非编码RNA对肝细胞癌肿瘤微环境中免疫细胞的作用

杨超然; 李思柔; 刘源; 侯志远; 王元; 杨季红

doi:10.3969/j.issn.1001-5256.2023.04.033

非编码RNA对肝细胞癌肿瘤微环境中免疫细胞的作用

DOI: 10.3969/j.issn.1001-5256.2023.04.033

河北大学附属医院肝胆外科，河北保定 071000

基金项目:

河北省政府资助临床医学优秀人才培养项目 (361007)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：杨超然、李思柔负责课题设计，资料分析，撰写论文；刘源、侯志远、王元参与收集数据，修改论文；杨季红负责拟定写作思路，指导撰写文章并最后定稿。杨超然和李思柔对本文贡献等同，同为第一作者。

详细信息

通信作者:
杨季红，doctoryangjh@sina.com(ORCID: 0000-0001-8844-8640)

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出版历程
- 收稿日期: 2022-07-28
- 录用日期: 2022-09-09
- 出版日期: 2023-04-20

Role of non-coding RNA on immune cells in tumor microenvironment of hepatocellular carcinoma

Department of Hepatobiliary Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China

Research funding:

Hebei Provincial Government Funded Clinical Medicine Talent Training Program (361007)

More Information

Corresponding author: YANG Jihong, doctoryangjh@sina.com (ORCID: 0000-0001-8844-8640)

摘要

摘要: 肝细胞癌(HCC)是一种常见的肝脏恶性肿瘤，具有发病率高、进展快、预后差等特点。近年来发现，非编码RNA(ncRNA)在肿瘤微环境(TME)中参与肿瘤免疫的调节，进而影响HCC的生物学行为。本文简述了ncRNA对TME中免疫细胞的调控作用，并介绍了ncRNA在HCC诊断和治疗中的潜在价值，以期为HCC提供潜在的诊断和治疗策略。
- 癌，肝细胞 /
- RNA /
- 肿瘤微环境 /
- 免疫，细胞
Abstract: Hepatocellular carcinoma (HCC) is a common malignant tumor of the liver characterized by a high incidence rate, rapid progression, and poor prognosis. In recent years, it has been found that non-coding RNA (ncRNA) participates in the regulation of tumor immunity in tumor microenvironment (TME) and in turn affects the biological behavior of HCC. This article briefly describes the regulatory effect of ncRNA on immune cells in TME and introduces the potential value of ncRNA in the diagnosis and treatment of HCC, in order to provide potential diagnostic and treatment strategies for HCC.
- Carcinoma, Hepatocellular /
- RNA /
- Tumor Microenvironment /
- Immunity, Cellular

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表 1 异常表达的ncRNA对免疫细胞的调控和功能

Table 1. Modulation of immune cells by abnormal expression ncRNA and function of ncRNA

ncRNA名称	HCC中表达	可检测位置	免疫相关分子	机制	功能
lncRNA HOMER3-AS1^[6]	高表达	HCC细胞	巨噬细胞、CSF-1	HOMER3/Wnt/β-连环蛋白轴	促进HCC进展
miR-570^[12]	低表达	组织和外周血	CD⁺8 T淋巴细胞、IFNγ ⁺T淋巴细胞	-	抑制HCC增殖
miR-26b-5^[13]	低表达	HCC细胞	CD4⁺和CD8⁺ T淋巴细胞(TNFα、IFNγ、IL-6和IL-2)	-	增强抗肿瘤免疫反应
miR-23a^[14]	低表达	细胞和组织	Treg	p65/miR-23a/CCL22	促进肿瘤生长
miR-206^[16]	高表达	细胞	巨噬细胞M1极化	KLF4/CCL2/CCR2	抑制HCC发展
miR-148b^[17]	低表达	细胞和组织	CSF-1表达和巨噬细胞浸润	-	促进HCC生长和转移
miR-506^[20]	低表达	细胞	NK细胞	-	增强抗肿瘤免疫反应
miR-561-5p^[21]	高表达	细胞和组织	NK细胞	miR-561-5p/CX3CL1/NK细胞	促进肿瘤发生和转移
lncRNA FENDRR^[23]	低表达	细胞和组织	Treg	-	抑制肿瘤的免疫逃逸
lncRNA NEAT1^[24]	低表达	外周血单核细胞	CD8⁺ T淋巴细胞	-	增强HCC细胞溶解
lncNNT-AS1^[25]	高表达	组织	CD4⁺ T淋巴细胞	-	增强肿瘤免疫逃逸
lncRNA00662^[29]	高表达	细胞	巨噬细胞M2极化	Wnt/β-catenin	促进肿瘤生长和转移
lncRNA GAS5^[34]	低表达	细胞	NK细胞	miR-544/RUNX3	增强抗肿瘤免疫反应
circRNA hsa_circ_0110102^[36]	高表达	组织	巨噬细胞	-	促进HCC进展
cricRNA Hsa_circ_0074854^[38]	高表达	细胞和组织	巨噬细胞M2极化	-	抑制HCC迁移和侵袭
注：-，文献未提及。

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