41(4): 810-818. DOI: 10.1111/liv.14760.
[7]	HAO JH, YAO N, BI MY, et al. Clinical features of culture-negative liver abscess[J]. J Clin Hepatol, 2021, 37(1): 110-114. DOI: 10.3969/j.issn.1001-5256.2021.01.022. 郝建宏, 姚娜, 毕铭辕, 等. 病原学阴性肝脓肿的临床特征分析[J]. 临床肝胆病杂志, 2021, 37(1): 110-114. DOI: 10.3969/j.issn.1001-5256.2021.01.022.
[8]	DING R, WANG Q, LIU LG, et al. Predictive value of human immunodeficiency virus infection on prognosis pyogenic of liver abscess[J]. Chin Hepatol, 2021, 26(9): 1019-1023, 1056. DOI: 10.3969/j.issn.1008-1704.2021.09.020. 丁蕊, 王琦, 刘丽改, 等. 人类免疫缺陷病毒感染对肝脓肿预后的预测价值分析[J]. 肝脏, 2021, 26(9): 1019-1023, 1056. DOI: 10.3969/j.issn.1008-1704.2021.09.020.
[9]	Chinese Society of Surgery of Chinese Medical Association, Infectious Diseases Society for Evidence-based and Translational Medicine of Chinese Research Hospital Association, Editorial Board of Chinese Journal of Surgery. Expert consensus on multidisciplinary management of intra-abdominal infections[J]. Chin J Surg, 2021, 59(3): 161-178. DOI: 10.3760/cma.j.cn112139-20201223-00874. 中华医学会外科学分会, 中国研究型医院学会感染性疾病循证与转化专业委员会, 中华外科杂志编辑部. 外科常见腹腔感染多学科诊治专家共识[J]. 中华外科杂志, 2021, 59(3): 161-178. DOI: 10.3760/cma.j.cn112139-20201223-00874.
[10]	CHEN YW, CHEN YS, LEE SS, et al. A pilot study of oral fleroxacin once daily compared with conventional therapy in patients with pyogenic liver abscess[J]. J Microbiol Immunol Infect, 2002, 35(3): 179-183.
[11]	BASSETTI M, RIGHI E, CARNELUTTI A, et al. Multidrug-resistant Klebsiella pneumoniae: challenges for treatment, prevention and infection control[J]. Expert Rev Anti Infect Ther, 2018, 16(10): 749-761. DOI: 10.1080/14787210.2018.1522249.
[12]	DAIKOS GL, TSAOUSI S, TZOUVELEKIS LS, et al. Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems[J]. Antimicrob Agents Chemother, 2014, 58(4): 2322-2328. DOI: 10.1128/AAC.02166-13.
[13]	TUMBARELLO M, VIALE P, VISCOLI C, et al. Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy[J]. Clin Infect Dis, 2012, 55(7): 943-950. DOI: 10.1093/cid/cis588.
[14]	JAYOL A, NORDMANN P, POIREL L, et al. Ceftazidime/avibactam alone or in combination with aztreonam against colistin-resistant and carbapenemase-producing Klebsiella pneumoniae[J]. J Antimicrob Chemother, 2018, 73(2): 542-544. DOI: 10.1093/jac/dkx393.
[15]	SMITH JR, RYBAK JM, CLAEYS KC. Imipenem-cilastatin-relebactam: a novel β-lactam-β-lactamase inhibitor combination for the treatment of multidrug-resistant gram-negative infections[J]. Pharmacotherapy, 2020, 40(4): 343-356. DOI: 10.1002/phar.2378.
[16]	CASTANHEIRA M, DAVIS AP, MENDES RE, et al. In vitro activity of plazomicin against gram-negative and gram-positive isolates collected from U.S. hospitals and comparative activities of aminoglycosides against carbapenem-resistant enterobacteriaceae and isolates carrying carbapenemase genes[J]. Antimicrob Agents Chemother, 2018, 62(8): e00313-18. DOI: 10.1128/AAC.00313-18.
