基于脂质代谢异常探讨“痰浊”理论在肝细胞癌微环境中的生物学内涵

杨芳明; 肖准; 陈晓琦; 张传雷; 陈欣菊; 马素平; 赵文霞

doi:10.3969/j.issn.1001-5256.2023.02.029

基于脂质代谢异常探讨“痰浊”理论在肝细胞癌微环境中的生物学内涵

DOI: 10.3969/j.issn.1001-5256.2023.02.029

杨芳明¹,
肖准¹,
陈晓琦¹,
张传雷¹,
陈欣菊¹,
马素平¹,
赵文霞^{1, 2, , ,}

1.
河南中医药大学第一附属医院脾胃肝胆病科，郑州 450000
2.
河南中医药大学，郑州 450000

基金项目:

国家科技重大专项课题 (SQ2018ZX100303);

国家自然科学基金 (82205021);

河南省特色骨干学科中医学第二批学科建设项目 (STG-ZYX01-202101);

河南省中医药科学研究专项课题 (2022JDZX018);

河南中医药大学第一附属医院博士科研启动基金 (2021BSJJ007)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：杨芳明负责论文思路设计与撰写；肖准修改论文与做图；陈晓琦、张传雷、陈欣菊、马素平负责思路修改；赵文霞指导文章撰写并最后定稿。

详细信息

通信作者:
赵文霞，zhao-wenxia@163.com (ORCID: 0000-0001-6666-9469)

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出版历程
- 收稿日期: 2022-06-21
- 录用日期: 2022-08-18
- 出版日期: 2023-02-20

Biological connotation of "phlegm-turbidity" theory in hepatocellular carcinoma microenvironment based on abnormal lipid metabolism

1.
Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
2.
Henan University of Chinese Medicine, Zhengzhou 450000, China

Research funding:

National Science and Technology Major Project (SQ2018ZX100303);

National Natural Science Foundation of China (82205021);

The Second Batch of Discipline Construction Projects of Traditional Chinese Medicine in Henan Province's Characteristic Backbone Discipline (STG-ZYX01-202101);

Henan Province Traditional Chinese Medicine Scientific Research Special Project (2022JDZX018);

The Doctoral Research Foundation of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine (2021BSJJ007)

More Information

Corresponding author: ZHAO Wenxia, zhao-wenxia@163.com (ORCID: 0000-0001-6666-9469)

摘要

摘要: 肝癌的防治目前仍缺乏有效策略，对其发病机制的深入认识有助于开发新的治疗手段。由于脂质代谢在肝癌发生发展中的异常改变，其变化过程与中医“痰浊”理论密切相关。本文将从肝细胞癌微环境中脂质代谢变化入手，探讨脂质代谢在肿瘤细胞和免疫细胞群的异常改变与“痰浊”理论的相关性，以及临床应用化痰相关治法所取得的疗效。由于中医“痰浊”理论的致病特性在肝癌发病和病机变化中具有重要作用，因此对其理论内涵的分析有助于病理机制的阐明，也为中医药发挥防治肝癌作用提供理论依据。
- 癌, 肝细胞 /
- 脂类代谢 /
- 痰浊 /
- 医学, 中国传统
Abstract: There is still a lack of effective strategies for the prevention and treatment of liver cancer, and a deep understanding of its pathogenesis may help to develop new treatment methods. Due to the abnormal changes of lipid metabolism in the development and progression of liver cancer, such process is closely associated with the "phlegm-turbidity" theory in traditional Chinese medicine (TCM). Starting from the changes of lipid metabolism in hepatocellular carcinoma microenvironment, this article discusses the association of the abnormal changes of lipid metabolism in tumor cells and immune cells with the "phlegm-turbidity" theory and the clinical efficacy of phlegm-eliminating therapies in clinical practice. Since the "phlegm-turbidity" theory in TCM plays an important role in the pathogenesis and pathological changes of liver cancer, the analysis of its theoretical connotation helps to clarify pathological mechanism, thereby providing a theoretical basis for the role of TCM in the prevention and treatment of liver cancer.
- Carcinoma, Hepatocellular /
- Lipid Metabolism /
- Phlegm Turbidity /
- Medicine, Chinese Traditional

HTML全文

图 1 HCC肿瘤细胞脂质代谢改变

注：a，NAFLD相关HCC肿瘤细胞脂质代谢；b，β-catenin激活的HCC肿瘤细胞脂质代谢。红色：增加；蓝色：减少。SCD，硬脂酰辅酶A去饱和酶；MUFA，单不饱和脂肪酸；ACS，酰基辅酶A合成酶；FASN，脂肪酸合酶；CACT，肉毒碱脂酰转移酶；TCA，三羧酸循环；ATP，腺嘌呤核苷三磷酸；ACL，ATP-柠檬酸裂解酶；ACC，乙酰辅酶A羧化酶；CoA，辅酶A；Acyl-CoA，酰基辅酶A；Acetyl-CoA，乙酰辅酶A；Malonyl-CoA，丙二酰辅酶A。

Figure 1. Changes of lipid metabolism in HCC tumor cells

下载: 全尺寸图片幻灯片

图 2 HCC肿瘤细胞及免疫细胞脂质代谢变化

Figure 2. Changes of lipid metabolism in HCC tumor cells and immune cells

下载: 全尺寸图片幻灯片

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