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摘要: 细胞疗法是区别于传统药物的新兴疗法,其中免疫细胞和间充质干细胞是目前治疗肝脏疾病最有前景的两类细胞,其展现的治疗效果已经初见成效。本文对肝脏疾病领域相关的细胞疗法进展进行总结,分析不同细胞疗法的挑战和应对策略,并对细胞疗法在肝脏相关疾病中的应用前景进行展望。Abstract: Cell therapy is an emerging therapy different from traditional drug therapy, among which immune cells and mesenchymal stem cells are the two types of most promising cells in the treatment of liver diseases at present, and preliminary results have been achieved for their therapeutic effects. This article summarizes the advances in cell therapy in the field of liver diseases, analyzes the challenges and coping strategies of different cell therapies, and discusses the application prospects of cell therapy in liver-related diseases.
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Key words:
- Liver Diseases /
- Cell Therapy /
- Mesenchymal Stem Cells /
- Adoptive Cell Therapy
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[1] SANGRO B, SAROBE P, HERVÁS-STUBBS S, et al. Advances in immunotherapy for hepatocellular carcinoma[J]. Nat Rev Gastroenterol Hepatol, 2021, 18(8): 525-543. DOI: 10.1038/s41575-021-00438-0. [2] CREELAN BC, WANG C, TEER JK, et al. Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial[J]. Nat Med, 2021, 27(8): 1410-1418. DOI: 10.1038/s41591-021-01462-y. [3] HUANG H, NIE CP, LIU XF, et al. Phase Ⅰ study of adjuvant immunotherapy with autologous tumor-infiltrating lymphocytes in locally advanced cervical cancer[J]. J Clin Invest, 2022, 132(15): e157726. DOI: 10.1172/JCI157726. [4] KRISTENSEN NP, HEEKE C, TVINGSHOLM SA, et al. Neoantigen-reactive CD8+ T cells affect clinical outcome of adoptive cell therapy with tumor-infiltrating lymphocytes in melanoma[J]. J Clin Invest, 2022, 132(2): e150535. DOI: 10.1172/JCI150535. [5] JIANG SS, TANG Y, ZHANG YJ, et al. A phase Ⅰ clinical trial utilizing autologous tumor-infiltrating lymphocytes in patients with primary hepatocellular carcinoma[J]. Oncotarget, 2015, 6(38): 41339-41349. DOI: 10.18632/oncotarget.5463. [6] WOLF NK, KISSIOV DU, RAULET DH. Roles of natural killer cells in immunity to cancer, and applications to immunotherapy[J]. Nat Rev Immunol, 2023, 23(2): 90-105. DOI: 10.1038/s41577-022-00732-1. [7] HOOGSTAD-VAN EVERT J, BEKKERS R, OTTEVANGER N, et al. Intraperitoneal infusion of ex vivo-cultured allogeneic NK cells in recurrent ovarian carcinoma patients (a phase Ⅰ study)[J]. Medicine (Baltimore), 2019, 98(5): e14290. DOI: 10.1097/MD.0000000000014290. [8] BAE WK, LEE BC, KIM HJ, et al. A phase Ⅰ study of locoregional high-dose autologous natural killer cell therapy with hepatic arterial infusion chemotherapy in patients with locally advanced hepatocellular carcinoma[J]. Front Immunol, 2022, 13: 879452. DOI: 10.3389/fimmu.2022.879452. [9] CICHOCKI F, VAN DER STEGEN S, MILLER JS. Engineered and banked iPSCs for advanced NK- and T-cell immunotherapies[J]. Blood, 2023, 141(8): 846-855. DOI: 10.1182/blood.2022016205. [10] SHI M, LI YY, XU RN, et al. Mesenchymal stem cell therapy in decompensated liver cirrhosis: a long-term follow-up analysis of the randomized controlled clinical trial[J]. Hepatol Int, 2021, 15(6): 1431-1441. DOI: 10.1007/s12072-021-10199-2. [11] WANG L, LI J, LIU H, et al. Pilot study of umbilical cord-derived mesenchymal stem cell transfusion in patients with primary biliary cirrhosis[J]. J Gastroenterol Hepatol, 2013, 28 (Suppl 1): 85-92. DOI: 10.1111/jgh.12029. [12] SALAMA H, ZEKRI AR, MEDHAT E, et al. Peripheral vein infusion of autologous mesenchymal stem cells in Egyptian HCV-positive patients with end-stage liver disease[J]. Stem Cell Res Ther, 2014, 5(3): 70. DOI: 10.1186/scrt459. [13] ZHANG Y, ZHANG J, YI H, et al. A novel MSC-based immune induction strategy for ABO-incompatible liver transplantation: a phase Ⅰ/Ⅱ randomized, open-label, controlled trial[J]. Stem Cell Res Ther, 2021, 12(1): 244. DOI: 10.1186/s13287-021-02246-4.
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