巨噬细胞极化及其与邻近细胞串扰在肝细胞癌中的作用

苏会吉; 颜耿杰; 陈含笑; 班少群; 韦艾凌; 毛德文; 龙富立

doi:10.3969/j.issn.1001-5256.2023.05.032

巨噬细胞极化及其与邻近细胞串扰在肝细胞癌中的作用

DOI: 10.3969/j.issn.1001-5256.2023.05.032

苏会吉¹,
颜耿杰¹,
陈含笑¹,
班少群¹,
韦艾凌^{1, 2},
毛德文²,
龙富立^2, , ,

1.
广西中医药大学研究生院，南宁 530200
2.
广西中医药大学第一附属医院肝病二区，南宁 530023

基金项目:

国家自然科学基金 (81760844);

国家科技重大专项 (2018ZX10725505-001-011);

广西自然科学基金 (2020GXNSFAA297098);

广西中医药大学校级硕士研究生创新项目 (YCXJ2021058)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：苏会吉负责课题设计，资料分析，撰写论文；颜耿杰、陈含笑、班少群参与收集数据，修改论文；毛德文、韦艾凌、龙富立负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
龙富立，longfuli005@163.com (ORCID: 0000-0003-1196-2697)

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出版历程
- 收稿日期: 2022-08-31
- 录用日期: 2022-10-17
- 出版日期: 2023-05-20

Role of macrophage polarization and its crosstalk with neighboring cells in hepatocellular carcinoma

1.
Graduate School of Guangxi University of Chinese Medicine, Nanning 530200, China
2.
Second Department of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

Research funding:

National Natural Science Foundation of China (81760844);

National Science and Technology Major Project (2018ZX10725505-001-011);

Guangxi Science and Technology Project (2020GXNSFAA297098);

Guangxi University of Traditional Chinese Medicine Graduate Innovation Project (YCXJ2021058)

More Information

Corresponding author: LONG Fuli, longfuli005@163.com (ORCID: 0000-0003-1196-2697)

摘要

摘要: 炎症与癌症的发生密切相关。肿瘤相关巨噬细胞参与肿瘤相关炎症，促进肿瘤的生长和转移，在一定条件下又表现出细胞毒性和肿瘤杀伤活性，从而抑制癌症的发展。肿瘤相关巨噬细胞与邻近细胞之间的串扰与肝细胞癌的进展和治疗耐药性密切相关。本文综述了巨噬细胞在肝细胞癌中的作用及其细胞间的串扰联系，以期为肝细胞癌的临床诊疗提供新的治疗策略。
- 癌, 肝细胞 /
- 巨噬细胞 /
- 免疫疗法
Abstract: Inflammation is closely associated with the development of cancer. Tumor-associated macrophages (TAM) actively participate in tumor-related inflammation and promote tumor growth and metastasis, while under certain conditions, TAM also show cytotoxicity and tumor killing activity and thus inhibit the progression of cancer. Crosstalk between TAM and neighboring cells is closely associated with the progression of hepatocellular carcinoma (HCC) and drug resistance during treatment. This article summarizes the role of macrophages in HCC and the crosstalk between macrophages and other cells, so as to provide new strategies for the clinical diagnosis and treatment of HCC.
- Carcinoma, Hepatocellular /
- Macrophages /
- Immunotherapy

HTML全文

图 1 巨噬细胞极化及其特性

Figure 1. Macrophage polarization and its characteristics

下载: 全尺寸图片幻灯片

图 2 在肝癌TME中TAM与邻近细胞之间的串扰

Figure 2. Crosstalk between TAM and adjacent cells in HCC TME

下载: 全尺寸图片幻灯片

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