肝硬化肾损伤的发病机制与诊治进展

刘清清; 杨婧; 胡绍山; 李苹菊; 金秋; 马红琳

doi:10.3969/j.issn.1001-5256.2023.06.032

肝硬化肾损伤的发病机制与诊治进展

DOI: 10.3969/j.issn.1001-5256.2023.06.032

昆明医科大学第二附属医院消化内科，昆明 650106

基金项目:

昆明医科大学第二附属医院院内临床项目 (ynllT2021012)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：刘清清负责文章设计并撰写论文；胡绍山、李苹菊、马红琳、金秋参与查阅并整理分析文献；杨婧负责指导撰写修改论文。

详细信息

通信作者:
杨婧，yangjing_dl@163.com (ORCID：0000-0002-3526-7552)

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出版历程
- 收稿日期: 2022-10-06
- 录用日期: 2022-11-07
- 出版日期: 2023-06-20

Advances in the pathogenesis, diagnosis, and treatment of renal injury in liver cirrhosis

Department of Gastroenterology, the Second Affiliated Hospital of Kunming Medical University, Kunming 650106, China

Research funding:

In Hospital Clinical Project of the Second Affiliated Hospital of Kunming Medical University (ynllT2021012)

More Information

Corresponding author: YANG Jing, yangjing_dl@163.com (ORCID: 0000-0002-3526-7552)

摘要

摘要: 肝硬化失代偿期患者常因严重的肝功能不全导致扩血管物质灭活减少、血流动力学紊乱、体内免疫系统紊乱、感染等因素引起肾功能的下降，若不及时干预则会由早期的肾前性损伤逐步发展至晚期的肾衰竭，患者存活率低、治疗难度大。随着肾损伤的分类和诊断标准逐渐明确，以及越来越多的肾损伤标志物得以发现，早期诊断及定位肾损伤的阶段对改善患者预后非常重要。本文分析了近年来肝硬化患者肾损伤的发病机制、诊断标准及治疗方面的新进展。以期为临床肝硬化肾损伤患者的诊治提供帮助。
- 肝硬化 /
- 肾损伤 /
- 诊断 /
- 治疗学
Abstract: Patients with decompensated cirrhosis often have a reduction in renal function due to severe hepatic insufficiency which results in reduced inactivation of vasodilators, hemodynamic disorders, immune disorders, and infections, and without timely intervention, patients may gradually develop from early prerenal injury to late renal failure. Patients tend to have a low survival rate and great difficulties in treatment. With the gradual clarification of the classification and diagnostic criteria for kidney injury and the discovery of an increasing number of markers for kidney injury, early diagnosis and localization of kidney injury are of great importance for improving the prognosis of patients. This article analyzes the new advances in the pathogenesis, diagnostic criteria, and treatment of renal injury in cirrhotic patients in recent years, so as to provide help for the clinical diagnosis and treatment of cirrhotic patients with renal injury.
- Liver Cirrhosis /
- Kidney Injury /
- Diagnosis /
- Therapeutics

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参考文献(41)

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