[17]	HITES M. Minireview on novel anti-infectious treatment options and optimized drug regimens for sepsis[J]. Front Med (Lausanne), 2021, 8: 640740. DOI: 10.3389/fmed.2021.640740.
[18]	MARTIN RM, BACHMAN MA. Colonization, infection, and the accessory genome of Klebsiella pneumoniae[J]. Front Cell Infect Microbiol, 2018, 8: 4. DOI: 10.3389/fcimb.2018.00004.
[19]	SEREK P, LEWANDOWSKI Ł, DUDEK B, et al. Klebsiella pneumoniae enolase-like membrane protein interacts with human plasminogen[J]. Int J Med Microbiol, 2021, 311(6): 151518. DOI: 10.1016/j.ijmm.2021.151518.
[20]	ZHANG J, VAN OOSTROM D, LI J, et al. Innate mechanisms in selective IgA deficiency[J]. Front Immunol, 2021, 12: 649112. DOI: 10.3389/fimmu.2021.649112.
[21]	HUUS KE, PETERSEN C, FINLAY BB. Diversity and dynamism of IgA-microbiota interactions[J]. Nat Rev Immunol, 2021, 21(8): 514-525. DOI: 10.1038/s41577-021-00506-1.
[22]	NAGAISHI T, WATABE T, KOTAKE K, et al. Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum[J]. Gut, 2022, 71(3): 487-496. DOI: 10.1136/gutjnl-2020-322873.
[23]	HAMMARSTRÖM L, VORECHOVSKY I, WEBSTER D. Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID)[J]. Clin Exp Immunol, 2000, 120(2): 225-231. DOI: 10.1046/j.1365-2249.2000.01131.x.
[24]	YAZDANI R, AZIZI G, ABOLHASSANI H, et al. Selective IgA deficiency: epidemiology, pathogenesis, clinical phenotype, diagnosis, prognosis and management[J]. Scand J Immunol, 2017, 85(1): 3-12. DOI: 10.1111/sji.12499.
[25]	ODINEAL DD, GERSHWIN ME. The epidemiology and clinical manifestations of autoimmunity in selective IgA deficiency[J]. Clin Rev Allergy Immunol, 2020, 58(1): 107-133. DOI: 10.1007/s12016-019-08756-7.
[26]	LU P, LING B, WANG N, et al. Study on immunoglobulin A deficiency (IgAD) in Chinese Shanghai blood donors[J]. J Exp Hematol, 2016, 24(4): 1216-1220. DOI: 10.7534/j.issn. 1009-2137.2016.04.047. 陆萍, 凌冰, 王宁, 等. 中国上海汉族人群IgA缺乏症的研究[J]. 中国实验血液学杂志, 2016, 24(4): 1216-1220. DOI: 10.7534/j.issn.1009-2137.2016.04.047.
[27]	YANG C, JIE W, YANLONG Y, et al. Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers[J]. Immunogenetics, 2012, 64(10): 747-753. DOI: 10.1007/s00251-012-0636-y.
[28]	ABOLHASSANI H, AGHAMOHAMMADI A, HAMMARSTRÖM L. Monogenic mutations associated with IgA deficiency[J]. Expert Rev Clin Immunol, 2016, 12(12): 1321-1335. DOI: 10.1080/1744666X.2016.1198696.
[29]	MUKHERJEE D, PAL P, KUNDU R. Brucella causing liver abscess in a child with selective IgA deficiency[J]. Indian Pediatr, 2017, 54(7): 595-596. DOI: 10.1007/s13312-017-1076-4.
[30]	SOLHPOUR A, HAJIABDOLBAGHI M, JAFARI S, et al. Subphrenic abscess and recurring focal lesions due to tuberculosis in a patient with IgA deficiency[J]. J Infect, 2007, 54(1): e9-12. DOI: 10.1016/j.jinf.2006.03.019.