白色脂肪棕色化对非酒精性脂肪性肝病的影响

赵晨露; 周铖; 尚东方; 刘素彤; 石俊豪; 王晓杰; 赵文霞

doi:10.3969/j.issn.1001-5256.2023.04.025

白色脂肪棕色化对非酒精性脂肪性肝病的影响

DOI: 10.3969/j.issn.1001-5256.2023.04.025

1.
河南中医药大学第一临床医学院，郑州 450046
2.
河南中医药大学第一附属医院脾胃肝胆科，郑州 450000

基金项目:

国家自然科学基金面上项目 (81473651);

河南省特色骨干学科中医学学科建设项目 (STG-ZYXKY-2020024)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：赵晨露负责查阅文献和撰写文章；周铖、尚东方、刘素彤、石俊豪、王晓杰负责查阅收集文献；赵文霞负责拟定写作思路，指导文章修改与定稿。

详细信息

通信作者:
赵文霞, zhao-wenxia@163.com (ORCID: 0000-0001-6666-9469)

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- 被引次数: 0
出版历程
- 收稿日期: 2022-08-02
- 录用日期: 2022-09-29
- 出版日期: 2023-04-20

Influence of white fat browning on nonalcoholic fatty liver disease

1.
The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450046, China
2.
Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China

Research funding:

National Natural Science Foundation of China (81473651);

Subject Construction Project of Traditional Chinese Medicine in Henan Province (STG-ZYXKY-2020024)

More Information

Corresponding author: ZHAO Wenxia, zhao-wenxia@163.com (ORCID: 0000-0001-6666-9469)

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)是由于脂肪代谢功能异常而出现大量脂肪类物质在肝细胞中蓄积的慢性肝病。常规的抗炎降酶治疗效果不佳，恢复人体脂类物质的正常生物合成与代谢是NAFLD的治疗关键。棕色脂肪已被证明可通过增强机体胰岛素敏感性、调节脂质代谢而改善代谢相关性疾病，促进人体白色脂肪棕色化治疗NAFLD受到了医学界的广泛关注。本文重点综述了白色脂肪棕色化改善NAFLD的作用机制，总结了促进白色脂肪棕色化的肝因子，为NAFLD的临床治疗提供新思路。
- 非酒精性脂肪性肝病 /
- 脂肪组织, 白色 /
- 脂肪组织, 棕色 /
- 脂肪组织, 米色
Abstract: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease in which a large amount of fat accumulates in hepatocytes due to lipid metabolism disorders. Conventional anti-inflammatory and transaminase-lowering treatment regimens often have an unsatisfactory therapeutic effect, and restoring the normal biosynthesis and metabolism of lipids is the key to the treatment of NAFLD. Studies have shown that brown adipose tissue can improve metabolic diseases by enhancing insulin sensitivity and regulating lipid metabolism, and the treatment of NAFLD by promoting white fat browning has attracted wide attention in the medical field. This article reviews the mechanism of white fat browning in improving NAFLD and summarizes the hepatokines that can promote white fat browning, so as to provide new ideas for the clinical treatment of NAFLD.
- Non-alcoholic Fatty Liver Disease /
- Adipose Tissue, White /
- Adipose Tissue, Brown /
- Adipose Tissue, Beige

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