中医药防治慢性乙型肝炎肝纤维化的现状、挑战与思考

施梅姐; 萧焕明; 谢玉宝; 黎胜; 曾佛来; 池晓玲

doi:10.3969/j.issn.1001-5256.2023.06.004

中医药防治慢性乙型肝炎肝纤维化的现状、挑战与思考

DOI: 10.3969/j.issn.1001-5256.2023.06.004

广州中医药大学第二附属医院，广东省中医院肝病科，广州 510120

基金项目:

国家“十三五”重大传染病专项课题 (2018ZX10725506-003);

国家“十三五”重大传染病专项课题 (2018ZX10725505-004);

广东省基础与应用基础研究基金项目 (2022A1515110825);

广东省中医药局面上项目 (20211189);

广东省中医药局面上项目 (20225022);

广东省中医药局面上项目 (20231116);

广东省中医院院内专项 (YN10101903);

广东省中医院院内专项 (YN2016XP03);

广东省中医院院内专项 (YN2022DB04);

池晓玲国家中医药管理局名老中医药专家传承工作室项目 (Guozhong Pharmaceutical Human Education Letter [2022]No.75);

第五批全国中医临床优秀人才研修项目 (Guozhong Pharmaceutical Human Education Letter 2022]No.1)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：施梅姐撰写论文；萧焕明、谢玉宝、黎胜、曾佛来协助查阅文献; 池晓玲提供撰写思路，修改写作框架及审稿。

详细信息

通信作者:
池晓玲，chixiaolingqh@163.com (ORCID：0000-0003-3193-1943)

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出版历程
- 收稿日期: 2023-04-01
- 录用日期: 2023-05-01
- 出版日期: 2023-06-20

Role of traditional Chinese Medicine in prevention and treatment of chronic hepatitis B liver fibrosis: Current status, challenges, and thoughts

Department of Hepatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China

Research funding:

The Thirteenth Five Year Plan for Major and Special Programs of the National Science and Technology of China (2018ZX10725506-003);

The Thirteenth Five Year Plan for Major and Special Programs of the National Science and Technology of China (2018ZX10725505-004);

Guangdong Basic and Applied Basic Research Fund Project (2022A1515110825);

The General Project of Guangdong Provincial Bureau of Traditional Chinese Medicine (20211189);

The General Project of Guangdong Provincial Bureau of Traditional Chinese Medicine (20225022);

The General Project of Guangdong Provincial Bureau of Traditional Chinese Medicine (20231116);

The Science and Technology Research Project of Traditional Chinese Medicine of Guangdong Provincial Hospital of Chinese Medicine (YN10101903);

The Science and Technology Research Project of Traditional Chinese Medicine of Guangdong Provincial Hospital of Chinese Medicine (YN2016XP03);

The Science and Technology Research Project of Traditional Chinese Medicine of Guangdong Provincial Hospital of Chinese Medicine (YN2022DB04);

Chi Xiaoling of Project of Inheritance Workshop of Famous Old Chinese Medicine Experts of State Administration of Traditional Chinese Medicine (Guozhong Pharmaceutical Human Education Letter [2022]No.75);

The Fifth Batch of National Research and Training Programs for Clinical Talents of traditional Chinese Medicine (Guozhong Pharmaceutical Human Education Letter 2022]No.1)

More Information

Corresponding author: CHI Xiaoling, chixiaolingqh@163.com (ORCID: 0000-0003-3193-1943)

摘要

摘要: 近年来，中医药防治慢性乙型肝炎肝纤维化的相关研究取得了重大突破。在临床研究方面，产生了数个多中心的随机双盲对照研究，并以肝病理学变化为主要疗效评价指标，提高了中医药防治肝纤维化临床研究的证据级别。在基础研究方面，主要围绕影响肝星状细胞活化、凋亡与自噬、抑制肝脏炎症损伤、调节免疫、抑制肝窦毛细血管化等多个层面，深入研究了中医药抗肝纤维化的作用机制，突出了中医药“多成分、多靶点、多通路”的作用优势与研究难点。在《中医药振兴发展重大工程实施方案》的指引下，未来如何做更高质量的中医药抗肝纤维化的临床与基础研究，产出更高质量的行业成果，助力中医药抗肝纤维化走向世界是关键。
- 乙型肝炎, 慢性 /
- 肝纤维化 /
- 抗肝纤维化药(中药)
Abstract: In recent years, significant breakthroughs have been made in the research on the role of traditional Chinese medicine (TCM) in the prevention and treatment of chronic hepatitis B liver fibrosis. In terms of clinical research, several multicenter randomized double-blind controlled studies have been conducted with liver pathological changes as the main efficacy evaluation indicator, which have improved the level of evidence in clinical research on the TCM prevention and treatment of liver fibrosis. As for basic research, in-depth studies have been conducted on the mechanism of action of TCM in intervening against liver fibrosis at various levels, including the effect on HSC activation, apoptosis and autophagy, inhibition of liver inflammatory injury, immunoregulation, and inhibition of hepatic sinusoidal capillarization, thereby highlighting the advantages and research difficulties of TCM through "multiple components, targets, and pathways". Under the guidance of Implementation Plan for the Major Projects of Revitalizing and Developing TCM, it is crucial to conduct high-quality clinical and basic research on TCM in the treatment of liver fibrosis, produce high-quality industry achievements, and thus help TCM to be recognized around the world.
- Hepatitis B, Chronic /
- Hepatic Fibrosis /
- Anti-Hepato Fibrosis Agents (TCM)

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参考文献(37)

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