原发性胆汁性胆管炎合并结缔组织病及免疫性血小板减少症1例报告

刘庆夏; 张成港; 唐浩淋; 渠文静; 季慧范; 郭晓林

doi:10.3969/j.issn.1001-5256.2023.06.022

原发性胆汁性胆管炎合并结缔组织病及免疫性血小板减少症1例报告

DOI: 10.3969/j.issn.1001-5256.2023.06.022

吉林大学第一医院肝胆胰内科，长春 130021

伦理学声明：本例报告已获得患者及家属知情同意。

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：刘庆夏、郭晓林负责拟定写作思路；刘庆夏负责撰写文章；刘庆夏、张成港、唐浩淋、渠文静负责检索文献，分析资料；季慧范、郭晓林负责修改文章并最终定稿。

详细信息

通信作者:
郭晓林，guoxiaolin0324@126.com (ORCID：0000-0002-7814-5555)

计量
- 文章访问数: 417
- HTML全文浏览量: 84
- PDF下载量: 57
- 被引次数: 0
出版历程
- 收稿日期: 2022-10-20
- 录用日期: 2022-11-22
- 出版日期: 2023-06-20

A case of primary biliary cholangitis with connective tissue disease and immune thrombocytopenia

Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China

More Information

Corresponding author: GUO Xiaolin, guoxiaolin0324@126.com(ORCID: 0000-0002-7814-5555)

摘要

- 原发性胆汁性胆管炎 /
- 结缔组织病 /
- 血小板减少
- Primary Biliary Cholangitis /
- Connective Tissue Disease /
- Thrombocytopenia

HTML全文

图 1 血小板水平变化

Figure 1. Changes in levels of platelet

下载: 全尺寸图片幻灯片

图 2 肝酶水平变化

Figure 2. Changes in levels of liver enzymesl

下载: 全尺寸图片幻灯片

参考文献(11)

[1]	KAPLAN MM, GERSHWIN ME. Primary biliary cirrhosis[J]. N Engl J Med, 2005, 353(12): 1261-1273. DOI: 10.1056/NEJMra043898.
[2]	EFE C, TORGUTALP M, HENRIKSSON I, et al. Extrahepatic autoimmune diseases in primary biliary cholangitis: prevalence and significance for clinical presentation and disease outcome[J]. J Gastroenterol Hepatol, 2021, 36(4): 936-942. DOI: 10.1111/jgh.15214.
[3]	CHEN S, LI MQ, DUAN WJ, et al. Concomitant extrahepatic autoimmune diseases do not compromise the long-term outcomes of primary biliary cholangitis[J]. Hepatobiliary Pancreat Dis Int, 2022, 21(6): 577-582. DOI: 10.1016/j.hbpd.2022.05.009.
[4]	WATT FE, JAMES OF, JONES DE. Patterns of autoimmunity in primary biliary cirrhosis patients and their families: a population-based cohort study[J]. QJM, 2004, 97(7): 397-406. DOI: 10.1093/qjmed/hch078.
[5]	PANZER S, PENNER E, NELSON PJ, et al. Identification of the platelet glycoprotein IIb/IIIa complex as a target antigen in primary biliary cirrhosis-associated autoimmune thrombocytopenia. Evidence that platelet-reactive autoantibodies can also bind to the mitochondrial antigen M2[J]. J Autoimmun, 1990, 3(4): 473-483. DOI: 10.1016/s0896-8411(05)80014-9.
[6]	KUWANA M, KABURAKI J, PANDEY JP, et al. HLA class Ⅱ alleles in Japanese patients with immune thrombocytopenic purpura. Associations with anti-platelet glycoprotein autoantibodies and responses to splenectomy[J]. Tissue Antigens, 2000, 56(4): 337-343. DOI: 10.1034/j.1399-0039.2000.560405.x.
[7]	TANAKA A, LEUNG P, GERSHWIN ME. The genetics of primary biliary cholangitis[J]. Curr Opin Gastroenterol, 2019, 35(2): 93-98. DOI: 10.1097/MOG.0000000000000507.
[8]	LI Y, LIU X, WANG Y, et al. Novel HLA-DRB1 alleles contribute risk for disease susceptibility in primary biliary cholangitis[J]. Dig Liver Dis, 2022, 54(2): 228-236. DOI: 10.1016/j.dld.2021.04.010.
[9]	MA WY, DENG ZH. Current status of immunogenetic studies on primary biliary cholangitis[J]. J Clin Hepatol, 2020, 36(4): 932-935. DOI: 10.3969/j.issn.1001-5256.2020.04.050. 马伟煜, 邓志华. 原发性胆汁性胆管炎的免疫遗传研究现状[J]. 临床肝胆病杂志, 2020, 36(4): 932-935. DOI: 10.3969/j.issn.1001-5256.2020.04.050.
[10]	NEUNERT C, TERRELL DR, ARNOLD DM, et al. American Society of Hematology 2019 guidelines for immune thrombocytopenia[J]. Blood Adv. 2019. 3(23): 3829-3866. DOI: 10.1182/bloodadvances.2019000966.
[11]	Chinese Society of Hepatology, Chinese Medical Association. Guidelines on the diagnosis and management of primary biliary cholangitis (2021)[J]. J Clin Hepatol, 2022, 38(1): 35-41. DOI: 10.3760/cma.j.cn112138-20211112-00794.