基于NK细胞的免疫治疗在肝癌中的研究进展

程世纪; 匡天瑞; 董可帅; 余佳

doi:10.3969/j.issn.1001-5256.2023.06.034

基于NK细胞的免疫治疗在肝癌中的研究进展

DOI: 10.3969/j.issn.1001-5256.2023.06.034

武汉大学人民医院肝胆外科，武汉 430060

基金项目:

国家自然科学基金 (82003063);

武汉大学学位与研究生教育改革研究项目 (1605-413200097)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：程世纪负责查找文献，撰写文章；匡天瑞、董可帅负责修改文章; 余佳负责指导撰写文章并最后定稿。

详细信息

通信作者:
余佳，hbpennhmp116@163.com (ORCID：0000-0002-2503-0025)

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出版历程
- 收稿日期: 2022-09-18
- 录用日期: 2022-11-10
- 出版日期: 2023-06-20

Research advances in natural killer cell-based immunotherapy in liver cancer

Department of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China

Research funding:

National Natural Science Foundation of China (82003063);

Research Project of Degree and Postgraduate Education Reform of Wuhan University (1605-413200097)

More Information

Corresponding author: YU Jia, hbpennhmp116@163.com (ORCID: 0000-0002-2503-0025)

摘要

摘要: 自然杀伤细胞(NK细胞)是人体重要的免疫细胞，也是肝内主要的淋巴细胞，被认为是抵御肿瘤的第一道防线，对肝癌发生发展有重大影响。NK细胞所具有的特性，使其成为免疫治疗的新选择，基于NK细胞的免疫疗法或将在肝癌治疗中取得成功。本文就NK细胞的生物学特征、其在肝癌发生发展中的作用及相关治疗中的研究进展进行综述。
- 肝肿瘤 /
- 杀伤细胞 /
- 天然 /
- 免疫疗法
Abstract: Natural killer (NK) cells are important immune cells in the human body and are also the main lymphocytes in the liver. They are considered the first defense mechanism against tumor and have a significant impact on the development and progression of liver cancer. The characteristics of NK cells help them become a new choice for immunotherapy, and NK cell-based immunotherapy may succeed in the treatment of liver cancer. This article reviews the biological characteristics of NK cells, their role in the development and progression of liver cancer, and the research advances in related treatment.
- Liver Neoplasms /
- Killer Cells /
- Natural /
- Immunotherapy

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参考文献(44)

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