间充质干细胞治疗终末期肝病的临床研究进展

冯宇; 陈俊峰; 林炳亮

doi:10.3969/j.issn.1001-5256.2023.05.003

间充质干细胞治疗终末期肝病的临床研究进展

DOI: 10.3969/j.issn.1001-5256.2023.05.003

中山大学附属第三医院感染性疾病科，广州 510630

基金项目:

国家自然科学基金 (82070612);

国家自然科学基金 (81901940);

国家科技重大专项 (2018ZX10302204);

国家科技重大专项 (2017ZX10203201003);

广东省自然科学基金 (2021A1515010306);

广州市科技计划项目-重点研发计划 (2023B03J0154)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：林炳亮提出研究选题，设计研究方案；冯宇负责调研整理文献、撰写论文；陈俊峰、林炳亮提供指导性支持及修订、终审论文。

详细信息

通信作者:
林炳亮, linbingl@mail.sysu.edu.cn (ORCID: 0000-0003-4069-6287)

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出版历程
- 收稿日期: 2023-03-13
- 录用日期: 2023-04-13
- 出版日期: 2023-05-20

Clinical research advances in mesenchymal stem cells for the treatment of end-stage liver disease

Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China

Research funding:

National Natural Science Foundation of China (82070612);

National Natural Science Foundation of China (81901940);

National Science and Technology Major Project of China (2018ZX10302204);

National Science and Technology Major Project of China (2017ZX10203201003);

Natural Science Foundation of Guangdong Province (2021A1515010306);

Guangzhou Science and Technology Project-Key R & D Plan (2023B03J0154)

More Information

Corresponding author: LIN Bingliang, linbingl@mail.sysu.edu.cn. (ORCID: 0000-0003-4069-6287)

摘要

摘要: 终末期肝病(ESLD)包括失代偿期肝硬化和肝衰竭，其病情凶险，预后不佳。肝移植是唯一可以治愈ESLD的方法，但因肝源短缺、免疫排斥和费用昂贵等问题，其在临床中的应用受到很大限制。间充质干细胞(MSC)可分化为肝细胞样细胞，并可通过旁分泌调节机体免疫功能，改善肝纤维化，在治疗ESLD领域具有极广的应用前景。很多临床研究已经证明输注MSC治疗ESLD在短期内是安全有效的，其长期应用的安全性和有效性也有一定的临床证据支持。MSC分泌的外泌体没有完整的细胞结构，可通过多种机制促进肝细胞再生，其临床应用价值日益受到重视，但与之相关的临床研究仍寥寥可数。干细胞治疗ESLD的核心机制、制备干细胞的标准化流程等是当下亟待解决的问题。
- 终末期肝病 /
- 干细胞 /
- 间质干细胞 /
- 治疗学
Abstract: End-stage liver disease (ESLD) includes decompensated liver cirrhosis and liver failure, which usually have dangerous conditions and a poor prognosis. Liver transplantation is the only effective therapy for ESLD, but its clinical application is limited due to shortage of liver donors, immunological rejection, and expensive costs. Mesenchymal stem cells (MSCs) can differentiate into hepatocyte-like cells and alleviate liver fibrosis by regulating immune function through paracrine, and therefore, MSCs have a wide application prospect in the field of ESLD treatment. A number of clinical studies have shown that MSC infusion is safe and effective in the treatment of ESLD during a short period of time, and there is also certain clinical evidence for its long-term safety and efficacy. MSC-derived exosomes (MSC-Exo) do not have a complete cellular structure and can promote hepatocyte regeneration through a variety of mechanisms, and their clinical value has attracted more and more attention, but there are few studies on this issue. Currently, the core mechanism of MSC therapy for ESLD and the standardized process of MSC preparation are the problems needing to be solved urgently.
- End Stage Liver Disease /
- Stem Cells /
- Mesenchymal Stem Cells /
- Therapeutics

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参考文献(62)

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