药物性肝损伤发生机制、危险因素、监测以及再用药的研究进展

刘茹佳; 辛小娟

doi:10.3969/j.issn.1001-5256.2023.04.034

药物性肝损伤发生机制、危险因素、监测以及再用药的研究进展

DOI: 10.3969/j.issn.1001-5256.2023.04.034

刘茹佳,
辛小娟^, ,

重庆医科大学附属第一医院感染科，重庆 400016

基金项目:

重庆市科卫联合医学科研项目 (2019ZDXM004)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：刘茹佳负责收集、分析资料，撰写文章；辛小娟负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
辛小娟，1152592844@qq.com (ORCID: 0000-0002-5463-9702)

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出版历程
- 收稿日期: 2022-08-14
- 录用日期: 2022-09-26
- 出版日期: 2023-04-20

Research advances in pathogenesis, risk factors, monitoring, and retreatment of drug-induced liver injury

Rujia LIU,
Xiaojuan XIN^{,
,}

Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

Research funding:

Chongqing Science and Health Joint Medical Research Project (2019ZDXM004)

More Information

Corresponding author: XIN Xiaojuan, 1152592844@qq.com (ORCID: 0000-0002-5463-9702)

摘要

摘要: 随着大量新药的审批上市，药物性肝损伤(DILI)发病率逐年升高，并可能影响患者原发病治疗。DILI作为药物不良反应不可能被完全消灭，临床目标是通过预防和控制将其影响降至最低。本文综述了DILI的危险因素和DILI监测以及再用药的相关研究进展。研究表明，某些因素在特定条件下可增加DILI的发生风险。通过早期识别DILI的危险因素，合理监测，注意再用药的时机和方法，能够减少DILI的发生或进展，改善患者预后。
- 化学性与药物性肝损伤 /
- 危险因素 /
- 再治疗
Abstract: With the approval and launch of a large number of new drugs, the incidence rate of drug-induced liver injury (DILI) is increasing year by year, which may affect the treatment of primary diseases. As an adverse drug reaction, DILI cannot be completely eliminated, and the clinical goal is to minimize its influence through prevention and control. This article reviews the research advances in the risk factors for DILI, the monitoring of DILI, and retreatment. Studies have shown that the risk of DILI can be increased by certain factors under some circumstances. Early identification of risk factors, rational monitoring, and focus on the timing and method for retreatment can reduce the development or progression of DILI and thus improve the prognosis of patients.
- Chemical and Drug Induced Liver Injury /
- Risk Factors /
- Retreatment

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