肝窦内皮细胞与肝纤维化的关系

戴伟明; 陆伦根; 蔡晓波

doi:10.3969/j.issn.1001-5256.2023.02.027

肝窦内皮细胞与肝纤维化的关系

DOI: 10.3969/j.issn.1001-5256.2023.02.027

上海交通大学附属第一人民医院消化科，上海 200080

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：戴伟明负责文章结构设计，撰写文章；陆伦根负责论文修改；蔡晓波负责拟定写作思路，修改文章。

详细信息

通信作者:
蔡晓波，caixiaobo1979@hotmail.com(ORCID: 0000-0002-7351-1368)

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出版历程
- 收稿日期: 2022-08-13
- 录用日期: 2022-10-09
- 出版日期: 2023-02-20

Association between liver sinusoidal endothelial cells and liver fibrosis

Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China

More Information

Corresponding author: CAI Xiaobo, caixiaobo1979@hotmail.com(ORCID: 0000-0002-7351-1368)

摘要

摘要: 生理情况下，肝窦内皮细胞(LSEC)对肝脏稳态的维持起重要作用。而在肝脏病理损伤条件下，LSEC可通过改变其自身结构即毛细血管化对损伤做出反应，并加重肝损伤。此外，LSEC与肝脏中其他细胞的相互作用对肝纤维化的发生发展也有一定作用，其中与肝纤维化的主要效应细胞——肝星状细胞的交互作用占主体地位。本文主要阐述慢性肝损伤时LSEC在肝纤维化发生发展中的作用。
- 肝硬化 /
- 肝窦内皮细胞 /
- 肝星状细胞
Abstract: Liver sinusoidal endothelial cells (LSECs) are crucial to the maintenance of hepatic homeostasis under physiologic conditions, while under the conditions of pathological liver damage, LSEC can respond to the damage by changing their structure through the process called capillarization, thereby aggravating liver damage. In addition, the interaction between LSEC and other cells in the liver plays a certain role in the development and progression of liver fibrosis, especially the interaction between LSEC and hepatic stellate cells, which are the primary effector cells of liver fibrosis. This article mainly elaborates on the role of LSEC in the development and progression of liver fibrosis during chronic liver injury.
- Liver Cirrhosis /
- Liver Sinusoidal Endothelial Cells /
- Hepatic Stellate Cells

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图 1 正常或毛细血管化肝窦内皮细胞对肝纤维化的影响

Figure 1. Effect of normal or capillarized liver sinusoidal endothelial cells on liver fibrosis

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